Prostate Cell News Volume 8.45 | Nov 24 2017

TOP STORY

Functional Assessment of Human Enhancer Activities Using Whole-Genome STARR-Sequencing

Investigators used a human prostate cancer cell line, LNCaP as a model to perform whole human genome STARR-seq to reliably obtain an assessment of enhancer activity. [Genome Biol] Full Article

(Ranked by impact factor of the journal)

The Glucocorticoid Receptor Is a Key Player for Prostate Cancer Cell Survival and a Target for Improved Anti-Androgen Therapy

Scientists assessed glucocorticoid receptor expression and functional significance in tissues from 177 prostate cancer (PCa) patients, including 14 lymph-node metastases, as well as in several human PCa models including androgen-dependent, androgen-independent, and long-term anti-androgen-treated cell lines. [Clin Cancer Res] Abstract

Dimethylarginine Dimethylaminohydrolase-1 (DDAH1) Is Frequently Upregulated in Prostate Cancer, and Its Overexpression Conveys Tumor Growth and Angiogenesis by Metabolizing Asymmetric Dimethylarginine (ADMA)

The authors examined whether DDAH1 has any physiological role in prostate cancer (PCa) progression. Using overexpression of DDAH1 in PCa cell lines, they found that DDAH1 promotes cell proliferation, migration and invasion by lowering ADMA levels, as well as increasing nitric oxide production. [Angiogenesis] Abstract

Organoids Model Distinct Vitamin E Effects at Different Stages of Prostate Cancer Evolution

Vitamin E increased prostate cancer risk in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) through unknown mechanisms while selenium showed no efficacy. Investigators determined the effects of the SELECT supplements on benign, premalignant and malignant prostate epithelial organoids. [Sci Rep] Full Article

Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer

Scientists characterized the intracellular and extracellular metabolic profiles of four prostate cancer cell lines with varying degrees of aggressiveness. [Sci Rep] Full Article

Intracrine Prostaglandin E₂ Pro-Tumoral Actions in Prostate Epithelial Cells Originate from Non-Canonical Pathways

The authors studied the effects of prostaglandin E₂ (PGE₂) in immortalized, non-malignant prostate epithelial RWPE-1 cells and found that PGE₂ increased cell proliferation, cell migration, and production of vascular endothelial growth factor-A, and activated in vitro angiogenesis. [J Cell Physiol] Abstract

Capillarisin Blocks Prostate-Specific Antigen Expression on Activation of Androgen Receptor in Prostate Carcinoma Cells

Researchers investigated effects of capillarisin on downregulation of prostate specific antigen via modulation of androgen receptor in prostate carcinoma cells. [Prostate] Abstract

Current or Recent Smoking Is Associated with More Variable Telomere Length in Prostate Stromal Cells and Prostate Cancer Cells

The authors found no associations between smoking status and telomere length or variability in stromal cells or cancer cells. However, among men without comorbidities, current smokers and former smokers who quit <10 years ago had the most variable telomere length in stromal cells and in cancer cells. [Prostate] Abstract

Dual Inhibition of BRD4 and PI3K by SF2523 Suppresses Human Prostate Cancer Cell Growth In Vitro and In Vivo

Researchers showed that SF2523 potently inhibited survival and proliferation of primary human prostate cancer cells. SF2523 induced profound apoptosis activation in prostate cancer cells. [Biochem Biophys Res Commun] Abstract

The Dark Side of Glucose Transporters in Prostate Cancer: Are They a New Feature to Characterize Carcinomas?

The authors focus on the role of glucose transporters (GLUTs) along with prostate cancer progression, and the involvement of GLUT4 on castration-resistant phenotype transition would be considered. [Int J Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

European Commission Extends License for Janssen’s ZYTIGA Plus Prednisone/Prednisolone to Include Earlier Stage Prostate Cancer Patients

Janssen-Cilag International NV announced that the European Commission has granted approval to broaden the existing marketing authorization for ZYTIGA^® plus prednisone/prednisolone to include an earlier stage of metastatic prostate cancer than its current indications. [Janssen-Cilag International NV] Press Release

LLS Funds $46 Million in New Research to Find Cures

The Leukemia & Lymphoma Society^® (LLS) committed an additional $46 million to fund the most innovative science at leading medical institutions around the world, including Memorial Sloan Kettering Cancer Center in New York, Dana-Farber Cancer Institute in Boston, City of Hope in Duarte, California, and the Walter & Eliza Hall Institute of Medical Research in Australia. [The Leukemia & Lymphoma Society^®] Press Release

Nobel Laureates Demand Release of Iranian Scholar Facing Death Sentence

Some 75 Nobel prizewinners have called on the Iranian government to release Ahmadreza Djalali, a researcher in disaster medicine who was sentenced to death last month. The letter is the latest and most powerful protest against the ruling by the scientific community so far. [Nature News] Editorial

Still No Science Advisor at the White House

Ten months into his presidency, Donald Trump has yet to name a science advisor. It’s the longest amount of time a modern president has taken to nominate someone to the position since at least 1976, when Congress established the White House’s Office of Science and Technology Policy. [MIT Technology Review] Editorial

Director of HHS Scientific Fraud Office Is out after Stormy 2-Year Tenure

The controversial director of the office that polices research fraud in U.S.-funded biomedical labs is temporarily moving to another agency. Kathy Partin has been removed after nearly two years as director of the U.S. Office of Research Integrity in Rockville, Maryland, according to Retraction Watch. [ScienceInsider] Editorial

European Medicines Agency Will Move to Amsterdam

The European Medicines Agency, charged with evaluating human and animal medicinal products for the European Union, will relocate to Amsterdam after it was selected in a draw of lots between it and Milan. [ScienceInsider] Editorial

Hungary Rewards Highly Cited Scientists with Bonus Grants

Some top researchers prosper in Hungary as country tries to improve its international standing in science. [Nature News] Editorial

NEW 2018 Urological Society of Australia and New Zealand (USANZ) Meeting
February 24-27, 2018
Melbourne, Australia

Visit our events page to see a complete list of events in the community.

NEW PhD Studentship – Prostate Cancer (CRUK Manchester Institute)

Postdoctoral Positions – Cancer Biology (University of Pennsylvania)

Assistant Professor – Prostate Cancer (University of Illinois)

PhD Student Position – Prostate Cancer (Bellvitge Biomedical Research Institute)

Postdoctoral Position – Prostate Cancer (University of Minnesota)

Faculty Position – Cancer Research (Duke University)

Postdoctoral Position – Drug Discovery for Advanced Prostate Cancer (Lerner Research Institute)

Postdoctoral Position – Cancer Biology (The Henry Ford Health System)

Postdoctoral Position – Prostate Cancer (Baylor College of Medicine)

Postdoctoral Position – Prostate Related Diseases (Baylor College of Medicine)

Postdoctoral Fellow – Drug Discovery (Vancouver Prostate Centre)

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