Prostate Cell News Volume 9.04 | Feb 2 2018

TOP STORY

TRIM25 Enhances Cell Growth and Cell Survival by Modulating p53 Signals via Interaction with G3BP2 in Prostate Cancer

Researchers demonstrated that TRIM25 knockdown resulted in p53 downstream activation for cell cycle inhibition and apoptosis induction in LNCaP and 22Rv1 cells. In contrast, overexpression of TRIM25 promoted prostate cancer cell proliferation and inhibited apoptosis by docetaxel treatment in LNCaP cells. [Oncogene] Abstract

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Treatment with Docetaxel in Combination with Aneustat Leads to Potent Inhibition of Metastasis in a Patient-Derived Xenograft Model of Advanced Prostate Cancer

C4-2 cells were incubated with docetaxel, aneustat and docetaxel+aneustat to assess effects on cell migration. [Br J Cancer] Full Article

WNT5A Induces Castration-Resistant Prostate Cancer via CCL2 and Tumor-Infiltrating Macrophages

WNT5A was associated with increased expression of chemokine ligand 2 (CCL2) in the human metastatic prostate cancer cell line, LNCaP. Mechanistically, this induction of CCL2 by WNT5A was likely to be mediated via the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway. [Br J Cancer] Abstract

Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer

Investigators explored the roles of ubiquitin-specific protease 10 (USP10) in prostate cancer progression in p53, G3BP2, and androgen receptor (AR) signaling. Using chromatin immunoprecipitation and sequence analysis, they found that USP10 is transcriptionally induced with AR recruitment to an intronic region. [Mol Cancer Res] Abstract

Blockade of ACK1/TNK2 to Squelch the Survival of Prostate Cancer Stem-Like Cells

To uncover tyrosine kinase/s critical for the survival of the CD44⁺PSA^−/lo subpopulation, researchers performed an unbiased screen targeting 87 tyrosine kinases with gene specific siRNAs. Among a subset of tyrosine kinases crucial for prostate cancer stem-like cell survival, was a non-receptor tyrosine kinase, ACK1/TNK2, a critical regulator of castration resistant prostate cancer growth. [Sci Rep] Full Article

The MRPS18-2 Protein Levels Correlate with Prostate Tumor Progression and It Induces CXCR4-Dependent Migration of Cancer Cells

The authors report that expression of mitochondrial ribosomal protein S18-2 (S18-2) was increased with disease progression in clinical specimens of prostate cancer (PCa). The level of induction of epithelial to mesenchymal cell transition correlated with the expression level of S18-2 in PCa cell lines. [Sci Rep] Full Article

Osteoblast-Derived Factors Promote Metastatic Potential in Human Prostate Cancer Cells, in Part via Non-Canonical Transforming Growth Factor β (TGFβ) Signaling

Osteoblast-derived factors increased migration of PC-3U cells, an effect less prominent in cells overexpressing a mutated type I TGFβ receptor preventing non-canonical TRAF6-dependent TGFβ signaling. [Prostate] Abstract

Metastatic Prostate Cancer-Associated P62 Inhibits Autophagy Flux and Promotes Epithelial to Mesenchymal Transition by Sustaining the Level of HDAC6

P62 increased the levels of HDAC6 and reduced the acetylation of α-tubulin and the stability of microtubules. Consequently, high levels of P62 caused a promotion of epithelial-to-mesenchymal transition in addition to an impairment of autophagy flux, and further led to an enhancement of proliferation, migration, and invasion of prostate cancer cells. [Prostate] Abstract

Integrin Alpha V Beta 3 Targeted Dendrimer-Rapamycin Conjugate Reduces Fibroblast-Mediated Prostate Tumor Progression and Metastasis

Scientists report a novel dendrimer conjugate modified to deliver the mammalian target of rapamycin (mTOR) inhibitor, rapamycin. In vitro analyses demonstrated that this drug conjugate, G5-FI-RGD-rapamycin, binds to prostate cancer cells and fibroblasts to inhibit mTOR signaling and VEGF expression. [J Cell Biochem] Abstract

LncRNA PART1 Modulates Toll-Like Receptor Pathways to Influence Cell Proliferation and Apoptosis in Prostate Cancer Cells

Researchers investigated thoroughly the effect of lncRNA PART1 on prostate cancer cells proliferation and apoptosis, through regulating toll-like receptor pathways. LncRNA PART1 expression was also examined by quantitative real-time polymerase chain reactions in human tissues and the cells lines LNCaP and PC3. [Biol Chem] Abstract

Estrogen and Androgen Blockade for Advanced Prostate Cancer in the Era of Precision Medicine

The authors summarize estrogen receptor (ER) and estrogen-related receptor signaling pathways, molecular diagnosis, and selective ER modulators as candidates for advanced prostate cancer treatment. [Cancers] Full Article

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Panacea Pharmaceuticals Completes Enrollment in Phase I Study of First-in-Class Cancer Vaccine Therapy in Patients with Persistent Prostate Cancer

Panacea Pharmaceuticals announced the completion of patient enrollment in an open-label, parallel-designed, multi-center Phase I clinical trial of PAN-301-1 for the treatment of persistent prostate cancer to assess safety and immunogenicity. [Panacea Pharmaceuticals (PR Newswire Association LLC)] Press Release

Syndax Announces Immuno-Oncology Clinical Trial Collaboration with AstraZeneca

Syndax Pharmaceuticals, Inc. announced a new clinical collaboration with AstraZeneca to evaluate the safety and efficacy of AstraZeneca’s durvalumab, a human monoclonal antibody directed against programmed death-ligand 1, in combination with SNDX-6352, Syndax’s monoclonal antibody inhibitor of colony-stimulating factor 1 receptor, across a variety of solid tumors. [Syndax Pharmaceuticals, Inc.] Press Release

Bulgaria in the Cold as European Union Freezes Its Funding

European Union science ministers are due to meet in their bloc’s poorest member state — Bulgaria — to discuss future EU research policy. For the host nation, it was supposed to be a chance to showcase its ambitious plans to boost economic growth by attracting international research institutes to the country. [Nature News] Editorial

Kid Co-Authors in South Korea Spur Government Probe

The South Korean government is expanding an investigation into researchers who named their children as co-authors on papers. The extended probe comes after a government report identified 82 academic papers on which authors had named their children or relatives — many of them in middle or high school — as co-authors on the publications. [Nature News] Editorial

NEW Advances in Cell and Tissue Culture (ACTC) 2018
May 21-23, 2018
Cardiff, United Kingdom

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NEW Postdoctoral Fellow – Cancer Biology (Johns Hopkins University)

NEW Scientist – Cancer Biology (Dana-Farber Cancer Institute)

NEW Postdoctoral Research Fellow – Nuclear and Mitochondrial Mutagenesis in Carcinogenesis (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Fellow – Cancer Biology (University of Pennsylvania)

Postdoctoral Fellow – Cancer Biology (Wake Forest Baptist Comprehensive Cancer Center)

PhD Scholarships – Human Health & Emerging Environmental Contaminants (University of Hull)

PhD Positions – Cancer Imaging (University of Hull)

Professor, Tenure Canada Excellence Research Chair – Precision Cancer Drug Design (University of British Columbia)

Assistant Professor, Associate Professor & Professor – Cell & Molecular Biology (University of Mississippi)

Postdoctoral Positions – Gene Regulation and/or Cancer Biology (University of North Carolina)

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