Pulmonary Cell News Volume 10.11 | Mar 25 2021

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    2021-03-25 | PULCN 10.11


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.11 – 25 March, 2021
    TOP STORY

    Genomic, Epigenomic, and Biophysical Cues Controlling the Emergence of the Lung Alveolus

    Scientists showed that the alignment of cell fates, mediated by biophysical and alveolar type 1-derived paracrine signals, drove the extensive tissue remodeling required for postnatal respiration.
    [Science]

    AbstractGraphical Abstract

    Studying COVID-19 with ALI culture
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Variants Reveal Features Critical for Replication in Primary Human Cells

    By integrating viral sequencing data from patient material, virus stocks, and passaging experiments, together with kinetic virus replication data from nonhuman Vero-CCL81 cells and primary differentiated human bronchial epithelial cells (BEpCs), the authors observed several SARS-CoV-2 features that associated with distinct phenotypes.
    [PLOS Biology]

    Full Article

    Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression

    Researchers showed that the levels of kindlin-2 and its binding partner PYCR1, a key enzyme for proline synthesis, were significantly increased in the lung tissues of human patients with pulmonary fibrosis.
    [American Journal of Respiratory Cell and Molecular Biology]

    Abstract

    Long-Term Evolution of the Epithelial Cell Secretome in Preclinical 3D Models of the Human Bronchial Epithelium

    Investigators developed a 3D model of the human bronchial epithelium using Calu-3 cell line and demonstrated its viability and functionality for 21 days without subculturing.
    [Scientific Reports]

    Full Article

    Postchronic Single-Walled Carbon Nanotube Exposure Causes Irreversible Malignant Transformation of Human Bronchial Epithelial Cells through DNA Methylation Changes

    Postchronic single-walled carbon nanotubes (SWCNTs) exposed human lung cell model were established to investigate SWCNT-induced carcinogenesis.
    [ACS Nano]

    AbstractGraphical Abstract

    Circ-HMGA2 (hsa_circ_0027446) Promotes the Metastasis and Epithelial-Mesenchymal Transition of Lung Adenocarcinoma Cells through the miR-1236-3p/ZEB1 Axis

    Through microarray analysis, researchers obtained the circRNA expression profile of lung adenocarcinoma and found that circ-HMGA2, a novel RNA, was highly expressed in lung adenocarcinoma.
    [Cell Death & Disease]

    Full Article

    MZT2A Promotes NSCLC Viability and Invasion by Increasing Akt Phosphorylation via the MOZART2 Domain

    Scientists showed that mitotic spindle organizing protein 2A (MZT2A) exhibited oncogenic activity by activating galectin‐3‐binding protein and Akt in NSCLC.
    [Cancer Science]

    Abstract

    Tissue-Specific Transplantation Antigen P35B Functions as an Oncogene and is Regulated by Microrna-125a-5p in Lung Cancer

    Researchers demonstrated that tissue‑specific transplantation antigen P35B (TSTA3) was regulated by miR‑125a‑5p and functions as an oncogene in lung cancer via promoting the activation of β‑catenin signaling.
    [Oncology Reports]

    Abstract

    miR‑454‑3p Inhibits Non‑Small Cell Lung Cancer Cell Proliferation and Metastasis by Targeting TGFB2

    miR‑454‑3p overexpression led to the suppression of proliferation, migration, and invasion in A549 and NCI‑H1650 cells. The overexpression of miR‑454‑3p in A549 and NCI‑H1650 cells significantly inhibited EMT. TGFB2 was revealed to be a direct target of miR‑454‑3p by using TargetScan database and luciferase reporter assay.
    [Oncology Reports]

    Abstract

    Optimizing in vitro lung models with Dr. Rachael Rayner.
    REVIEWS

    GRP78 in Lung Cancer

    The authors reviewed the functions and mechanisms of glucose-regulating protein 78 (GRP78) in the pathological processes of lung cancer, including tumorigenesis, apoptosis, autophagy, progression, and drug resistance, giving a comprehensive understanding of the function of GRP78 in lung cancer. They also discussed the potential role of GRP78 as a prognostic biomarker and therapeutic target for lung cancer.
    [Journal of Translational Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    ARIKAYCE® (Amikacin Liposome Inhalation Suspension) Approved by Japan’s Ministry of Health, Labour and Welfare for the Treatment of Patients with NTM Lung Disease Caused by MAC Who Did Not Sufficiently Respond to Prior Treatment with MDR

    Insmed Incorporated announced that Japan’s Ministry of Health, Labour and Welfare has approved ARIKAYCE ® for the treatment of patients with nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex who did not sufficiently respond to prior treatment with a multidrug regimen.
    [Insmed, Inc.]

    Press Release

    FEATURED EVENT

    British Society of Developmental Biology & Genetics Society Annual Spring Meeting

    April 19 – 23, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Tissue Systems

    United Therapeutics Corporation – Manchester, New Hampshire, United States

    Postdoctoral Research Fellow – Lung Carcinogenesis

    Thomas Jefferson University – Philadelphia, Pennsylvania, United States

    Director – Pulmonary Biology

    Translate Bio, Inc. – Lexington, Massachusetts, United States

    Postdoctoral Fellow – Lung Injury/Repair

    Brigham and Woman’s Hospital – Boston, Massachusetts, United States

    Senior/Research Associate – Histology

    Translate Bio, Inc. – Lexington, Massachusetts, United States

    > See All Jobs

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