Prostate Cell News Volume 9.10 | Mar 16 2018

TOP STORY

Dual Inhibition of AKT‐mTOR and AR Signaling by Targeting HDAC3 in PTEN^‐ or SPOP‐Mutated Prostate Cancer

The authors demonstrated that HDAC3 augments AKT phosphorylation in prostate cancer cells and its overexpression correlates with AKT phosphorylation in patient samples. [EMBO Mol Med] Full Article

(Ranked by impact factor of the journal)

Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II

Scientists examined whether the acetyl CoA-calmodulin-dependent kinase II (CaMKII) pathway, first described in frog oocytes, promotes prostate cancer (PCa) tumorigenesis. In human PCa specimens, metastatic PCa expressed higher levels of active CaMKII compared to localized PCa. Correspondingly, basal CaMKII activity was significantly higher in the more tumorigenic PC3 and PC3-mm2 cells relative to the less tumorigenic LNCaP and C4-2B4 cells. [Cancer Res] Abstract

Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression

Investigators showed that CD1d-restricted invariant natural killer (iNKT) cells control prostate cancer progression by sculpting the tumor microenvironment. [Cell Rep] Full Article | Graphical Abstract

CLCA2 Epigenetic Regulation by CTBP1, HDACs, ZEB1, EP300 and miR-196b-5p Impacts Prostate Cancer Cell Adhesion and EMT in Metabolic Syndrome Disease

The authors found that C-terminal binding protein 1 (CTBP1) repressed chloride channel accessory 2 (CLCA2) expression in prostate xenografts developed in metabolic syndrome animals. CTBP1 bound to CLCA2 promoter and repressed its transcription and promoter activity in prostate cancer cell lines. [Int J Cancer] Abstract

Exosomal αvβ6 Integrin Is Required for Monocyte M2 Polarization in Prostate Cancer

Researchers showed that αvβ6 is transferred from cancer cells to monocytes, including β6^-/- monocytes, by exosomes and that monocytes from prostate cancer patients, but not from healthy volunteers, express αvβ6. [Matrix Biol] Abstract

Identification of a Novel 2-Oxindole Fluorinated Derivative as In Vivo Antitumor Agent for Prostate Cancer Acting via AMPK Activation

Investigators report the discovery of a new series of 2-oxindole derivatives whose AMPK modulatory ability, as well as the antitumoral profile in prostate cancer cells, was evaluated. [Sci Rep] Full Article

miR-206 Inhibits Proliferation and Migration of Prostate Cancer Cells by Targeting CXCL11

Scientists detected the expression levels of miR-206 in prostate cancer (PCa) tissues and PCa cell lines, and explored the potential functions of miR-206 by targeting chemokine ligand 11 (CXCL11). miR-206 was significantly under-expressed in PCa tissues and in PCa cell lines. Overexpression of miR-206 decreased the expression level of CXCL11 significantly. [Prostate] Abstract

Identification of an IL-1-Induced Gene Expression Pattern in AR⁺ PCa Cells that Mimics the Molecular Phenotype of AR⁻ PCa Cells

Comparative analysis of sequencing data from the AR⁺ LNCaP prostate cancer (PCa) cell line versus the AR⁻ PC3 PCa cell line revealed an interleukin-1 (IL-1)-conferred gene suite in LNCaP cells that is constitutive in PC3 cells. [Prostate] Abstract

Procyanidin-B2 Enriched Fraction of Cinnamon Acts as a Proteasome Inhibitor and Anti-Proliferative Agent in Human Prostate Cancer Cells

Investigators tested the potential of cinnamon and one of its active ingredients, procyanidin-B2, in inhibiting the catalytic activities of the proteasome and suppressing prostate cancer cell growth. [IUBMB Life] Abstract

Subcellular Localization of Aquaporin 3 in Prostate Cancer Is Regulated by RalA

Aquaporin 3 redistribution in PC-3 cells significantly inhibited the proliferation of cells and enhanced cell apoptosis compared with these parameters in the control. Wound healing assay and Matrigel assays determined that knockout of RalA inhibited the motility and invasion capability of PC-3 cells. [Oncol Rep] Abstract

