Prostate Cell News Volume 8.47 | Dec 8 2017

TOP STORY

Differential Impact of RB Status on E2F1 Reprogramming in Human Cancer

Analysis of tumor samples and cell-free DNA from patients with advanced prostate cancer showed that direct retinoblastoma (RB) loss was the preferred pathway of disruption in human disease. While RB loss was associated with lethal disease, RB-deficient tumors had no proliferative advantage and exhibited downstream effects distinct from cell cycle control. [J Clin Invest] Full Article | Press Release

(Ranked by impact factor of the journal)

Androgen Receptor (AR) Degradation Enhancer ASC-J9^® in an FDA-Approved Formulated Solution Suppresses Castration Resistant Prostate Cancer Cell Growth

Preclinical studies using multiple in vitro prostate cancer (PCa) cell lines and an in vivo mouse model with xenografted castration-resistant PCa CWR22Rv1 cells demonstrated that ASC-J9^® has similar AR degradation effects when dissolved in FDA-approved solvents, including DMSO, PEG-400:Tween-80, DMA:Labrasol:Tween-80, and DMA:Labrasol:Tween-20. [Cancer Lett] Abstract

Downregulation of miR-141-3p Promotes Bone Metastasis via Activating NF-κB Signaling in Prostate Cancer

miR-141-3p expression was reduced in bone metastatic prostate cancer (PCa) tissues compared with non-bone metastatic PCa tissues. Low expression of miR-141-3p positively correlated with serum PSA levels, Gleason grade and bone metastasis status in PCa patients. Furthermore, upregulating miR-141-3p suppressed the epithelial–mesenchymal transition, invasion and migration of PCa cells in vitro. [J Exp Clin Cancer Res] Full Article

A Microsatellite Repeat in PCA3 Long Non-Coding RNA Is Associated with Prostate Cancer Risk and Aggressiveness

Scientists undertook RNA sequencing analysis of prostate tumors and adjacent non-malignant cells to identify polymorphic short tandem repeats that are readily expressed in these cells. [Sci Rep] Full Article

A Carbon 21 Steroidal Metabolite from Progestin, 20β-Hydroxy-5α-Dihydroprogesterone, Stimulates the Androgen Receptor in Prostate Cancer Cells

The authors focused on 20β-hydroxy-5α-dihydroprogesterone (20β-OHDHP), a C21s metabolized from progestin, and showed that 20β-OHDHP is synthesized in prostate cancer cells and is able to directly stimulate the androgen receptor. [Prostate] Abstract

Serum-Free Complete Medium, an Alternative Medium to Mimic Androgen Deprivation in Human Prostate Cancer Cell Line Models

LNCaP and VCaP growth was stimulated when cells were cultured in serum free media (SFM) or stripped fetal bovine serum mediam (CSM) supplemented with testosterone (T). LNCaP, C4-2, LAPC-4, and VCaP cell growth was inhibited when cultured in SFM or CSM with T and bicalutamide. [Prostate] Abstract

Cyclin-Dependent Kinase Inhibitor 3 (CDKN3) Plays a Critical Role in Prostate Cancer via Regulating Cell Cycle and DNA Replication Signaling

Investigators found that CDKN3 was highly expressed in prostate cancer and negatively correlated with disease relapse. CDKN3 positively controlled the cell proliferation in prostate carcinoma cell lines. [Biomed Pharmacother] Abstract

Hypermethylation of the SPARC Promoter and Its Prognostic Value for Prostate Cancer

Scientists investigated the abnormalities in the expression of secreted protein acidic and rich in cysteine (SPARC) and its promoter hypermethylation in prostate cancers and in correlated clinicopathological profiles. [Oncol Rep] Abstract

MiR-199a Suppresses Prostate Cancer Paclitaxel Resistance by Targeting YES1

The downregulation of miR-199a contributes to paclitaxel (PTX) resistance in prostate cancer. Yamaguchi sarcoma viral homolog 1 (YES1) mediated the regulation of miR-199a in prostate cancer PTX resistance. [World J Urol] Abstract

Prohibitin-2 Negatively Regulates AKT2 Expression to Promote Prostate Cancer Cell Migration

Researchers induced overexpression and knockdown of PHB2 in prostate cancer (PCa) cell lines with the aim of examining the effects of prohibitin-2 on PCa cell migration via wound healing assays. [Int J Mol Med] Abstract

