Prostate Cell News Volume 8.37 | Sep 29 2017

TOP STORY

Discovery of a Selective Catalytic p300/CBP Inhibitor That Targets Lineage-Specific Tumors

Scientists described A-485, a potent, selective and drug-like catalytic inhibitor of p300 and CREB-binding protein (CBP). A-485 inhibited the androgen receptor transcriptional program in both androgen-sensitive and castration-resistant prostate cancer and inhibited tumor growth in a castration-resistant xenograft model. [Nature] Abstract

(Ranked by impact factor of the journal)

Triptorelin Tethered Multifunctional PAMAM-Histidine-PEG Nanoconstructs Enable Specific Targeting and Efficient Gene Silencing in LHRH Overexpressing Cancer Cells

Investigators developed a multifunctional targeted nano-constructs, which can efficiently and precisely deliver siRNA, and silence the desired gene of interest in various LHRH overexpressing cancer cells. They reported the development of a triblock, PAMAM-Histidine-PEG dendritic nanoconstructs functionalized with Triptorelin or targeted siRNA delivery to LHRH overexpressing breast and prostate cancer cells. [ACS Appl Mater Interfaces] Abstract

Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development

Researchers developed a high-throughput peptide microarray assay to identify altered histone lysine (de)acetylation activity in prostate cancer (PCa). This microarray-based activity assay revealed up-regulated histone acetyltransferase activity against specific histone H3 sites in a castrate-resistant PCa cell line compared to its hormone-sensitive isogenic counterpart. [ACS Chem Biol] Abstract

Testosterone/Bicalutamide Antagonism at the Predicted Extracellular Androgen Binding Site of ZIP9

Using a cell line that lacks the classical androgen receptor scientists showed that ZIP9-mediated phosphorylation of Erk1/2, CREB, or ATF-1 and expression of claudin-5 and zonula occludens-1 by testosterone could be completely antagonized by bicalutamide, an anti-androgen of significant clinical impact. [Biochim Biophys Acta] Abstract

Myristoylation of Src Kinase Mediates Src Induced and High Fat Diet Accelerated Prostate Tumor Progression in Mice

Investigators demonstrated that increased Src kinase activity was associated with high fat diet accelerated progression of prostate tumors and that Src kinases mediated this pathological process. [J Biol Chem] Abstract | Full Article

Inefficient UGT-Conjugation of Adrenal 11β-Hydroxyandrostenedione Metabolites Highlights C11-Oxy C₁₉ Steroids as the Predominant Androgens in Prostate Cancer

The authors investigated the contribution of 11β-hydroxyandrostenedione (11OHA4) and 11β-hydroxytestosterone (11OHT) to the pool of active androgens in the prostate. Steroid profiles were determined in LNCaP, C4-2B and VCaP cell models, in prostate cancer tissue, and in plasma focussing on the inactivation, reactivation and glucuronidation of 11OHA4, 11OHT and their downstream products using ultra-performance convergence chromatography tandem mass spectrometry. [Mol Cell Endocrinol] Abstract

Anticarcinogenic Effect of Spices Due to Phenolic and Flavonoid Compounds—In Vitro Evaluation on Prostate Cells

Scientists showed the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines. The results of an MTT assay on extracts from eight spices revealed the strongest inhibitory effects were from black pepper and caraway seed extracts. [Molecules] Abstract | Full Article

Effects of Testosterone and 17β‑Estradiol on Angiotensin‑Induced Changes in Tyrosine Kinase Activity in the Androgen‑Independent Human Prostate Cancer Cell Line, DU145

The authors examined the influence of 17β‑estradiol and testosterone on AngII and Ang1‑7 action on protein tyrosine kinase (PTK) activity in androgen‑independent human prostate cancer cell line DU145. Cell cultures of human prostate cancer DU145 cells were used as a source of PTKs. [Int J Mol Med] Abstract

Down-Regulation of miR-605 Promotes the Proliferation and Invasion of Prostate Cancer Cells by Up-Regulating EN2

Researchers investigated the role of miR-605 and EN2 in prostate cancer (PCa). The expression of miR-605 and EN2 protein in PCa tissues and cells were determined by qRT-PCR and western blot, respectively. [Nutr Cancer] Abstract

Cell Plasticity in Epithelial Homeostasis and Tumorigenesis

The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumor initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and the epithelial–mesenchymal transition—two distinct, yet closely related, forms of plasticity with fundamental roles in homeostasis and cancer. [Nat Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

UC Davis Receives $8 Million to Expand Access to Stem Cell Clinical Trials

The California Institute for Regenerative Medicine awarded a nearly $8 million grant to University of California, Davis, stem cell researchers to launch a special clinical trials program in Sacramento to accelerate the therapeutic development and delivery of stem cell therapies in human patients. [University of California, Davis] Press Release

Charities Unite to Award $2.5M for Breast and Prostate Cancer Research

Leading Australian cancer researcher Professor Wayne Tilley has been presented with a $2.5 million Breast & Prostate Cancer Linkage Grant, thanks to a groundbreaking collaboration between the National Breast Cancer Foundation and the Movember Foundation. [The University of Adelaide] Press Release

Champions Oncology Announces $2 Million Award from the National Cancer Institute (NCI) to Develop and Evaluate Prostate Cancer PDX Models

Champions Oncology, Inc. announced the signing of a competitive contract through the government’s Small Business Innovation Research program. The contract is in response to Topic 355 – Cell and Animal-Based Models to Advance Cancer Ethnic Health Disparity Research. Champions’ direct-to-Phase II proposal, entitled “Metastatic Prostate Cancer Patient Derived Xenograft Modeling; A New Operating Paradigm”. [Champions Oncology, Inc.] Press Release

Researchers Caught in Growing Rift over Catalan Independence

Scientists in Catalonia are feeling the ripples of a severe crisis as the region’s bid for independence from Spain comes to a head. [ScienceInsider] Editorial

How the Latest US Travel Ban Could Affect Science

Trump announced permanent travel restrictions on citizens of Chad, Iran, Libya, North Korea, Somalia, Syria, Venezuela and Yemen. That list includes five Muslim-majority countries that were targeted in the White House’s first and second travel bans, which Trump signed in January and March. Those policies, which were designed as temporary measures, have been limited by a series of federal court rulings. [Nature News] Editorial

French Government Proposes Big Science-Spending Boost

French research funding is set for a heartening increase in the country’s first budget under President Emmanuel Macron, if draft 2018 plans are voted into law. [Nature News] Editorial

NEW 15^th Meeting of the European Section of Oncological Urology (ESOU18)
January 19-21, 2018
Amsterdam, Netherlands

Visit our events page to see a complete list of events in the community.

NEW Doctoral Student – Prostate Cancer (Lund University)

NEW Director – Stanford Cancer Institute (Stanford University)

Postdoctoral Position – Cancer Biology and Epigenetics (Duke University)

Postdoctoral Position – Cancer Immunotherapy (University of Sheffield)

Researcher – Cancer Biology (University of Cincinnati)

Postdoctoral Fellow – Prostate Disease Research (The Henry M. Jackson Foundation for the Advancement of Military Medicine)

Postdoctoral Position – Prostate Cancer (Moffitt Cancer Center)

Postdoctoral Position – Prostate Cancer (Baylor College of Medicine)

Postdoctoral Position – Prostate Related Diseases (Baylor College of Medicine)

Postdoctoral Fellow – Drug Discovery (Vancouver Prostate Centre)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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