Prostate Cell News Volume 9.27 | Jul 20 2018

TOP STORY

Leveraging Gamma-Glutamyl Transferase to Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells

GGTDTC was found to be stable to non‐specific degradation when incubated with a series of prostate cancer and normal cell lines, with selective release of diethyldithiocarbamate only occurring in cells with measurable gamma-glutamyl transferase activity. [Angew Chem Int Ed Engl] Abstract

(Ranked by impact factor of the journal)

Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration

Metformin was capable of inhibiting the following processes: inflammatory infiltration after ADT induced by surgically castration in mice, bicalutamide treatment in patients and hormone deprivation in LNCaP cells. Mechanistically, metformin repressed inflammatory infiltration by downregulating both COX2 and PGE2 in tumor cells. [Clin Cancer Res] Abstract

IFNL4-ΔG Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer

Investigators showed that the interferon λ4 germline variant (IFNL4-ΔG) allele was significantly associated with “interferon-related DNA damage resistance signature” (IRDS) in prostate tumors and overall survival of African-American patients. IFNL4 overexpression induced IRDS in three human prostate cancer cell lines. [Clin Cancer Res] Abstract

BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer

BMX contributed to castration-resistant prostate cancer development in cell line and xenograft models by positively regulating the activities of multiple receptor tyrosine kinases through phosphorylation of a phosphotyrosine-tyrosine (pYY) motif in their activation loop, generating pYpY that is required for full kinase activity. [Cancer Res] Abstract

Transcriptional Downregulation of miR-133b by REST Promotes Prostate Cancer Metastasis to Bone via Activating TGF-β Signaling

The authors reported that miR-133b was downregulated in prostate cancer (PCa) tissues and further decreased in bone metastatic PCa tissues. They found that miR-133b suppressed activity of TGF-β signaling via directly targeting TGF-β receptor I and II, which further inhibited bone metastasis of PCa cells. [Cell Death Dis] Full Article

PARP Inhibitor Veliparib and HDAC Inhibitor SAHA Synergistically Co-Target the UHRF1/BRCA1 DNA Damage Repair Complex in Prostate Cancer Cells

Veliparib or SAHA alone reduced BRCA1 or UHRF1 protein levels, co-treatment with veliparib and SAHA synergistically reduced BRCA1 protein levels by targeting the UHRF1/BRCA1 protein complex, the depletion of UHRF1 resulted in the degradation of BRCA1 protein, while the elevation of UHRF1 impaired co-treatment-reduced BRCA1 protein levels. [J Exp Clin Cancer Res] Full Article

Downregulation of miR-133a-3p Promotes Prostate Cancer Bone Metastasis via Activating PI3K/AKT Signaling

Upregulating miR-133a-3p inhibited cancer stem cell-like phenotypes in vitro and in vivo, as well as attenuated anoikis resistance in vitro in prostate cancer (PCa) cells. Importantly, administration of agomir-133a-3p greatly suppressed the incidence of PCa bone metastasis in vivo. [J Exp Clin Cancer Res] Full Article

Regulation of ELL2 Stability and Polyubiquitination by EAF2 in Prostate Cancer Cells

Elongation factor for RNA polymerase 2 (ELL2) protein was downregulated in prostate cancer specimens and was up‐regulated by androgens in prostate cancer cell lines LNCaP and C4‐2. ELL2 knockdown enhanced prostate cancer cell proliferation and motility. ELL2 protein has a short half‐life and was stabilized by proteasome inhibitor MG132. [Prostate] Abstract

Exendin-4 Enhances Radiation Response of Prostate Cancer

Researchers found that GLP‐1 receptor was expressed in human prostate cancer (PC) tissues and cell lines. One‐100 nM exendin‐4 promoted the anti‐proliferation effects of ionizing radiation in vitro and in vivo, and enhanced radiation‐induced G2/M cycle arrest in PC cells in a dose‐dependent manner. Ex‐4 increased AMPK phosphorylation, decrease the levels of p‐mTOR, cyclin B, and p34^cdc2. [Prostate] Abstract

Subscribe to one of our other 19 science newsletters such as Mammary Cell News & ESC & iPSC News.

Diverse Roles of Fatty Acid Binding Proteins (FABPs) in Development and Pathogenesis of Cancers

FABPs are expressed in most malignancies such as prostate, breast, liver, bladder and lung cancer which are associated with the incidence, proliferation, metastasis, invasion of tumors. The authors introduce several isoforms of FABPs and summarize their function and their possible roles in cancer development through some proposed mechanisms. [Gene] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Keck School to Lead First Large-Scale Study on African-American Men with Prostate Cancer

The Keck School of Medicine of USC is leading a $26.5 million effort to conduct the first large-scale, multi-institutional study on African-American men with prostate cancer to better understand why they are at higher risk for developing more aggressive forms of the disease and why they are more likely to die from it. Researchers hope to recruit 10,000 African-American men nationwide to participate in the study. [Keck School of Medicine of USC] Press Release

Prostate Cancer Researchers Awarded Spot in National Consortium

Weill Cornell Medicine, in collaboration with Columbia University Irving Medical Center and NewYork-Presbyterian, has been awarded a grant of more than $900,000 from the U.S. Department of Defense to conduct prostate cancer clinical trials. [Weill Cornell Medicine] Press Release

Philippines Sweetens Deal for Scientists Who Return Home

A renewed government effort to draw Filipino scientists back to the Philippines by paying them to set up their own research labs or teach has met with a mixed reception. [Nature News] Editorial

Dutch Publishing Giant Cuts Off Researchers in Germany and Sweden

Elsevier stopped thousands of scientists in Germany from reading its recent journal articles, as a row escalates over the cost of a nationwide open-access agreement. The move comes just two weeks after researchers in Sweden lost access to the most recent Elsevier research papers, when negotiations on its contract broke down over the same issue. [Nature News] Editorial

Hungarian Academy President Vows to Keep Fighting for Independence as Government Takes Control

Hungary’s parliament approved an amendment that makes it legally possible to transfer a large part of the budget of the Hungarian Academy of Sciences in Budapest to the country’s newly established Ministry of Innovation and Technology. [ScienceInsider] Editorial

New Policy Aims to Free Scientists to Focus on Research, Avoid Jumping through Hoops

Chinese scientific researchers are to be evaluated on the valuable contributions they make to their field rather than their number of published papers or academic credentials, according to a new policy issued by China’s top officials. The new policy is considered by experts to be the first volley of China’s resistance to efforts by the U.S. to suppress its high-tech development. [Chinanews.com] Editorial

NEW 19th Asia-Pacific Prostate Cancer Conference 2018
August 22-25, 2018
Brisbane, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Tumor Ecosystem Research (University of Zurich)

NEW Postdoctoral Felllow – Non-Coding RNA & Cancer Research (Universtiy of Toronto)

Research Fellowship – Prostate Cancer Pathology (Weill Cornell Medicine)

Postdoctoral Fellow – Prostate Cancer Metastasis Research (Oregon Health & Science University)

Postdoctoral Fellow – Molecular Mechanisms of Prostate Cancer (Northwestern University Feinberg School of Medicine)

Postdoctoral Fellow – Prostate Cancer Development & Progression Research (Brigham & Women’s Hospital-Harvard Medical School)

Postdoctoral Fellow – Cancer Research (Princess Margaret Cancer Centre)

Postdoctoral Positions – Ribosome Modifications (University of Copenhagen)

Research Fellow – Prostate Cancer (Sechenov University)

Postdoctoral Fellow – Prostate Cancer (Moffitt Cancer Center)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Prostate Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.