Cross-Talk between Protein Synthesis, Energy Metabolism and Autophagy in Cancer

The authors discuss emerging findings that highlight hitherto unappreciated aspects of signaling to the translation apparatus with the particular focus on emerging connections between protein synthesis, autophagy and energy homeostasis in cancer. [Curr Opin Genet Dev] Abstract

Prostate Cancer: Updates on Current Strategies for Screening, Diagnosis and Clinical Implications of Treatment Modalities

Scientists provide the most updated information on the recent methods of prostate cancer screening, imaging and treatment modalities. Wherever possible, clinical trial data has been supplemented to provide a comprehensive overview of current prostate cancer research and development. [Carcinogenesis] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Rutgers Cancer Institute Physician-Scientist Awarded $954K for Prostate Cancer Research

Isaac Yi Kim, MD, PhD, MBA, urologic oncology section chief at Rutgers Cancer Institute of New Jersey, has been awarded a $954,000 Prostate Cancer Research Program Idea Development Award for Established Investigators from the United States Department of Defense Office of the Congressionally Directed Medical Research Program. The funding supports Dr. Kim’s research of how neuroendocrine markers impact a common treatment for a type of prostate cancer that doesn’t respond to testosterone-lowering therapies. [Rutgers Cancer Institute] Press Release

Generex Announces Collaboration with Shenzhen BioScien Pharmaceuticals to Develop and Commercialize the AE37 Immunotherapeutic Vaccine for the Treatment of Prostate Cancer in China

Generex Biotechnology Corporation announced that its wholly-owned subsidiary, Antigen Express, Inc., has entered into a License and Research Agreement with Shenzhen BioScien Pharmaceuticals Co. Ltd. to develop and commercialize the Antigen Express AE37 immunotherapeutic vaccine for prostate cancer in the People’s Republic of China. [Generex Biotechnology Corporation] Press Release

Innovus Pharma Files Application for the Commercialization of ProstaGorx^® for Benign Prostatic Hyperplasia (“BPH”) as a Natural Health Product in Canada

Innovus Pharmaceuticals, Inc. announced the filing of a Natural Health Product license application in Canada for its ProstaGorx^® product. ProstaGorx^® is a clinical strength, multi-response prostate supplement, scientifically formulated to effectively maintain good prostate health and help in preventing future prostate issues. [Innovus Pharmaceuticals, Inc.] Press Release

Brexit “Breakthrough” Draws Praise from Science Policy Experts

In laboratories throughout the UK, researchers and administrators gave out a collective sigh of relief following a decision to allow EU nationals to remain after the country leaves the union in March 2019. [Nature News] Editorial

U.S. Science Groups Make Last-Minute Push to Influence Final Tax Deal

It wasn’t your typical graduate school experience. Eight graduate students, including doctoral students in anthropology and astrophysics at major U.S. universities, ended up in handcuffs after they refused to end a noisy protest outside the Washington, D.C., office of Speaker of the House of Representatives Paul Ryan. [ScienceInsider] Editorial

US Graduate Students in Uproar over Proposed Tax Hike

Many US universities waive tuition for students who conduct research or teach. But a provision in a tax bill passed by the US House of Representatives would add that tuition to students’ taxable income. [Nature News] Editorial

NEW 11^th Dutch Stem Cell Meeting
May 4, 2018
Utrecht, Netherlands

Visit our events page to see a complete list of events in the community.

NEW Assistant/Associate Professor – Prostate Cancer (Northwestern University)

Postdoctoral Fellowship – Prostate Cancer (Duke University Medical Center)

PhD Studentship – Prostate Cancer (CRUK Manchester Institute)

Postdoctoral Positions – Cancer Biology (University of Pennsylvania)

Assistant Professor – Prostate Cancer (University of Illinois)

PhD Student Position – Prostate Cancer (Bellvitge Biomedical Research Institute)

Postdoctoral Position – Prostate Cancer (University of Minnesota)

Faculty Position – Cancer Research (Duke University)

Postdoctoral Position – Drug Discovery for Advanced Prostate Cancer (Lerner Research Institute)

Postdoctoral Position – Prostate Cancer (Baylor College of Medicine)

Postdoctoral Position – Prostate Related Diseases (Baylor College of Medicine)

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