| Vol. 10.13 – 8 April, 2021 |
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| Scientists identified non-neuroendocrine SCLC to be vulnerable to ferroptosis through subtype-specific lipidome remodeling. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors unexpectedly found that the complement system was one of the intracellular pathways most highly induced by SARS-CoV-2 infection in lung epithelial cells. [Science Immunology] |
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| Small airways from patients with COPD showed thickening of epithelial and subepithelial tissue, mucus plugging and reduced collagen density in the airway wall in severe COPD. [Thorax] |
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| Scientists demonstrated that hypoxia and the hypoxia inducible factor (HIF) prolyl hydroxylase inhibitor Roxadustat reduced angiotensin-converting enzyme expression and inhibited SARS-CoV-2 entry and replication in lung epithelial cells via a HIF-1α dependent pathway. [Cell Reports] |
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| Researchers investigated TFAP2A expression profiling, clinical significance, biological function and molecular underpinnings in LUAD. [Cell Death & Disease] |
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| In primary NSCLC cells and established cell lines ASP4132 potently inhibited cell growth, proliferation and cell cycle progression as well as cell migration and invasion. [Cell Death & Disease] |
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| Preventing CARD10 cleavage in the lung tumor A549 cell line increased basal levels of IL-6 and extracellular matrix components in vitro. [Oncogenesis] |
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| Researchers performed loss and gain of function experiments for the expression of miR-499 in lung cancer cells exposed to irradiation to determine the effect of miR-499 expression on cell viability and apoptosis as well as tumor growth. [Molecular Therapy-Oncolytics] |
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| Investigators showed that paclitaxel-resistant H460 lung cancer cells, generated by a stepwise increase in paclitaxel, exhibited markedly increased tubulin acetylation and consequently acquired paclitaxel resistance. [Cell Death Discovery] |
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| A dual-luciferase reporter system and RIP assays showed that UCC specifically bound to miR-143-3p and acted as a sponge of miR-143-3p in NSCLC cells. [Laboratory Investigation] |
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| Scientists discuss what is known about SARS-CoV-2 in the context of the broad knowledge of influenza virus, highlighting the similarities and differences between the respiratory viruses. [Nature Reviews Microbiology] |
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| The authors explore current diagnostic problems of gene fusion detection relative to the technologies available, in order to clarify future standardization of analyses which determine therapeutic choices. [Expert Review of Anticancer Therapy] |
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| BeiGene, Ltd. announced that the Phase II trial evaluating BRUKINSA® in patients hospitalized with respiratory symptoms of COVID-19, requiring supplemental oxygen without mechanical ventilation, did not meet the co-primary efficacy endpoints of respiratory failure-free survival or reduction in days on oxygen as compared to placebo. [BeiGene, Ltd. (BusinessWire, Inc.)] |
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| April 19 – 23, 2021 Virtual |
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| Hannover Medical School – Hannover, Germany |
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| United Therapeutics Corporation – Manchester, New Hampshire, United States |
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| Thomas Jefferson University – Philadelphia, Pennsylvania, United States |
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| Translate Bio, Inc. – Lexington, Massachusetts, United States |
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| Brigham and Woman’s Hospital – Boston, Massachusetts, United States |
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