The Role of Osteopontin in the Progression of Solid Organ Tumor

The understanding of osteopontin’s role in tumor development and progression could potentially influence cancer therapy and contribute to the development of novel anti-tumor treatments. [Cell Death Dis] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Lumenis Announces New Clinical Breakthroughs Using Its Patent-Protected MOSES Technology

Lumenis Ltd. announces the release of significant new clinical evidence in lithotripsy as well as initial clinical benefits in benign prostatic hyperplasia treatments using the MOSES^™ Technology [Press release from Lumenis Ltd. discussing research to be presented at the 33^rd Annual European Association of Urology Congress (EAU18), Copenhagen] Press Release

Sheffield Scientists Win Crucial Grants to Take Forward Prostate Cancer Research

Two grants totalling £600,000 awarded to pioneering prostate cancer research projects at the University of Sheffield. The innovative research aims to stop the spread of cancer and prevent the disease from growing back after primary treatment. [University of Sheffield] Press Release

Boehringer Ingelheim and Vanderbilt University Expand Partnership to Develop Novel Treatment Approaches for Cancer

Boehringer Ingelheim and Vanderbilt University announced the expansion of their successful existing collaboration to develop novel anti-cancer compounds. The expanded research partnership will focus on the discovery and development of new chemical therapeutics targeting the pro-survival protein MCL1 as a potential therapy against MCL1-dependent cancers. [Vanderbilt University] Press Release

Scientists Beware: The Price Is High, the Payoff Uncertain at Glossy Publications Aimed at Europe’s Decision-Makers

Van der Heyden isn’t the only European researcher to get a hard sell from Pan European Networks, a six-year-old publishing company with offices in Congleton, U.K., and Brussels that promises to provide opportunities for “leading figures from across Europe” to get attention for their work or ideas. Many other scientists had similar experiences, Van der Heyden discovered when he started poking around on blogs and Twitter, including the promise of attention from decision-makers and the warning about the imminent board meeting. [ScienceInsider] Editorial

‘Right-to-Try’ Bill Rejected by House, in Major Blow to GOP Efforts

In a major blow to the effort to pass a federal “right-to-try” law, House Republicans failed to muster the votes to pass a key compromise measure. [STAT News] Editorial

Springer Nature and VSNU Renew Agreement on Open Access Publishing

Springer Nature and the Association of Universities in the Netherlands (VSNU) have renewed their agreement to secure open access publishing for Dutch universities up to 2021. [The Association of Universities in the Netherlands] Editorial

Science ‘Champion’ Dan Lipinski Faces Tough Race in Illinois Primary

Representative Daniel Lipinski—an anti-abortion Democrat who voted against the Affordable Care Act and who only recently has embraced a path to citizenship for undocumented immigrants—knows that he’s out of step with progressives on many social issues. Lipinski will find out whether voters in Illinois’s third congressional district on Chicago’s southwest side feel there’s still room for him in the Democratic Party. [ScienceInsider] Editorial

NEW Gordon Research Conferences: Notch Signaling in Development, Regeneration and Disease
July 22-27, 2018
Lewiston, Maine, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Drug Development for Cancer (KU Leuven)

Principal Scientist – Translational Research (Medivir AB)

Senior Scientist – Target Discovery and Cancer Biology (Repare Therapeutics)

Postdoctoral Researcher – Cancer Biology (Duke University)

Postdoctoral Associate – Prostate Research (Baylor College of Medicine)

Research Fellowship – Prostate Cancer Pathology (Weill Cornell Medicine)

Postdoctoral Scientist Opportunities – Biomedical Research (Cedars-Sinai)

Postdoctoral Fellow – Prostate Disease Research (Henry M. Jackson Foundation for the Advancement of Military Medicine)

Postdoctoral Scientist – Cancer Research (Boehringer Ingelheim)

Postdoctoral Fellow – Cancer Biology (Johns Hopkins University)

Postdoctoral Research Fellow – Nuclear and Mitochondrial Mutagenesis in Carcinogenesis (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Cancer Biology (Wake Forest Baptist Comprehensive Cancer Center)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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