Pulmonary Cell News Volume 10.00 | Jan 7 2021

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    2020-07-01 | PULCN 10.00


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.00 – 7 January, 2021
    TOP STORY

    The Aging Transcriptome and Cellular Landscape of the Human Lung in Relation to SARS-CoV-2

    Deconvolution analyses revealed that the proportions of alveolar type 2 cells, proliferating basal cells, goblet cells, and proliferating natural killer/T cells decreased with age, whereas alveolar fibroblasts, pericytes, airway smooth muscle cells, endothelial cells and IGSF21+ dendritic cells increased with age.
    [Nature Communications]

    Full Article

    Explore scientific events this January with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    Lipid Peroxidation, GSH Depletion, and SLC7A11 Inhibition Are Common Causes of EMT and Ferroptosis in A549 Cells, but Different in Specific Mechanisms

    The authors showed that ferroptosis in A549 cells was induced by Erastin, which decreased the expression levels of E-cadherin, α-SMA, and SLC7A11, accompanied with reactive oxygen species and malondialdehyde increase, as well as glutathione decrease.
    [DNA and Cell Biology]

    Abstract

    Dual Inhibition of MEK and AXL Targets Tumor Cell Heterogeneity and Prevents Resistant Outgrowth Mediated by the Epithelial-to-Mesenchymal Transition in NSCLC

    Researchers integrated the data from a selective drug screen in epithelial and mesenchymal Kras/p53 mutant lung tumor cells with separate datasets including reverse phase protein array and an in vivo shRNA dropout screen.
    [Cancer Research]

    Abstract

    Intermittent Hypoxia-Induced Downregulation of MicroRNA-320b Promotes the Lung Cancer Tumorigenesis by Increasing CDT1 via USP37

    Scientists explored the functional roles of microRNAs in lung cancer patients that were complicated with obstructive sleep apnea-hypopnea involving the deubiquitination enzyme. The miR-320b expression pattern in lung cancer tissues and cells was determined.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    Extracellular Vesicles‐Encapsulated let‐7i Shed from Bone Mesenchymal Stem Cells Suppress Lung Cancer via KDM3A/DCLK1/FXYD3 Axis

    Researchers investigated the modulatory role of bone marrow mesenchymal stem cell‐extracellular vesicle‐derived let‐7i and their molecular mechanism in lung cancer progression.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    ZCCHC14 Regulates Proliferation and Invasion of Non–Small Cell Lung Cancer through the MAPK‐P38 Signaling Pathway

    The authors explored the expression, function and related molecular mechanisms of ZCCHC14 in human NSCLC.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Restored MicroRNA-519a Enhances the Radiosensitivity of Non-Small Cell Lung Cancer via Suppressing EphA2

    Researchers investigated the role of miR-519a-targeted ephrinA2 receptor in radiosensitivity of NSCLC. miR-519a and EphA2 expression in NSCLC and paracancerous tissues were detected using RT-qPCR and western blot analysis.
    [Gene Therapy]

    Abstract

    Cyclophilin A Inhibits A549 Cell Oxidative Stress and Apoptosis by Modulating the PI3K/Akt/mTOR Signaling Pathway

    Scientists showed the protective effect of human recombinant CypA on hydrogen peroxide-induced oxidative damage in A549 cells, which played crucial roles in lung cancer.
    [Bioscience Reports]

    Abstract

    Exosomal miR‐3180‐3p Inhibits Proliferation and Metastasis of Non‐Small Cell Lung Cancer by Downregulating FOXP4

    Researchers found that miR‐3180‐3p decreased in two NSCLC cell lines and patient tissues. Overexpression of miR‐3180‐3p or treatment with exosomal miR‐3180‐3p significantly suppressed cell proliferation and metastasis in NSCLC cell lines.
    [Thoracic Cancer]

    Full Article

    Tools and products for your COVID-19 research.
    REVIEWS

    Alveolar Progenitor Cells and the Origin of Lung Cancer

    Scientists focus on alveolar type 2 cells as the cell of origin of lung adenocarcinoma (LUAD), the most common type of lung cancer. They elaborate on the different oncogenes that are associated with LUAD and other lung cancers.
    [Journal of Internal Medicine]

    Abstract

    INDUSTRY AND POLICY NEWS

    Genentech’s Novel Anti-TIGIT Tiragolumab Granted FDA Breakthrough Therapy Designation in Combination with Tecentriq for PD-L1-High Non-Small Cell Lung Cancer

    Genentech announced that tiragolumab, a novel cancer immunotherapy designed to bind to TIGIT, has been granted Breakthrough Therapy Designation by the FDA, in combination with Tecentriq® for the first-line treatment of people with metastatic NSCLC whose tumors have high PD-L1 expression with no EGFR or ALK genomic tumor aberrations.
    [Genentech]

    Press Release

    FEATURED EVENT

    ISEV Infectious Diseases Meeting

    January 25 – 28, 2021
    Virtual

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    JOB OPPORTUNITIES

    Scientific Communities & Communications Specialist

    STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada

    Postdoctoral Fellowship – Stem Cell Biology/Lung Biology

    University of California, San Francisco – San Francisco, California, United States

    Postdoctoral Fellowship – Lung Cancer Research

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow Position – Host-Pathogen Interactions

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Postdoctoral Fellowship – Pro-Metastatic Tumor Microenvironment

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    > See All Jobs

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