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Pulmonary Cell News| Prostate Cell News 9.16 May 4, 2018 | |
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TOP STORYDevelopment of a Stress Response Therapy Targeting Aggressive Prostate Cancer Using murine and humanized models of prostate cancer, investigators showed that one of the three branches of the unfolded protein response is selectively activated in advanced prostate cancer. [Sci Transl Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)TRAF4-Mediated Ubiquitination of NGF Receptor TrkA Regulates Prostate Cancer Metastasis Researchers showed that non-proteolytic ubiquitination of receptor tyrosine kinases (RTK) regulates its kinase activity and contributes to RTK-mediated prostate cancer metastasis. TRAF4, an E3 ubiquitin ligase, was highly expressed in metastatic prostate cancer. [J Clin Invest] Abstract | Full Article Frizzled-8 Integrates Wnt-11 and Transforming Growth Factor-β Signaling in Prostate Cancer Scientists provided evidence that frizzled-8 (FZD8) is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote epithelial-to-mesenchymal transition. FZD8 mRNA was upregulated in multiple prostate cancer datasets and in metastatic cancer cell lines in vitro and in vivo. [Nat Commun] Full Article While JMJD1A knockdown had no effect on full-length androgen receptor (AR-FL), it reduced AR-V7 levels in prostate cancer cells. Reexpression of AR-V7 in the JMJD1A-knockdown cells elevated expression of select AR targets and partially rescued prostate cancer cell growth in vitro and in vivo. [Proc Natl Acad Sci USA] Abstract Tunable Cytotoxic Aptamer–Drug Conjugates for the Treatment of Prostate Cancer Cell selection for aptamers with prostate cancer specificity yielded the E3 aptamer, which internalized into prostate cancer cells without targeting normal prostate cells. Chemical conjugation of E3 to the drugs monomethyl auristatin E and monomethyl auristatin F yielded a potent cytotoxic agent that efficiently killed prostate cancer cells in vitro but did not affect normal prostate epithelial cells. [Proc Natl Acad Sci USA] Abstract Depletion of MEIS1 and MEIS2 resulted in increased tumor growth over time in vivo, and decreased MEIS expression in both patient-derived tumors and MEIS-depleted cell lines was associated with increased expression of the pro-tumorigenic genes cMYC and CD142, and decreased expression of AXIN2, FN1, ROCK1, SERPINE2, SNAI2, and TGFb2. [Clin Cancer Res] Abstract Antagonizing CD105 Enhances Radiation Sensitivity in Prostate Cancer Investigators identified a novel synthetic lethality strategy of combining radiation and CD105 targeting to address the DNA repair and metabolic addiction induced by irradiation in p53-functional prostate cancers. [Oncogene] Full Article The Essential Role of WD Repeat Domain 77 in Prostate Tumor Initiation Induced by Pten Loss Scientists used in vivo genetic studies to further investigate the role of WD repeat domain 77 (Wdr77) in prostate tumorigenesis. They found that prostate-specific deletion of Wdr77 abolished prostate tumor initiation induced by loss of the tumor suppressor Pten. [Oncogene] Abstract Researchers discovered that polo-like kinase 1 (Plk1) inhibition causes activation of the β-catenin pathway and increased expression of c-Myc, eventually resulting in resistance to Plk1 inhibition. [Mol Cancer Ther] Abstract Investigators report that treatment of cancer cells with propranolol in combination with the glycolysis inhibitor 2DG induced a massive accumulation of autophagosome due to autophagy blockade. [Sci Rep] Full Article Scientists used an androgen-sensitive human prostate cancer (PCa) cell line and its sublines to investigate the relationship between the responsiveness of PCa cells to interleukin‐6 treatment and the cellular androgen receptor signaling pathway. [Prostate] Abstract Montelukast Inhibits Hypoxia Inducible Factor-1α Translation in Prostate Cancer Cells The authors showed that montelukast, a clinical leukotriene receptor antagonist for the treatment of asthma, inhibits hypoxia or CoCl2-induced hypoxia-inducible factor -1α activation and reduces its protein expression in prostate cancer cells. [Cancer Biol Ther] Abstract | |
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REVIEWSCirculating Tumor Cell Analysis in Preclinical Mouse Models of Metastasis Scientists discuss the use of circulating tumor cell (CTC) analysis as an effective means of tracking and characterizing metastatic disease progression in preclinical mouse models of breast and prostate cancer and the resulting lessons learned about CTC and metastasis biology. [Diagnostics (Basel)] Full Article Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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INDUSTRY NEWSCU Anschutz Wins $46.5 Million NIH Grant The National Institutes of Health (NIH) recently awarded $46.5 million to the University of Colorado Anschutz Medical Campus and its Colorado Clinical and Translational Sciences Institute, a research partnership designed to speed up development of new treatments to address the greatest health needs of Coloradans. [University of Colorado Anschutz Medical Campus] Press Release NanOlogy LLC has completed the dose escalation phase of an open-label clinical trial of NanoPac injected directly into the tumor area for treatment of prostate cancer. [NanOlogy LLC] Press Release | |
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POLICY NEWSNature Announces New Editor-in-Chief Nature has named Magdalena Skipper as its new editor-in-chief. She is the first woman to hold the post. Skipper, who is currently editor-in-chief of the open-access journal Nature Communications, will become the eighth editor of Nature. [Nature News] Editorial Big UK Science Funder Says Report Harassment or Risk Losing Funding One of the world’s largest research-funding charities is cracking down on harassment and bullying. Scientists who have been sanctioned by their institutions could lose out on funding from the Wellcome Trust, under rules announced. [Nature News] Editorial Nature Journals Formalize Ethical Standards for Human Embryo and Stem-Cell Research Nature journals encourage stem-cell scientists to embrace guidelines agreed in 2016 by the International Society for Stem Cell Research as they design, execute and report their research. [Nature News] Editorial Accused Cancer Scientist Resigns as Editor of Prestigious Journal Inder Verma, the prominent cancer scientist and geneticist who has been accused of sexual harassment by several women, resigned yesterday as editor-in-chief of the Proceedings of the National Academy of Sciences, a prestigious academic journal. [ScienceInsider] Editorial
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EVENTSNEW 3D Cell Culture 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Academic Position – Cancer Research (Cedars-Sinai Medical Center) NEW Tenure-Track Faculty Position – Cancer Research (University of Ottawa) NEW Postdoctoral Fellow – Prostate Cancer (Moffitt Cancer Center) Postdoctoral Fellow – Prostate Cancer Epigenomics (Northwestern University) Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK Manchester Institute) Postdoctoral Fellows – Molecular and Translational Cancer Biology (Thomas Jefferson University) Postdoctoral Position – Prostate Cancer (Northwestern University) Postdoctoral Associate – Prostate Research (Baylor College of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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