Prostate Cell News Volume 8.38 | Oct 6 2017

TOP STORY

Mobilan: A Recombinant Adenovirus Carrying Toll-Like Receptor 5 Self-Activating Cassette for Cancer Immunotherapy

Intratumoral injection of Mobilan into subcutaneously growing syngeneic prostate tumors in immunocompetent hosts improved animal survival after surgical resection of the tumors, by suppression of tumor metastasis. Vaccination of mice with irradiated Mobilan-transduced prostate tumor cells protected mice against subsequent tumor challenge. [Oncogene] Full Article

(Ranked by impact factor of the journal)

A Regulatory Circuit HP1γ/miR-451a/C-Myc Promotes Prostate Cancer Progression

The authors found that heterochromatin protein 1γ (HP1γ) was upregulated in prostate cancer (PCa) and elevated levels of HP1γ in PCa predicted poor outcome. Depletion of HP1γ in PCa cells not only repressed proliferation and induced apoptosis but also impaired tumorigenicity. [Oncogene] Abstract

AP4 Modulated by the PI3K/AKT Pathway Promotes Prostate Cancer Proliferation and Metastasis of Prostate Cancer via Upregulating L-Plastin

Scientists performed sequential deletion and luciferase analysis of the l-plastin promoter and found that an androgen-independent regulatory factor prominently located in the region close to the transcription initiation site may facilitate l-plastin upregulation. [Cell Death Dis] Full Article

Reciprocal Amplification of Caspase-3 Activity by Nuclear Export of a Putative Human RNA-Modifying Protein, PUS10 during TRAIL-Induced Apoptosis

Researchers analyzed the role of PUS10 in TRAIL-induced apoptosis by immunofluorescence, immunoblotting and several indicators of apoptosis. They examined several TRAIL-sensitive cell lines and resistant cell lines after treatment with cycloheximide. [Cell Death Dis] Full Article

PSCA Promotes Prostate Cancer Proliferation and Cell-Cycle Progression by Up-Regulating C-Myc

Scientists explored the effect of prostate stem cell antigen (PSCA) on cell cycle of prostate cancer (PCa) cells and its mechanism. Immunohistochemistry, quantitative reverse transcription-PCR and Western blotting were used to quantify PSCA expression pattern in PCa tissues and cell lines. [Prostate] Abstract

The Unidirectional Hypoxia-Activated Prodrug OCT1002 Inhibits Growth and Vascular Development in Castrate-Resistant Prostate Tumors

Researchers tested OCT1002 alone and in combination with standard-of-care agents in hypoxic models of castrate-resistant prostate cancer. The effect of OCT1002 on tumor growth and vasculature was measured using murine PC3 xenograft and dorsal skin fold window chamber models. [Prostate] Abstract

Cynanchum wilfordii Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Regulating 5α-Reductase and Androgen Receptor Activities in a Rat Model

The authors investigated the protective effect of an aqueous extract of Cynanchum wilfordii against benign prostatic hyperplasia (BPH) development in a testosterone-induced BPH rat model. [Nutrients] Abstract

MicroRNA-588 Is Upregulated in Human Prostate Cancer with Prognostic and Functional Implications

Investigators characterized the expression, biomarker-potential and functional regulation of miR-588 in prostate cancer (PCa). Endogenous miR-588 levels were quantified by qRT-PCR in both prostate-specific antigen (PSA)-negative and PSA-positive PCa cell lines, as well as human PCa tumors. [J Cell Biochem] Abstract

Use of Real-Time Cellular Analysis and Plackett-Burman Design to Develop the Serum-Free Media for PC-3 Prostate Cancer Cells

Scientists developed a rapid strategy to screen a serum-free medium for culturing anchorage-dependent PC-3 prostate cancer cells, which was going to be prepared in large scale to generate GM-CSF/TNFα-surface-modified whole cell prostate cancer vaccine. [PLoS One] Full Article

