LABORATORY RESEARCH The Inhibitory Effects of AR/miR-190a/YB-1 Negative Feedback Loop on Prostate Cancer and Underlying Mechanism Researchers observed androgen receptor (AR)/miR-190a/YB-1 forms an auto-regulatory negative feedback loop in prostate cancer: miR-190a expression was down-regulated by AR activation; YB-1 functions are as an AR activator; miR-190a inhibited AR expression and transactivation through direct binding to 3′UTR of YB-1 gene. [Sci Rep] Full Article A Novel Recombinant Slow-Release TNF α-Derived Peptide Effectively Inhibits Tumor Growth and Angiogenesis RMP16 had significant inhibition effects for multiple tumor cells, especially prostate cancer Du145 cells, and human vascular endothelial cells but not for human mammary non-tumorigenic epithelial cells. [Sci Rep] Full Article MicroRNA Expression Signature of Castration-Resistant Prostate Cancer: The MicroRNA-221/222 Cluster Functions as a Tumor Suppressor and Disease Progression Marker Researchers investigated the functional roles of microRNA (miRNA)-221 and miRNA-222 in prostate cancer cells. Restoration of miR-221 or miR-222 in cancer cells revealed that both miRNAs significantly inhibited cancer cell migration and invasion. [Br J Cancer] Abstract ATM Inhibition Potentiates Death of Androgen Receptor-Inactivated Prostate Cancer Cells with Telomere Dysfunction Since telomere dysfunction in other systems is known to activate ATM (ataxia telangiectasia mutated)-mediated DNA damage response (DDR) signaling pathways, scientists investigated the role of ATM-mediated DDR signaling in androgen receptor-inactivated prostate cancer cells. [J Biol Chem] Abstract | Full Article Anti-Tumor Effect of the Alphavirus-Based Virus-Like Particle Vector Expressing Prostate-Specific Antigen in a HLA–DR Transgenic Mouse Model of Prostate Cancer Researchers determined if an alphavirus-based vaccine encoding human prostate-specific antigen (PSA) could generate an effective anti-tumor immune response in a stringent mouse model of prostate cancer. They found that virus-like particle vector encoding PSA could infect mouse dendritic cells in vitro and induce a robust PSA-specific immune response in vivo. [Vaccine] Abstract Cyanidin Induces Apoptosis and Differentiation in Prostate Cancer Cells Researchers delineated the anti-proliferative activity and the cytodifferentiation properties mediated by cyanidin-3-O-β-glucopyranoside (C3G) treatment in the DU145 and LnCap human prostatic cancer cell lines. C3G produced anti-proliferative effects through activation of caspase-3 and induction of p21 protein expression. [Int J Oncol] Abstract The Resveratrol Tetramer r-Viniferin Induces a Cell Cycle Arrest Followed by Apoptosis in the Prostate Cancer Cell Line LNCaP Scientists investigated the cytotoxic/growth-inhibiting properties of the resveratrol tetramer r-viniferin on the prostate cancer cell line LNCaP and compared them with those of resveratrol. [Phytother Res] Abstract Cardiolipin Composition Correlates with Prostate Cancer Cell Proliferation Investigators analyzed the interrelationship between cardiolipin (CL) composition and the proliferation of prostate cells by exposing PC-3 tumor cells to different fatty acids and by analyzing the CL composition in prostate tissue from prostate cancer patients after prostatectomy. [Mol Cell Biochem] Abstract CLINICAL RESEARCH Comparison of Two Adjuvant Hormone Therapy Regimens in Patients with High-Risk Localized Prostate Cancer after Radical Prostatectomy: Primary Results of Study CU1005 Researchers evaluated two regimens of maximum androgen blockage or bicalutamide 150 mg daily as immediate adjuvant therapy for high-risk localized prostate cancer. [Asian J Androl] Full Article |