Pulmonary Cell News Volume 10.13 | Apr 8 2021

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    PULCN 10.13 | Apr 8 2021


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.13 – 8 April, 2021
    TOP STORY

    Ferroptosis Response Segregates Small Cell Lung Cancer (SCLC) Neuroendocrine Subtypes

    Scientists identified non-neuroendocrine SCLC to be vulnerable to ferroptosis through subtype-specific lipidome remodeling.
    [Nature Communications]

    Full Article

    Grow Functional Airway Organoids with PneumaCultâ„¢
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Drives JAK1/2-Dependent Local Complement Hyperactivation

    The authors unexpectedly found that the complement system was one of the intracellular pathways most highly induced by SARS-CoV-2 infection in lung epithelial cells.
    [Science Immunology]

    Full Article

    Small Airway Determinants of Airflow Limitation in Chronic Obstructive Pulmonary Disease

    Small airways from patients with COPD showed thickening of epithelial and subepithelial tissue, mucus plugging and reduced collagen density in the airway wall in severe COPD.
    [Thorax]

    Abstract

    Hypoxic and Pharmacological Activation of HIFs Inhibits SARS-CoV-2 Infection of Lung Epithelial Cells

    Scientists demonstrated that hypoxia and the hypoxia inducible factor (HIF) prolyl hydroxylase inhibitor Roxadustat reduced angiotensin-converting enzyme expression and inhibited SARS-CoV-2 entry and replication in lung epithelial cells via a HIF-1α dependent pathway.
    [Cell Reports]

    AbstractFull ArticleGraphical Abstract

    TFAP2A Potentiates Lung Adenocarcinoma Metastasis by a Novel miR-16 Family/TFAP2A/PSG9/TGF-β Signaling Pathway

    Researchers investigated TFAP2A expression profiling, clinical significance, biological function and molecular underpinnings in LUAD.
    [Cell Death & Disease]

    Full Article

    AMPK Activation by ASP4132 Inhibits Non-Small Cell Lung Cancer Cell Growth

    In primary NSCLC cells and established cell lines ASP4132 potently inhibited cell growth, proliferation and cell cycle progression as well as cell migration and invasion.
    [Cell Death & Disease]

    Full Article

    CARD10 Cleavage by MALT1 Restricts Lung Carcinoma Growth In Vivo

    Preventing CARD10 cleavage in the lung tumor A549 cell line increased basal levels of IL-6 and extracellular matrix components in vitro.
    [Oncogenesis]

    Full Article

    MicroRNA-499 Serves as a Sensitizer for Lung Cancer Cells to Radiotherapy by Inhibition of CK2α-Mediated Phosphorylation of p65

    Researchers performed loss and gain of function experiments for the expression of miR-499 in lung cancer cells exposed to irradiation to determine the effect of miR-499 expression on cell viability and apoptosis as well as tumor growth.
    [Molecular Therapy-Oncolytics]

    AbstractFull ArticleGraphical Abstract

    Tubulin Acetylation Enhances Lung Cancer Resistance to Paclitaxel-Induced Cell Death through Mcl-1 Stabilization

    Investigators showed that paclitaxel-resistant H460 lung cancer cells, generated by a stepwise increase in paclitaxel, exhibited markedly increased tubulin acetylation and consequently acquired paclitaxel resistance.
    [Cell Death Discovery]

    Full Article

    LncRNA UCC Promotes Epithelial–Mesenchymal Transition via the miR-143-3p/SOX5 Axis in Non-Small-Cell Lung Cancer

    A dual-luciferase reporter system and RIP assays showed that UCC specifically bound to miR-143-3p and acted as a sponge of miR-143-3p in NSCLC cells.
    [Laboratory Investigation]

    Abstract

    Explore scientific events this April with the Science Events Calendar.
    REVIEWS

    Influenza Virus and SARS-CoV-2: Pathogenesis and Host Responses in the Respiratory Tract

    Scientists discuss what is known about SARS-CoV-2 in the context of the broad knowledge of influenza virus, highlighting the similarities and differences between the respiratory viruses.
    [Nature Reviews Microbiology]

    Abstract

    Fusion Proteins in Lung Cancer: Addressing Diagnostic Problems for Deciding Therapy

    The authors explore current diagnostic problems of gene fusion detection relative to the technologies available, in order to clarify future standardization of analyses which determine therapeutic choices.
    [Expert Review of Anticancer Therapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    BeiGene Provides Update on Phase II Clinical Trial of Zanubrutinib in Patients with COVID-19-Related Pulmonary Distress

    BeiGene, Ltd. announced that the Phase II trial evaluating BRUKINSA® in patients hospitalized with respiratory symptoms of COVID-19, requiring supplemental oxygen without mechanical ventilation, did not meet the co-primary efficacy endpoints of respiratory failure-free survival or reduction in days on oxygen as compared to placebo.
    [BeiGene, Ltd. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    British Society of Developmental Biology & Genetics Society Annual Spring Meeting

    April 19 – 23, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Associate Professor – Xenotransplantation of the Lungs

    Hannover Medical School – Hannover, Germany

    Research Associate – Tissue Systems

    United Therapeutics Corporation – Manchester, New Hampshire, United States

    Postdoctoral Research Fellow – Lung Carcinogenesis

    Thomas Jefferson University – Philadelphia, Pennsylvania, United States

    Director – Pulmonary Biology

    Translate Bio, Inc. – Lexington, Massachusetts, United States

    Postdoctoral Fellow – Lung Injury/Repair

    Brigham and Woman’s Hospital – Boston, Massachusetts, United States

    > See All Jobs

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