Pulmonary Cell News Volume 10.01 | Jan 14 2021

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    2020-14-01 | PULCN 10.01


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.01 – 14 January, 2021
    TOP STORY

    A Novel ACE2 Isoform Is Expressed in Human Respiratory Epithelia and Is Upregulated in Response to Interferons and RNA Respiratory Virus Infection

    Researchers identified a novel short isoform of angiotensin-converting enzyme 2 (ACE2) expressed in the airway epithelium, the main site of SARS-CoV-2 infection. Short ACE2 was substantially upregulated in response to interferon stimulation and rhinovirus infection, but not SARS-CoV-2 infection.
    [Nature Genetics]

    Full Article

    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    AXL Is a Candidate Receptor for SARS-CoV-2 That Promotes Infection of Pulmonary and Bronchial Epithelial Cells

    Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2, scientists found that overexpression of AXL in HEK293T cells promoted SARS-CoV-2 entry as efficiently as overexpression of ACE2, while knocking out AXL significantly reduced SARS-CoV-2 infection in H1299 pulmonary cells and in human primary lung epithelial cells.
    [Cell Research]

    Full Article

    MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

    The authors found that SARS-CoV-2 replication induced a delayed interferon response in lung epithelial cells. By screening 16 putative sensors involved in sensing of RNA virus infection, they found that MDA5 and LGP2 primarily regulated IFN induction in response to SARS-CoV-2 infection.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Generation of a New Immortalized Human Lung Pericyte Cell Line: A Promising Tool for Human Lung Pericyte Studies

    Investigators established an immortalized human lung pericyte cell line. Developed using SV40 large T antigen lentivirus, immortalized pericytes exhibited stable SV40T expression, sustained proliferation, and had significantly higher telomerase activity compared to normal human lung pericytes.
    [Laboratory Investigation]

    Abstract

    Modulation of cAMP Metabolism for CFTR Potentiation in Human Airway Epithelial Cells

    Human airway epithelial cells were used to test the efficacy of cyclic AMP modulation by ABCC4 and PDE-4 inhibition through a series of concentration–response studies.
    [Scientific Reports]

    Full Article

    circNDUFB2 Inhibits Non-Small Cell Lung Cancer Progression via Destabilizing IGF2BPs and Activating Anti-Tumor Immunity

    Researchers identified circNDUFB2 to be downregulated in NSCLC tissues, and to negatively correlate with NSCLC malignant features.
    [Nature Communications]

    Full Article

    ACPA Decreases Non-Small Cell Lung Cancer Line Growth through Akt/PI3K and JNK Pathways In Vitro

    Investigators confirmed that CB1 receptor (CB1R) was expressed in NSCLC cells in this study. Arachidonoylcyclopropylamide (ACPA) as a synthetic, CB1R-specific ligand decreased proliferation rate in NSCLC cells by WST-1 analysis and real-time proliferation assay.
    [Cell Death & Disease]

    Full Article

    CXCR4 Uses STAT3-Mediated Slug Expression to Maintain Radioresistance of Non-Small Cell Lung Cancer Cells: Emerges as a Potential Prognostic Biomarker for Lung Cancer

    Researchers inferred that CXCR4 confers resistance to ionizing radiation (IR) in NSCLC cells. Further, on the basis of colony forming ability, they found that drug-resistant A549/GR cells with improved CXCR4 expression exhibited more resistance to IR than A549 cells evidenced along with a reduction in the formation of γ-H2AX foci after IR.
    [Cell Death & Disease]

    Full Article

    Nrf2 Regulates Cell Motility through RhoA–ROCK1 Signaling in Non-Small-Cell Lung Cancer Cells

    Scientists observed that nuclear factor-erythroid 2-related factor 2 (Nrf2) suppression following treatment with brusatol in NSCLC cells with either exogenously introduced kelch-like ECH-associated protein 1 or siNrf2 resulted in the inhibition of cell migration and invasion, with shrinking cell morphology due to decreased focal adhesions via inhibition of the RhoA–ROCK1 pathway.
    [Scientific Reports]

    Full Article

    Studying COVID-19 with ALI culture
    REVIEWS

    Regulation of Immune Responses by the Airway Epithelial Cell Landscape

    The authors discuss how the view of the airway epithelial landscape has evolved with the advent of transcriptomic approaches to cellular phenotyping, with a focus on epithelial interactions with the local neuronal and immune systems.
    [Nature Reviews Immunology]

    Full Article

    INDUSTRY AND POLICY NEWS

    First Patient Enrolls in PRECISIONS Study for Treatment of Idiopathic Pulmonary Fibrosis

    The Pulmonary Fibrosis Foundation announced enrollment of the first patient in PRECISIONS clinical trial. This is the first clinical trial to apply the principles of precision medicine to the treatment of patients with idiopathic pulmonary fibrosis.
    [Pulmonary Fibrosis Foundation]

    Press Release

    Innovent Announces NMPA Acceptance of a Supplemental New Drug Application for TYVYT® (Sintilimab Injection) in Combination with BYVASDA® (Bevacizumab Injection) as First-Line Therapy in Hepatocellular Carcinoma (HCC)

    Innovent Biologics, Inc. announced that the National Medical Products Administration (NMPA) of China has accepted the supplemental New Drug Application for TYVYT® in combination with BYVASDA® as first-line therapy for patients with HCC.
    [Innovent Biologics, Inc.]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells and Global Sustainability

    February 3 – 23, 2021
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    JOB OPPORTUNITIES

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    STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada

    Postdoctoral Fellowship – Stem Cell Biology/Lung Biology

    University of California, San Francisco – San Francisco, California, United States

    Postdoctoral Fellowship – Lung Cancer Research

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow Position – Host-Pathogen Interactions

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Postdoctoral Fellowship – Pro-Metastatic Tumor Microenvironment

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

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