| Vol. 2.25 – 4 March, 2021 |
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| Researchers describe a strategy for directed differentiation of human pluripotent stem cells (hPSCs) into mature lung and airway epithelial cells obtained through maturation of NKX2.1+ hPSC-derived lung progenitors in a 3D matrix of collagen I in the absence of glycogen synthase kinase 3 inhibition. [Nature Protocols] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In vivo, the role of panaxydol (PX) on lipopolysaccharide (LPS)-induced acute lung injury in mice was tested by determination of LPS-induced pulmonary inflammation, pulmonary edema and ferroptosis. In vitro, BEAS-2B cells were used to investigate the molecular mechanisms by which PX functions via determination of inflammation, ferroptosis and their relationship. [Journal of Translational Medicine] |
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| Scientists provided a basis for the protective effect and mechanism of evodiamine in LPS‐induced inflammation and suggest that it might be potential therapeutics in human pulmonary infections. [Phytotherapy Research] |
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| Tobacco carcinogen transformed human bronchial epithelial lines were characterized for cytosine DNA methylation, transcriptome reprogramming, and the effect of inhibiting EZH2 and G9a on the transformed phenotype. The effects of targeting EZH2 and G9a on lung cancer prevention was assessed in the A/J mouse lung tumor model. [Clinical Epigenetics] |
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| Researchers uncovered that FK228 sensitized human radioresistant SCLC cells to radiation mainly through induction of chromatin decondensation and suppression of DNA damage signaling and repair. [Clinical Epigenetics] |
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| Investigators showed that Maf1 was required for rapamycin to increase radio-sensitivity in A549 lung cancer cells. [Aging] |
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| Lysine-specific histone demethylase 1 (LSD1) demethylated the Septin 6 (SEPT6) promoter to upregulate SEPT6, which activated TGF-β1 pathway, thereby promoting metastasis of NSCLC. [Cancer Gene Therapy] |
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| Down-regulation of long intergenic non-protein coding RNA 01089 (LINC01089) promoted the progression of NSCLC through regulating miR-152-3p/PTEN axis. [Cancer Cell International] |
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| Lotus leaf flavonoids (LLF) were applied to human lung cancer A549 cells and human SCLC cells H446 in vitro to verify the effect of LLF on apoptosis in these cells through the ROS/p38 MAPK pathway. [Biological Research] |
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| The authors summarize the latest advances in the predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC. [Experimental Hematology & Oncology] |
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| The FDA approved Pfizer Inc.’s supplemental New Drug Application for LORBRENA®, expanding the indication to include first-line treatment of people with anaplastic lymphoma kinase (ALK)-positive NSCLC. LORBRENA® is now indicated for adults with metastatic NSCLC whose tumors are ALK-positive as detected by an FDA-approved test. [Pfizer, Inc.] |
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| April 11 – 13, 2021 San Diego, California, United States |
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| University Hospital of Muenster – Münster, Germany |
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| UT Health Science Center at Tyler – Tyler, Texas, United States |
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| The Francis Crick Institute – London, England, United Kingdom |
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| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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