Pulmonary Cell News Volume 10.15 | Apr 22 2021

May 12, 2022

Pulmonary Cell News by STEMCELL Technologies

Vol. 10.15 – 22 April, 2021

TOP STORY

Contextual
Cues from Cancer Cells Govern Cancer-Associated Fibroblast Heterogeneity

Cancer-associated fibroblasts responded to contextual cues from lung adenocarcinoma cells to promote metastasis.
[Cell Reports]

Full Article Graphical Abstract

Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.

PUBLICATIONSRanked by the impact factor of the journal

Isolation
and Characterisation of Lymphatic Endothelial Cells from Lung Tissues Affected by Lymphangioleiomyomatosis

Researchers found that lymphangioleiomyomatosi affected lung tissues (LECs) had significantly higher ability of proliferation and migration compared to control LECs.
[Scientific Reports]

Full Article

Carboxylesterases
and Arylacetamide Deacetylase Comparison in Human A549, H460, and H727 Pulmonary Cells

Scientists investigated the presence, kinetic parameters, and inhibition of carboxylesterases, and arylacetamide deacetylase in A549, H460, and H727 pulmonary cells in both living cells and S9 fractions.
[Life Sciences]

Abstract Graphical Abstract

LUNG CANCER

Chemotherapy-Induced
CDA Expression Renders Resistant Non-small Cell Lung Cancer Cells Sensitive to 5′-Deoxy-5-Fluorocytidine (5′-DFCR)

Investigators identified and exploited chemotherapy-induced metabolic adaptations to target resistant cancer cells.
[Journal of Experimental & Clinical Cancer Research]

Full Article

A
Collagen Glucosyltransferase Drives Lung Adenocarcinoma Progression in Mice

Scientists showed that electrostatic interactions between the lysyl hydroxylase (LH) domain active site and collagen determined the unique telopeptidyl lysyl hydroxylase activity of LH2.
[Communications Biology]

Full Article

Hyperoxia-Activated
Circulating Extracellular Vesicles Induce Lung and Brain Injury in Neonatal Rats

Investigators utilized a neonatal rat model of bronchopulmonary dysplasia to assess if hyperoxia stimulated lung release of circulating extracellular vesicles (EVs) and if these EVs induced lung and brain injury.
[Scientific Reports]

Full Article

Enhanced
Cell Death Effects of MAP Kinase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Increased ROS Levels and GSH Depletion

Researchers investigated the effects of mitogen-activated protein kinase inhibitors on propyl gallate (PG)-treated Calu-6 and A549 lung cancer cells in relation to cell death as well as reactive oxygen species (ROS) and glutathione (GSH) levels.
[Toxicology in Vitro]

Abstract

Purpurin,
a Anthraquinone Induces ROS-Mediated A549 Lung Cancer Cell Apoptosis via Inhibition of PI3K/AKT and Proliferation

Scientists evaluated purpurin, a natural biomedicine and a potential inhibitor in decreasing the growth rate of lung cancer cells by modulating the role of PI3K/AKT signaling-associated proliferation and apoptosis.
[Journal of Pharmacy and Pharmacology]

Full Article

hsa_circ_0058357
Acts as a ceRNA to Promote Non-small Cell Lung Cancer Progression via the Hsa-miR-24-3p/AVL9 Axis

The authors investigated the role of hsa_circ_0058357 on the progression of non‑small cell lung cancer. Cell proliferation, migration and apoptosis were determined using cell counting kit‑8, Transwell and flow cytometry assays, respectively.
[Molecular Medicine Reports]

Abstract

REVIEWS

In Vitro
and In Vivo Analysis of Metabolites Involved in the TCA Cycle and Glutamine Metabolism Associated with Cisplatin Resistance in Human Lung Cancer

Scientists investigated the metabolic differences upon cisplatin treatment in lung cancer in vitro and in vivo.
[Expert Review of Proteomics]

Abstract

Role
of Pirfenidone in TGF-β Pathways and Other Inflammatory Pathways in Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Infection: A Theoretical Perspective

Pirfenidone is a safe drug for patients with hypertension or diabetes and its side effect tolerated well. The drug as a theoretical perspective may be an effective and safe choice for suppressing the inflammatory response during COVID-19.
[Pharmacological Reports]

Full Article

INDUSTRY AND POLICY NEWS

Boehringer Ingelheim and MD Anderson Expand Collaboration to Accelerate Development of KRAS and TRAILR2 Compounds in Lung Cancer

Boehringer Ingelheim and The University of Texas MD Anderson Cancer Center announced the extension and expansion of their joint Virtual Research and Development Center to explore new molecules from Boehringer Ingelheim’s Kirsten rat sarcoma (KRAS) and TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) portfolios for the potential treatment of lung cancer, particularly NSCLC.
[Boehringer Ingelheim and The University of Texas MD Anderson Cancer Center (BUSINESS WIRE)]

Press Release

Novocure Announces FDA IDE Approval and Steering Committee for KEYNOTE-B36 Trial Evaluating Tumor Treating Fields Together with Pembrolizumab in Non-Small Cell Lung Cancer

Novocure announced that the US FDA has approved its investigational device exemption application to initiate the KEYNOTE-B36 trial, conducted in collaboration with Merck & Co., Inc.
[Novocure, Inc.]

Press Release

FEATURED EVENT

Contextual
Cues from Cancer Cells Govern Cancer-Associated Fibroblast Heterogeneity

Isolation
and Characterisation of Lymphatic Endothelial Cells from Lung Tissues Affected by Lymphangioleiomyomatosis

Carboxylesterases
and Arylacetamide Deacetylase Comparison in Human A549, H460, and H727 Pulmonary Cells

Chemotherapy-Induced
CDA Expression Renders Resistant Non-small Cell Lung Cancer Cells Sensitive to 5′-Deoxy-5-Fluorocytidine (5′-DFCR)

A
Collagen Glucosyltransferase Drives Lung Adenocarcinoma Progression in Mice

Hyperoxia-Activated
Circulating Extracellular Vesicles Induce Lung and Brain Injury in Neonatal Rats

Enhanced
Cell Death Effects of MAP Kinase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Increased ROS Levels and GSH Depletion

Purpurin,
a Anthraquinone Induces ROS-Mediated A549 Lung Cancer Cell Apoptosis via Inhibition of PI3K/AKT and Proliferation

hsa_circ_0058357
Acts as a ceRNA to Promote Non-small Cell Lung Cancer Progression via the Hsa-miR-24-3p/AVL9 Axis

In Vitro
and In Vivo Analysis of Metabolites Involved in the TCA Cycle and Glutamine Metabolism Associated with Cisplatin Resistance in Human Lung Cancer

Role
of Pirfenidone in TGF-β Pathways and Other Inflammatory Pathways in Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Infection: A Theoretical Perspective

Boehringer Ingelheim and MD Anderson Expand Collaboration to Accelerate Development of KRAS and TRAILR2 Compounds in Lung Cancer

Novocure Announces FDA IDE Approval and Steering Committee for KEYNOTE-B36 Trial Evaluating Tumor Treating Fields Together with Pembrolizumab in Non-Small Cell Lung Cancer

Stem
Cells, Cell Therapies, and Bioengineering in Lung Biology and Lung Diseases

> See All Events

Postdoctoral Position – Biophysics of Extracellular Vesciles

Associate Professor – Xenotransplantation of the Lungs

Postdoctoral Research Fellow – Lung Carcinogenesis

Research Associate – Tissue Systems

Postdoctoral Fellow – Lung Injury/Repair

>
See All Jobs