Prostate Cell News 9.13 April 13, 2018 | |
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TOP STORYStudy Finds How Fat Tissue Shunts Energy to Tumors Researchers revealed that inactivation of a protein called p62 in fat cells fuels aggressive, metastatic prostate cancer in mice. p62 deficiency triggered a shutdown of energy-consuming processes in fat tissue, thereby increasing the availability of nutrients for cancer cells. [Press release from the Sanford Prebys Medical Discovery Institute discussing online prepublication in Cancer Cell] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Prostate Specific Membrane Antigen Targeted Gold Nanoparticles for Theranostics of Prostate Cancer In vitro cellular uptake experiments demonstrated significantly higher nanoparticle uptake in prostate-specific membrane antigen (PSMA)-positive PC3pip cells than in PSMA-negative PC3flu cells. [ACS Nano] Abstract Scientists combined mass spectrometry-based proteomic analyses with a unique patient-derived explant model that retains the complex microenvironment of primary prostate tumors. [Mol Cell Proteomics] Abstract | Full Article Monoamine Oxidase Deficiency Causes Prostate Atrophy and Reduces Prostate Progenitor Cell Activity Investigators showed that mice lacking both monoamine oxidase (MAO) isoforms, MAOA and MAOB, exhibit smaller prostate mass and develop epithelial atrophy in the ventral and dorsolateral prostates. [Stem Cells] Abstract Overexpressed MALAT1 promoted cell proliferation, migration and invasion but decreased cell apoptosis rate of prostate cancer cells in spite of docetaxel treatment. [J Cell Mol Med] Abstract Both PNT1A and PC3 cells had greater proliferation when treated with palmitate (HF), while insulin (HI) treatment stimulated only PNT1A. Metformin inhibited cell proliferation caused by HF in both cell lines, but it did not block the proliferative action of HI in PNT1A cells. [Prostate] Abstract Anticancer Activity of Anthopleura anjunae Oligopeptides in Prostate Cancer DU-145 Cells Scientists investigated the inhibitory effects of A. anjunae anti-tumor peptide on prostate cancer DU-145 cell proliferation using a methylthiazolyldiphenyl-tetrazolium bromide assay. [Mar Drugs] Full Article Investigators characterized the placental-derived stem cell exosomes and evaluated their anti-cancer efficacy in prostate cancer cell lines. [Biochem Biophys Res Commun] Abstract Re-Expression of MicroRNA-4319 Inhibits Growth of Prostate Cancer via Her-2 Suppression miR-4319 levels were decreased in prostate cancer specimens, compared to corresponding normal prostate tissue. Lower levels of miR-4319 were correlated with poorer overall patients’ survival. In vitro, the cell survival mediated with Her-2 against chemotherapy was inhibited by overexpression of miR-4319 and was enhanced by depletion of miR-4319. [Clin Transl Oncol] Abstract | |
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REVIEWSRole of Stromal Paracrine Signals in Proliferative Diseases of the Aging Human Prostate Scientists summarize the role of stromal paracrine signals in proliferative diseases of the aging human prostate and discuss the potential clinical applications of carcinoma-associated fibroblast-derived exosomal microRNAs as promising biomarkers. [J Clin Med] Full Article Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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SCIENCE NEWSQIAGEN Launches AdnaTest Liquid Biopsy Kits in Prostate and Lung Cancer QIAGEN N.V. launched two novel liquid biopsy panels to evaluate circulating tumor cells in the growing field of research into molecular mechanisms in prostate and lung cancers. [Press release from QIAGEN N.V. discussing research to be presented at the American Association for Cancer Research (AACR) 2018 Annual Meeting, Chicago] Press Release | |
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INDUSTRY NEWSTheresa May Announces £75m Funding Boost for Prostate Cancer Prime minister Theresa May has announced an additional £75m in funding for “earlier and faster” diagnosis and treatment of prostate cancer, which kills more than 10,000 men each year. [Independent] Press Release UMN Receives $42.6 Million to Expand Impact on Scientific Health Research The University of Minnesota’s Clinical and Translational Science Institute received more than $42 million in renewed National Institutes of Health funding through the National Center for Advancing Translational Sciences’ Clinical and Translational Science Award program. [The University of Minnesota] Press Release | |
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POLICY NEWSPanel Calls for a Postdoc Tax and Other Measures to Help Biomedical Scientists Find Jobs The U.S. Congress, federal funding agencies, universities, and other research institutions must take significant steps, such as a postdoc “tax” and a hard cap on how long postdocs can be funded by a lab head, to better usher young biomedical scientists into viable careers, a committee from the National Academies of Sciences, Engineering, and Medicine concluded in a report. [ScienceInsider] Editorial Spain’s Biggest-Ever Science Petition Decries ‘Abandonment’ of Research Leading Spanish scientific organizations delivered a petition signed by more than 277,000 people to the national parliament in Madrid, calling on the government to stop the “progressive abandonment of science in Spain” caused by budget cuts. The petition is the largest ever on a science-policy subject in Spain. [Nature News] Editorial The March for Science Is Back — and Here’s What to Expect Nature takes a look at why people are marching, how the movement has changed over time and what its future could bring. [Nature News] Editorial India Creates Unique Tiered System to Punish Plagiarism The Indian government has adopted its first regulations on academic plagiarism—rules that some researchers say are too lenient and others fear go too far and will be difficult to implement. [ScienceInsider] Editorial
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EVENTSNEW 6th Annual German Stem Cell Network (GSCN) Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellows – Prostate Cancer (Thomas Jefferson University) Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK Manchester Institute) Postdoctoral Fellows – Molecular and Translational Cancer Biology (Thomas Jefferson University) Postdoctoral Position – Prostate Cancer (Northwestern University) Research Scientist – Prostate Cancer (Institute of Oncology Research) Postdoctoral Position – Drug Development for Cancer (KU Leuven) Principal Scientist – Translational Research (Medivir AB) Postdoctoral Researcher – Cancer Biology (Duke University) Postdoctoral Associate – Prostate Research (Baylor College of Medicine) Research Fellowship – Prostate Cancer Pathology (Weill Cornell Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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