Pulmonary Cell News Volume 10.09 | Mar 11 2021

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    2021-03-11 | PULCN 10.09


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.09 – 11 March, 2021
    TOP STORY

    CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for FGFR1-Amplified Lung Cancer

    Genetic and pharmacological antagonism of PLK1 in combination with FGFR inhibitor therapy synergized to enhance anti-proliferative effects and drove cancer cell death in vitro and in vivo through activation of the γH2AX-CHK-E2F1 axis.
    [Cancer Research]

    Abstract

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    LasR-Deficient Pseudomonas Aeruginosa Variants Increase Airway Epithelial mICAM-1 Expression and Enhance Neutrophilic Lung Inflammation

    Scientists investigated how lasR mutants modulate airway epithelial membrane bound mICAM-1, a surface adhesion molecule, and determined its impact on neutrophilic inflammation in vitro and in vivo.
    [PLoS Pathogens]

    Abstract

    TGF-β-Induced α-SMA Expression is Mediated by C/EBPβ Acetylation in Human Alveolar Epithelial Cells

    The epithelial-to-mesenchymal transition and fibrotic effect of transforming growth factor-beta 1 (TGF-β1) was dependent on acetylated CCAAT/enhancer binding protein β (C/EBPβ)-mediated regulation of alpha-smooth muscle actin (α-SMA) gene activity. C/EBPβ acetylation might play a central role in pulmonary fibrosis.
    [Molecular Medicine]

    Full Article

    METT3-Mediated m6a mRNA Modification of FBXW7 Suppresses Lung Adenocarcinoma

    Investigators revealed that METTL3 positively regulated FBXW7 expression and confirmed the tumor-suppressive role of m6A-modified FBXW7, providing insight into its epigenetic regulatory mechanisms in lung adenocarcinoma initiation and development.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Ferroptosis Inducer Erastin Sensitizes NSCLC Cells to Celastrol through Activation of the ROS‐Mitochondrial Fission‐Mitophagy Axis

    Researchers found that erastin synergized with celastrol to induce cell death at non‐toxic concentrations. The combined treatment with celastrol and erastin significantly increased reactive oxygen species generation, disrupted mitochondrial membrane potential, and promoted mitochondrial fission
    [Molecular Oncology]

    Abstract

    FAM201A Knockdown Inhibits Proliferation and Invasion of Lung Adenocarcinoma Cells by Regulating miR‐7515/GLO1 Axis

    Downregulation of family with sequence similarity 201‐member A (FAM201A) suppressed the cell proliferation, migration and invasion and promoted the cell apoptosis in lung adenocarcinoma (LUAD) cells. FAM201A overexpression showed tumorigenesis effect on LUAD cells. researchers also demonstrated that FAM201A affected LUAD progression via targeting miR‐7515 to promote GLO1 expression.
    [Journal of Cellular Physiology]

    Abstract

    Synergistic Effects of Type I PRMT and PARP Inhibitors against Non-Small Cell Lung Cancer Cells

    The combination of MS023, a type I protein arginine methyltransferases (PRMT) inhibitor, and the PARP inhibitor BMN-673 demonstrated strong synergistic interaction at low nanomolar concentrations in methylthioadenosine phosphorylase-negative NSCLC cell lines A549, SK-LU-1 and HCC4006.
    [Clinical Epigenetics]

    Full Article

    Curcumin Suppresses the Malignancy of Non-Small Cell Lung Cancer by Modulating the circ-PRKCA/miR-384/ITBG1 Pathway

    Curcumin inhibited NSCLC growth through downregulating circ-PRKCA, which regulated ITGB1 expression by adsorbing miR-384.
    [Biomedicine & Pharmacotherapy]

    Full Article

    Circ_0074027 Contributes to Non‐Small Cell Lung Cancer Progression through Positively Modulating RHOA via Sequestering miR-2467-3p

    RNA_0074027 (Circ_0074027) interacted with microRNA-2467-3p (miR-2467-3p), and ras homolog family member A (RHOA) was a target of miR-2467-3p in NSCLC cells. RHOA silencing blocked the malignant potential of NSCLC cells. Circ_0074027 silencing restrained the malignant phenotypes of NSCLC cells largely through up-regulating miR-2467-3p.
    [Journal of Bioenergetics and Biomembranes]

    Abstract


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    REVIEWS

    The Metastasizing Mechanisms of Lung Cancer: Recent Advances and Therapeutic Challenges

    The authors discuss the experimental models of lung cancer and metastasis, mechanisms in SCLC transfer and the challenges about clinical management of lung cancer.
    [Biomedicine & Pharmacotherapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    FDA Grants Fast Track Designation to Spectrum Pharmaceuticals’ Poziotinib

    Spectrum Pharmaceuticals,Inc. announced that the FDA has granted Fast Track designation for poziotinib for the treatment of NSCLC in previously treated patients with HER2 exon 20 mutations. Spectrum plans to submit a new drug application for poziotinib later this year.
    [Spectrum Pharmaceuticals, Inc.]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Tokyo, Japan

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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Lung Carcinogenesis

    Thomas Jefferson University – Philadelphia, Pennsylvania, United States

    Postdoctoral Position – M. tuberculosis Infection

    UT Health Science Center at Tyler – Tyler, Texas, United States

    Postdoctoral Fellow – p53 and Metabolism

    The Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Researcher – Cancer Immunosuppression

    University Hospital of Muenster – Münster, Germany

    Postdoctoral Fellow – Cancer Metabolism

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    > See All Jobs

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