Prostate Cell News Volume 8.30 | Aug 11 2017

TOP STORY

TMPRSS2–ERG Fusion Co-Opts Master Transcription Factors and Activates NOTCH Signaling in Primary Prostate Cancer

Using chromatin, genomic and expression data, scientists showed distinct cis-regulatory landscapes between TMPRSS2–ERG (T2E)-positive and non-T2E primary prostate tumors, which include clusters of regulatory elements. [Nat Genet] Abstract | Press Release | Video

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

DMAPT Inhibits NF-κB Activity and Increases Sensitivity of Prostate Cancer Cells to X-Rays In Vitro and in Tumor Xenografts In Vivo

Investigators showed that treatment of PC-3 and DU145 human prostate cancer cells with dimethylaminoparthenolide (DMAPT), a parthenolide derivative with increased bioavailability, inhibits constitutive and radiation-induced NF-κB binding activity and slows prostate cancer cell growth. [Free Radic Biol Med] Full Article | Graphical Abstract

Dioscin Induces Prostate Cancer Cell Apoptosis through Activation of Estrogen Receptor-β

The activity and mechanism of dioscin, a natural product, against prostate cancer were investigated. The results showed that dioscin markedly inhibited cell viability, colony formation, motility and induced apoptosis in PC3 cells. [Cell Death Dis] Full Article

The miR-183 Family Cluster Alters Zinc Homeostasis in Benign Prostate Cells, Organoids and Prostate Cancer Xenografts

Scientists studied the effect of overexpression of the entire 4.8 kb miR-183 family cluster, including the intergenic region which contains highly conserved genomic regions, in prostate cells. [Sci Rep] Full Article

Knockdown of HIF-1α by siRNA-Expressing Plasmid Delivered by Attenuated Salmonella Enhances the Antitumor Effects of Cisplatin on Prostate Cancer

The in vitro and in vivo effects of hypoxia-inducible factor-1 alpha (HIF-1α) siRNA treatment and/or cisplatin on prostate cancer cell proliferation, apoptosis, glycolysis, and production of reactive oxygen species were assessed by examining molecular markers specific to each process. [Sci Rep] Full Article

Reversion of Epithelial-Mesenchymal Transition by a Novel Agent DZ-50 via IGF Binding Protein-3 in Prostate Cancer Cells

The authors demonstrated that DZ-50 increased expression of the epithelial marker E-cadherin, and decreased the mesenchymal marker N-cadherin in human prostate cancer cells. In DU-145 cells, the effect of DZ-50 on EMT towards MET was inhibited by talin1 overexpression, a focal adhesion regulator promoting anoikis resistance and tumor invasion. [Oncotarget] Full Article

Leucine-Rich Repeat-Containing G Protein Coupled Receptor 4 (Lgr4) Is Necessary for Prostate Cancer Metastasis via Epithelial-Mesenchymal Transition

LGR4 expression was elevated in human prostate cancer cell lines with metastatic potential. Researchers generated a novel transgenic adenocarcinoma of the mouse prostate mouse model to investigate the role of Lgr4 in prostate cancer development and metastasis in vivo. [J Biol Chem] Abstract

ACSL3 Promotes Intratumoral Steroidogenesis in Prostate Cancer Cells

Researchers overexpressed long-chain acyl-coenzyme A synthetase 3 (ACSL3) in androgen-dependent LNCaP cells and examined the downstream effectors of ACSL3. They examined the role of ACSL3 in the androgen metabolism of prostate cancer. [Cancer Sci] Abstract

Total Glucosides of Paeony Inhibits Lipopolysaccharide-Induced Proliferation, Migration and Invasion in Androgen Insensitive Prostate Cancer Cells

The authors investigated whether total glucosides of paeony, the active constituents extracted from the root of Paeonia Lactiflora Pall, suppressed lipopolysaccharide-stimulated proliferation, migration and invasion in androgen insensitive prostate cancer cells. [PLoS One] Full Article

CLINICAL RESEARCH

Q-TWiST Analysis of Patients with Metastatic Castrate Naive Prostate Cancer Treated by Androgen Deprivation Therapy with or without Docetaxel in the Randomized Phase III GETUG-AFU 15 Trial

Scientists assessed the trade-offs between toxicity and survival using a Quality-adjusted Time Without Symptoms of disease and Toxicity of treatment (Q-TWiST) analysis. [Eur J Cancer] Abstract

Tissue Control of Androgen Action: The Ups and Downs of Androgen Receptor Expression

A clear understanding of the multiple transcription factors participating in regulation of the androgen receptor gene will likely aid in the development and application of hormone therapies to boast or curb receptor activity. [Mol Cell Endocrinol] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Cancer Research Institute and Israel Cancer Research Fund Announce Launch of The Immunotherapy Promise Initiative

The Cancer Research Institute and Israel Cancer Research Fund announced the establishment of The Immunotherapy Promise™ fund, a groundbreaking, collaborative campaign bringing together the leading funder of immunotherapy research internationally with North America’s largest nonprofit dedicated to supporting Israeli cancer research. [Cancer Research Institute] Press Release

Cancer Research UK and Biotecnol to Trial New Immuno-Oncology Treatment for Advanced Tumors

An experimental immuno-oncology treatment will move into early phase clinical trials for patients with advanced solid tumors, including lung cancers, under a collaboration agreement between Cancer Research UK and Biotecnol Limited. [Cancer Research UK] Press Release

Americans Are Becoming More Open to Human Genome Editing, Survey Finds, but Concerns Remain

Earlier surveys of Americans found a reluctance to support human genome editing, with many respondents expressing ethical and other concerns about such intentional tinkering. A new survey found that two-thirds of the 1600 respondents thought genome editing was generally “acceptable.” But that acceptance was qualified, and colored by religious beliefs and scientific knowledge. [ScienceInsider] Editorial

Thousands across India March in Support of Science

Thousands of scientists, university students and science enthusiasts gathered in dozens of Indian cities to march in support of science — lamenting their country’s low levels of funding for research, and complaining about government promotion of ‘unscientific ideas’. [Nature News] Editorial

NEW EACR-MRS: Seed and Soil: In Vivo Models of Metastasis
November 27-29, 2017
Berlin, Germany

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NEW Postdoctoral Research Fellow – Prostate Cancer (Edith Cowan University)

Postdoctoral Fellowship – Translational Cancer Disparities Research (Duke Cancer Institute)

Postdoctoral Research Associate – Prostate Cancer (University of South Carolina)

Postdoctoral Position – Prostate Cancer (Baylor College of Medicine)

Computational Biologist – Prostate Cancer (Cancer Research UK Manchester Institute)

Post-Doctoral Research Associate Position – Translational Cancer Immunology and Immunotherapy (Northwestern University)

Postdoctoral Scholar Position – Prostate Cancer (Case Western Reserve University)

Postdoctoral Position – Prostate Cancer (Cleveland Clinic)

Postdoctoral Position – Prostate Related Diseases (Baylor College of Medicine)

Postdoctoral Fellow – Functional Cancer Genomics (Institute of Oncology Research)

Assistant Member – Prostate Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Drug Discovery (The Vancouver Prostate Centre)

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