Prostate Cell News 9.09 March 9, 2018 | |
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TOP STORYInvestigators showed that the bone microenvironment confers dormancy to C4-2B4 prostate cancer (PCa) cells as they become dormant when injected into mouse femurs but not under the skin. [Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Regulation of Inside-Out β1-Integrin Activation by CDCP1 The authors demonstrated reduced cub-domain containing protein-1 (CDCP1) expression in high-grade, primary prostate cancers, circulating tumor cells and tumor metastases of patients with castrate-resistant prostate cancer. CDCP1 was expressed in epithelial and not mesenchymal cells, and its cell surface and mRNA expression declined upon stimulation with TGFβ1 and epithelial-to-mesenchymal transition. [Oncogene] Abstract Through an RNA interference screen (RNAi), and using a prostate cancer cell line, researchers found that approximately 25% of Rho network components alter migration. Some genes enhanced migration while others decreased basal and/or hepatocyte growth factor-stimulated migration. [BMC Biol] Full Article Elevated migration, invasion, pyruvate production, lactate generation, ATP level, and impaired detachment-induced apoptosis were found in anoikis-resistant prostate cancer cells, and genome microarray analysis demonstrated that the cell migration-inducing protein (CEMIP) was a potential molecular target for the regulation of the malignant behaviors. [FASEB J] Abstract EAF2 and p53 Co-Regulate STAT3 Activation in Prostate Cancer RNA-seq analyses identified differentially regulated genes in response to concurrent knockdown of p53 and ELL-associated factor 2 (EAF2). Several of these genes were associated with the signal transducer and activator of transcription (STAT) 3 signaling pathway, and this was verified by significantly increased p-STAT3 immunostaining in the Eaf2−/−p53−/− mouse prostate. [Neoplasia] Full Article Glyoxalase 1 Sustains the Metastatic Phenotype of Prostate Cancer Cells via EMT Control Investigators uncovered a novel mechanism linking glyoxalase 1 to the maintenance of the metastatic phenotype of prostate cancer cells by controlling epithelial to mesenchymal transition (EMT) by engaging the tumor suppressor miR-101, hydroimidazolone-argpyrimidine and transforming growth factor beta 1-β1/Smad signaling. [J Cell Mol Med] Full Article To more clearly define the mechanisms involved in prostate cancer cell migration, scientists undertook a series of studies utilizing non-malignant prostate epithelial cells RWPE1 and prostate cancer DU145 and PC3 cells. They showed that increased cell migration was observed in prostate cancer cells, which was mediated through epithelial-to-mesenchymal transition. [Mol Carcinog] Abstract VDR was widely distributed in the prostatic complex at all ages analyzed, with the highest immunoexpression found in basal epithelial cells. As the animals aged, VDR levels increased, except in punctual areas with intraepithelial proliferation, metaplasia, or proliferative inflammatory atrophy, which had reduced expression of this receptor concomitantly with increased cell proliferation. [Prostate] Abstract MicroRNA-223-3p Regulates Cell Chemo-Sensitivity by Targeting FOXO3 in Prostatic Cancer The authors found that miR-223-3p was up-regulated in prostate cancer (PCa) cell lines. Transfection with miR-223-3p inhibitor increased chemo-sensitivity to docetaxel and cell apoptosis rate in PCa cells compared with docetaxel + miR-223-3p mock group, especially in DU-145 cells which were more resistant to docetaxel. [Gene] Abstract Curcumin Suppressed the Prostate Cancer by Inhibiting JNK Pathways via Epigenetic Regulation Curcumin inhibited growth of prostate cancer in vivo as well as promoted apoptosis of LNCaP cells in vitro. Curcumin inhibited JNK pathway and repressed H3K4me3 in LNCaP cells. [J Biochem Mol Toxicol] Abstract | |
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REVIEWSParallels between Hematopoietic Stem Cell and Prostate Cancer Disseminated Tumor Cell Regulation Prostate cancer disseminated tumor cells and normal hematopoietic stem cells have been shown to compete for residence in the bone marrow and share many of same regulatory mechanisms for survival, proliferation and homing. [Bone] Abstract Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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INDUSTRY NEWSEisai Co., Ltd. and Merck announced that the companies have agreed upon a strategic collaboration for the worldwide co-development and co-commercialization of LENVIMA®, an orally available tyrosine kinase inhibitor discovered by Eisai. [Merck & Co., Inc.] Press Release OncBioMune Selects Theradex as CRO for Two Phase II Trials of ProscaVax for Prostate Cancer OncBioMune Pharmaceuticals, Inc. announced that the company has selected Theradex as its contract research organization (CRO) for both the planned Phase II clinical trials evaluating the experimental immunotherapeutic vaccine ProscaVax for prostate cancer, one at Urology Centers of North Texas and the Harvard University teaching hospitals. [OncBioMune Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSScientists Win and Lose in Texas Primary Contests Texas primary was the first test for scientists seeking seats in the U.S. House of Representatives, and the results were mixed. [ScienceInsider] Editorial Behavioral ‘Violations’ Cost Prominent Neuroscientist Positions at Columbia, HHMI Prominent Columbia University neuroscientist Tom Jessell, 66, has been fired for “serious [behavioral] violations” and the university is closing his lab, the New York City institution said in a statement. The Howard Hughes Medical Institute (HHMI) in Chevy Chase, Maryland, which effectively employed Jessell, a leader in understanding neural development, also terminated him as an investigator because he “violated HHMI policy,” according to a statement from the institute. [ScienceInsider] Editorial Police Probe of Brazilian Marijuana Researcher Sparks Protests A police investigation targeting Brazil’s most prominent marijuana researcher has ignited a wave of protest among scientists. They say that the move by authorities from the state of São Paulo threatens research freedoms at a time when science in the country faces severe problems because of draconian budget cuts. [Nature News] Editorial
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EVENTSNEW Stem Cells in Disease Modelling and Drug Discovery (SCDMDD) 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Principal Scientist – Translational Research (Medivir AB) Senior Scientist – Target Discovery and Cancer Biology (Repare Therapeutics) Postdoctoral Researcher – Cancer Biology (Duke University) Postdoctoral Associate – Prostate Research (Baylor College of Medicine) Research Fellowship – Prostate Cancer Pathology (Weill Cornell Medicine) Postdoctoral Scientist Opportunities – Biomedical Research (Cedars-Sinai) Postdoctoral Scientist – Cancer Research (Boehringer Ingelheim) Postdoctoral Fellow – Cancer Biology (Johns Hopkins University) Postdoctoral Fellow – Cancer Biology (Wake Forest Baptist Comprehensive Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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