Prostate Cell News Volume 8.42 | Nov 3 2017

TOP STORY

Thioredoxin-1 Protects against Androgen Receptor-Induced Redox Vulnerability in Castration-Resistant Prostate Cancer

Scientists showed that the redox-protective protein thioredoxin-1 (TRX1) increases with prostate cancer progression and in androgen-deprived castration-resistant prostate cancer (CRPC) cells, suggesting that CRPC possesses an enhanced dependency on TRX1. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Anti-Angiogenic Agents

Xenograft and orthotopic models of prostate and colon cancer were used to assess the effect of PIM activation on the efficacy of VEGF-targeting agents. Immunohistochemistry and in vivo imaging were used to analyze angiogenesis, apoptosis, proliferation, and metastasis. [Clin Cancer Res] Abstract

Attomolar Detection of Extracellular MicroRNAs Released from Living Prostate Cancer Cells by a Plasmonic Nanowire Interstice Sensor

Investigators report an attomolar detection of miR141 and miR375 released from living prostate cancer cells by using a plasmonic nanowire interstice sensor. This sensor showed a very low detection limit of 100 aM as well as a wide dynamic range from 100 aM to 100 pM for all target miRNAs. [Nanoscale] Abstract | Graphical Abstract

Clinical Scale Cell-Surface Marker Independent, Acoustic Microfluidic Enrichment of Tumor Cells from Blood

Scientists demonstrated feasibility of enriching either PFA-fixed or viable cancer cells with a clinical scale acoustic microfluidic platform that can be adjusted to meet requirements for either high cancer cell recovery or higher purity, and can process five milliliter blood samples in close to two hours. [Anal Chem] Abstract

Dietary Glycation Products Regulate Immune Homeostasis: Early Glycation Products Promote Prostate Cancer Cell Proliferation through Modulating Macrophages

Early glycation products, advanced glycation end-products and their conditioned medium from macrophages were applied to human prostate cancer (PCa) cells with different etiology and murine PCa cells to determine their direct and indirect effects on PCa cell proliferation. [Mol Nutr Food Res] Abstract

Enzalutamide Inhibits Testosterone-Induced Growth of Human Prostate Cancer Xenografts in Zebrafish and Can Induce Bradycardia

Scientists determined the effects of exogenous testosterone on the growth of LNCaP, or androgen-independent C4-2 cells xenografted into zebrafish embryos. Testosterone significantly increased engrafted LNCaP proliferation compared to control xenografts, which could be inhibited by co-administration of the anti-androgen receptor drug, enzalutamide. [Sci Rep] Full Article

Synthesis and Structure–Activity Relationships of 4-Morpholino-7,8-Dihydro-5H-Thiopyrano[4,3-d]pyrimidine Derivatives Bearing Pyrazoline Scaffold

Two series of 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives bearing pyrazoline moiety were synthesized; and their cytotoxicity in vitro were evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method against four human cancer cell lines including A549; PC-3; MCF-7; and HepG2 cell lines. [Molecules] Full Article

Gallein, a Gβγ Subunit Signaling Inhibitor, Inhibits Metastatic Spread of Tumor Cells Expressing OR51E2 and Exposed to Its Odorant Ligand

The authors demonstrated that gallein can inhibit the β-ionone-induced cell invasiveness in vitro, as well as the spread of metastases in vivo. LNCaP cell invasiveness, assessed using spheroid cultures in collagen gels in vitro, was increased by β-ionone and the effect was reversed by co-administration of gallein. [BMC Res Notes] Full Article

The Inflammatory Microenvironment and Microbiome in Prostate Cancer Development

Current evidence suggests that inflammation and atrophy are involved in prostate carcinogenesis and suggests a role for the microbiome in establishing an inflammatory prostate microenvironment that might promote prostate cancer development and progression. [Nat Rev Urol] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Institut Curie and Pierre Fabre Initiate a Novel Partnership in Immuno-Oncology

Institut Curie and the Institut de Recherche Pierre Fabre will collaborate on new therapeutic strategies to advance cancer treatment for patients. The objective of this novel partnership is to dissect the biology of novel therapeutically tractable targets and evaluate the impact of innovative pharmacological approaches leveraging the Institut Curie’s biological models. [Pierre Fabre] Press Release

Minneamrita Announces FDA Clearance of Investigational New Drug (IND) Application and Initiation of a Phase I Clinical Trial of an Oral Formulation of Minnelide in Patients with Advanced Cancer

Minneamrita announced that an IND application to the FDA for a Phase I trial of an oral formulation of the company’s Minnelide for patients with advanced cancers is now active. [Minneamrita Therapeutics LLC (Business Wire, Inc.)] Press Release

House Science Chair to Retire from Congress

The controversial chairperson of the science committee in the U.S. House of Representatives announced that he will not seek re-election to Congress next fall. The pending departure of Representative Lamar Smith could give the U.S. scientific community a chance to recalibrate a rocky five-year relationship with a key congressional committee. [ScienceInsider] Editorial

Pay for US Postdocs Varies Wildly by Institution

The salary data are incomplete and — in some cases — appear to be incorrect. Some researchers are listed as earning nothing, and another study underway suggests a higher overall rate of pay for US postdocs. But the latest analysis underscores the challenges of getting basic information about an under-recognized and misunderstood segment of the academic workforce. [Nature News] Editorial

Leading Western Publisher Bows to Chinese Censorship

Springer Nature, whose publications include Nature and Scientific American, acknowledged that at the government’s request, it had removed articles from its mainland site that touch on topics the ruling Communist Party considers sensitive, including Taiwan, Tibet, human rights and elite politics. [The New York Times] Editorial

NEW European CanCer Organisation (ECCO) 2018: European Cancer Summit
September 7-9, 2018
Vienna, Austria

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Drug Discovery for Advanced Prostate Cancer (Lerner Research Institute)

PhD Studentships – Prostate Cancer (Institute of Cancer Research)

Postdoctoral Scientist – Prostate Oncobiology (CRUK Manchester Institute)

Postdoctoral Position – Cancer Biology (The Henry Ford Health System)

Doctoral Student – Prostate Cancer (Lund University)

Director – Stanford Cancer Institute (Stanford University)

Postdoctoral Position – Cancer Biology and Epigenetics (Duke University)

Researcher – Cancer Biology (University of Cincinnati)

Postdoctoral Position – Prostate Cancer (Baylor College of Medicine)

Postdoctoral Position – Prostate Related Diseases (Baylor College of Medicine)

Postdoctoral Fellow – Drug Discovery (Vancouver Prostate Centre)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Prostate Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.