Aryl Hydrocarbon Receptor Suppresses the Prostate Cancer LNCaP Cell Growth and Invasion by Promoting DNA Damage Response under Oxidative Stress

The authors found that exposure of LNCaP cells to H₂O₂ inhibited their viability and migration, and induced apoptosis, at a greater extent compared with the culture under normal conditions. [DNA Cell Biol] Abstract

The Role and Mechanism of Epithelial-to-Mesenchymal Transition in Prostate Cancer Progression

Epithelial-to-mesenchymal transition (EMT) is recognized in promoting cancer cells invasiveness because of high mobility and migratory abilities of mesenchymal cells once converted from carcinoma cells. Scientists reviewed the key factors involved in EMT of prostate cancer with clinical correlation. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Strata Oncology, Inc. Announces Partnership with UCSF to Launch StratifyProstate™ Initiative to Expand Access to Precision Medicine Clinical Trials for 10,000 Men with Metastatic Prostate Cancer

Strata Oncology, Inc. announced a collaboration with the University of California San Francisco (UCSF) to launch StratifyProstate™ a unique initiative focused on expanding access to tumor sequencing nationwide for men with advanced prostate cancer and to dramatically accelerate enrollment into relevant targeted therapy trials. [University of California, San Francisco] Press Release

Sophiris Bio Provides Enrollment Update on Topsalysin Phase IIb Study in Localized Prostate Cancer

Sophiris Bio Inc. provided an update on clinical trial enrollment of its Phase IIb study of topsalysin as a treatment for men with clinically significant localized prostate cancer. [Sophiris Bio Inc.] Press Release

Navajo Nation Reconsiders Ban on Genetic Research

When the Navajo Nation opens its first oncology centre next year in Tuba City, Arizona, clinicians there may be able to offer a service that has been banned on tribal lands for 15 years: analyzing the DNA of Navajo tribe members to guide treatments and study the genetic roots of disease. [Nature News] Editorial

Judge Recommends Ruling to Block Internet Access to Sci-Hub

The American Chemical Society (ACS) brought a case against Sci-Hub, a pirate site providing access to scientific articles, for copyright and trademark infringement. Following a hearing at a court in Virginia, Magistrate Judge John Anderson filed a report that recommended ruling in favor of ACS on all counts. [The Scientist] Editorial

Does Your State Get Its Fair Share of Federal Research Dollars?

The only physicist in Congress has introduced a bill that could rekindle a debate over how to deal with geographic disparities in the allocation of federal research funding. [ScienceInsider] Editorial

Scientists Plead with Brazilian Government to Restore Funding

Anxiety is growing in Brazil over the country’s collapsing research budgets. President Michel Temer had slashed funding for science by 44% in March and has proposed additional decreases for 2018 — even as some science institutes run out of money for basic needs, such as paying electricity bills. The 2017 science budget, at 3.2 billion reais (US$1 billion), is the lowest the country has seen in at least 12 years. [Nature News] Editorial

NEW 14^th Annual Stem Cell Symposium: Technology Innovation for Stem Cell Research and Therapy
February 2, 2018
Los Angeles, California, United States

Visit our events page to see a complete list of events in the community.

NEW Research Fellow – Prostate Cancer (Norwegian University of Science and Technology)

Doctoral Student – Prostate Cancer (Lund University)

Director – Stanford Cancer Institute (Stanford University)

Postdoctoral Position – Cancer Biology and Epigenetics (Duke University)

Researcher – Cancer Biology (University of Cincinnati)

Postdoctoral Fellow – Prostate Disease Research (The Henry M. Jackson Foundation for the Advancement of Military Medicine)

Postdoctoral Position – Prostate Cancer (Moffitt Cancer Center)

Postdoctoral Position – Prostate Cancer (Baylor College of Medicine)

Postdoctoral Position – Prostate Related Diseases (Baylor College of Medicine)

Postdoctoral Fellow – Drug Discovery (Vancouver Prostate Centre)

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