Pulmonary Cell News Volume 10.05 | Feb 11 2021

May 12, 2022

2021-02-11 | PULCN 10.05

Pulmonary Cell News by STEMCELL Technologies

Vol. 10.05 – 11 February, 2021

TOP STORY

USP9X-Mediated
KDM4C Deubiquitination Promotes Lung Cancer Radioresistance by Epigenetically Inducing TGF-β2 Transcription

Investigators provided evidence that genetic or pharmacological inhibition of lysine-specific demethylase 4C (KDM4C) impairs tumorigenesis and radioresistance in lung cancer in vitro and in vivo.
[Cell Death & Differentiation]

Full Article

PUBLICATIONSRanked by the impact factor of the journal

Transcriptomic
Profiling of SARS-CoV-2 Infected Human Cell Lines Identifies HSP90 as Target for COVID-19 Therapy

Scientists report gene expression profiles of three SARS-CoV and SARS-CoV-2 infected human cell lines. SARS-CoV-2 elicited an approximately two-fold higher stimulation of the innate immune response compared to SARS-CoV in the human epithelial cell line Calu-3, including induction of miRNA-155.
[iScience]

Full Article Graphical Abstract

Second-Generation
Lung-on-a-Chip with an Array of Stretchable Alveoli Made with a Biological Membrane

Investigators presented a lung-on-a-chip, based on a biological, stretchable and biodegradable membrane made of collagen and elastin, that emulates an array of tiny alveoli with in vivo-like dimensions.
[Communications Biology]

Full Article

PHAIR: A Biosensor for pH Measurement in Air–Liquid Interface Cell Culture

Researchers made PHAIR—a new pH sensor that used a micro-wire format to measure pH in vitro human airway cell culture.
[Scientific Reports]

Full Article

Role
of CXCL16 in BLM-Induced Epithelial–Mesenchymal Transition in Human A549 Cells

The authors found that C-X-C motif chemokine receptor 16 (CXCL16) and its receptor CXCR6 were upregulated in bleomycin (BLM) induced epithelial–mesenchymal transition in human alveolar type II-like epithelial A549 cells.
[Respiratory Research]

Full Article

LUNG CANCER

Akt Kinase LANCL2 Functions as a Key Driver in EGFR-Mutant Lung Adenocarcinoma Tumorigenesis

Researchers investigated whether lanthionine synthetase C-like protein 2 (LANCL2) played a role in promoting cell proliferation and drug resistance in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma.
[Cell Death & Disease]

Full Article

Upregulation
of LINC01426 Promotes the Progression and Stemness in Lung Adenocarcinoma by Enhancing the Level of SHH Protein to Activate the Hedgehog Pathway

Functionally, silencing of long intergenic non-protein coding RNA 1426 (LINC01426) obviously suppressed the proliferation, migration, epithelial–mesenchymal transition, and stemness of lung adenocarcinoma cells.
[Cell Death & Disease]

Full Article

Urinary
Malate Dehydrogenase 2 Is a New Biomarker for Early Detection of Non‐Small Cell Lung Cancer

Scientists demonstrated that the urinary malate dehydrogenase 2 concentration was higher in early‐stage NSCLC patients than that in controls and might serve as a potential biomarker for the early detection of NSCLC.
[Cancer Science]

Abstract

Human
Umbilical Vein Endothelial Cells-Derived MicroRNA-203-Containing Extracellular Vesicles Alleviate Non-Small-Cell Lung Cancer Progression through Modulating the DTL/p21 Axis

The authors investigated the potential of extracellular vesicles derived from human umbilical vein endothelial cells to transfer miR-203 to affect the progression of NSCLC. miR-203 and p21 were poorly expressed while DTL was highly expressed both in NSCLC tissues and cell lines.
[Cancer Gene Therapy]

Abstract

Tools and products for your COVID-19 research.

REVIEWS

Understanding
the Key Issues in the Treatment of Uncontrolled Persistent Asthma with Type 2 Inflammation

Scientists summarize the current understanding of the biology of type 2 inflammation in asthma, examine its influence on type 2 inflammatory comorbidities, and discuss how type 2 inflammatory biomarkers can be harnessed to further personalise treatments in the age of biologic medicines.
[European Respiratory Journal]

Abstract

INDUSTRY AND POLICY NEWS

Protalix Biotherapeutics Enters into an Exclusive Partnership with Sarcomed USA to Develop Alidornase Alfa for the Treatment of Pulmonary Sarcoidosis and Related Respiratory Diseases via Inhaled Delivery

Protalix BioTherapeutics, Inc. announced an exclusive worldwide license agreement with SarcoMed USA Inc. for alidornase alfa, or PRX–110, for use in the treatment of any human respiratory disease or condition including, but not limited to, sarcoidosis, pulmonary fibrosis, and other related diseases via inhaled delivery.
[Protalix BioTherapeutics (PR Newswire, LLC.)]

Press Release

Therapeutic Solutions International Acquires Stem Cell Therapy That Successfully Completed FDA Double Blind Placebo Controlled Efficacy Study for Lung Disease

Therapeutic Solutions International, Inc. announced acquisition of the JadiCell™, cell therapy, for use in the treatment of acute respiratory distress syndrome and other lung pathologies.
[Therapeutic Solutions International, Inc. (PR Newswire, LLC.)]

Press Release

FEATURED EVENT

USP9X-Mediated
KDM4C Deubiquitination Promotes Lung Cancer Radioresistance by Epigenetically Inducing TGF-β2 Transcription

Transcriptomic
Profiling of SARS-CoV-2 Infected Human Cell Lines Identifies HSP90 as Target for COVID-19 Therapy

Second-Generation
Lung-on-a-Chip with an Array of Stretchable Alveoli Made with a Biological Membrane

PHAIR: A Biosensor for pH Measurement in Air–Liquid Interface Cell Culture

Role
of CXCL16 in BLM-Induced Epithelial–Mesenchymal Transition in Human A549 Cells

Akt Kinase LANCL2 Functions as a Key Driver in EGFR-Mutant Lung Adenocarcinoma Tumorigenesis

Upregulation
of LINC01426 Promotes the Progression and Stemness in Lung Adenocarcinoma by Enhancing the Level of SHH Protein to Activate the Hedgehog Pathway

Urinary
Malate Dehydrogenase 2 Is a New Biomarker for Early Detection of Non‐Small Cell Lung Cancer

Human
Umbilical Vein Endothelial Cells-Derived MicroRNA-203-Containing Extracellular Vesicles Alleviate Non-Small-Cell Lung Cancer Progression through Modulating the DTL/p21 Axis

Understanding
the Key Issues in the Treatment of Uncontrolled Persistent Asthma with Type 2 Inflammation

Protalix Biotherapeutics Enters into an Exclusive Partnership with Sarcomed USA to Develop Alidornase Alfa for the Treatment of Pulmonary Sarcoidosis and Related Respiratory Diseases via Inhaled Delivery

Therapeutic Solutions International Acquires Stem Cell Therapy That Successfully Completed FDA Double Blind Placebo Controlled Efficacy Study for Lung Disease

Lung Development, Injury and Repair

> See All Events

Associate Scientist – Mammalian Cell Biology

Postdoctoral Position – M.
tuberculosis Infection

PhD Student Position – Pulmonary Infections

Postdoctoral Fellow – Cancer Metabolism

Postdoctoral Fellowship – Stem Cell Biology/Lung Biology

> See All Jobs