Pulmonary Cell News Volume 10.16 | Apr 29 2021

May 12, 2022

Subject

Pulmonary Cell News by STEMCELL Technologies

Vol. 10.16 – 29 April, 2021

TOP STORY

Pazopanib
Ameliorates Acute Lung Injuries via Inhibition of MAP3K2 and MAP3K3

Researchers found that pazopanib ameliorated acute lung injury (ALI) manifestations and reduced mortality in mouse ALI models and reduced edema in human lung transplantation recipients.
[Science Translational Medicine]

Abstract

Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.

PUBLICATIONSRanked by the impact factor of the journal

Selective
Deletion of SHIP-1 in Hematopoietic Cells in Mice Leads to Severe Lung Inflammation Involving ILC2 Cells

Scientists demonstrated that mice lacking src homology 2 domain–containing inositol 5-phosphatase 1 (SHIP-1) selectively in hematopoietic cells developed spontaneous type 2 like inflammation in the lung.
[Scientific Reports]

Full Article

Alveolar
Epithelial TET2 Is Not Involved in the Development of Bleomycin-Induced Pulmonary Fibrosis

To study the role of Tet methylcytosine dioxygenase 2 (TET2) in alveolar epithelial cells during fibrosis, rseearchers determined TET2 protein levels in the lungs of IPF patients and compared TET2 expression in alveolar epithelial cells of idiopathic pulmonary fibrosis patients and controls using publicly available data sets.
[FASEB Journal]

Abstract

Determination
of Tigecycline in Human Lung Epithelial Cells and Polymorphonuclear Neutrophils by LC-MS/MS and Its Application in Cellular Pharmacokinetic Study

Investigators developed and fully validated a liquid chromatography with tandem mass spectrometry (LC‐MS/MS) method for quantification of tigecycline in human lung epithelial cells and polymorphonuclear neutrophils.
[Rapid Communications in Mass Spectrometry]

Abstract

LUNG CANCER

Triptolide
Suppresses the Growth and Metastasis of Non-Small Cell Lung Cancer by Inhibiting β-Catenin-Mediated Epithelial–Mesenchymal Transition

Researchers investigated the effect of triptolide on the migration and invasion of non-small cell lung cancer cell lines.
[Acta Pharmacologica Sinica]

Full Article

m6A
Demethylase FTO Induces NELL2 Expression by Inhibiting E2F1 m6A Modification Leading to Metastasis of Non-Small-Cell Lung Cancer

The authors explored the regulatory role of E2F transcription factor-1 and underlying mechanism in non-small-cell lung cancer development.
[Molecular Therapy-Oncolytics]

Abstract Graphical Abstract

ALK
Inhibition Activates LC3B-Independent, Protective Autophagy in EML4-ALK Positive Lung Cancer Cells

Scientists indicated that ALK inhibition triggered LC3B-independent macroautophagic flux in EML4-ALK⁺ cells to support cancer cell survival and clonogenic growth.
[Scientific Reports]

Full Article

Schisandrin
B Inhibits Epithelial-Mesenchymal Transition and Stemness of Large-Cell Lung Cancer Cells and Tumorigenesis in Xenografts via Inhibiting the NF-κB and p38 MAPK Signaling Pathways

Investigators established cancer stem‑like cells derived from large‑cell lung cancer cells, NCI‑H460 and H661, and revealed that Schisandrin B inhibited the viability of cancer stem‑like cells at concentrations of ≥40 µmol/l.
[Oncology Reports]

Abstract

DNAJC12
Promotes Lung Cancer Growth by Regulating the Activation of β-Catenin

Scientists revealed that the DnaJ heat shock protein family (HSP40) member C12 (DNAJC12) expression levels were significantly upregulated in lung cancer tissues compared with non‑cancer lung tissues.
[International Journal of Molecular Medicine]

Abstract

Optimizing in vitro lung models with Dr. Rachael Rayner.

REVIEWS

Role
of Pirfenidone in TGF-β Pathways and Other Inflammatory Pathways in Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Infection: A Theoretical Perspective

Pirfenidone is an anti-fibrotic drug with an anti-oxidant activity that can prevent lung injury during SARS-CoV-2 infection by blocking the maturation process of transforming growth factor-beta and enhancing the protective role of peroxisome proliferator-activated receptors.
[Pharmacological Reports]

Abstract

Anti-Cancer
& Anti-Metastasis Properties of Bioorganic-Capped Silver Nanoparticles Fabricated from Juniperus chinensis Extract against Lung Cancer Cells

The authors elucidated the cellular and molecular mechanisms of nanoparticles for anti-proliferative and apoptotic effects on human lung cancer cells and compared them with commercial drug cisplatin.
[Amb Express]

Abstract

INDUSTRY AND POLICY NEWS

Vertex Announces European Commission Approval for KAFTRIO^® (ivacaftor/tezacaftor/elexacaftor) in Combination with Ivacaftor to Treat Cystic Fibrosis Patients 12 Years and Older with At Least One F508del Mutation in the CFTR gene

Vertex Pharmaceuticals, Inc. announced that the European Commission has granted approval of the label extension for KAFTRIO^® in a combination regimen with ivacaftor for the treatment of cystic fibrosis in all patients ages 12 years and older who have at least one F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
[Vertex Pharmaceuticals, Inc.]

Press Release

Nirsevimab Demonstrated Protection against Respiratory Syncytial Virus Disease in Healthy Infants in Phase III Trial

Positive topline results from the Phase III MELODY trial showed nirsevimab reduced lower respiratory tract infections requiring medical attention due to respiratory syncytial virus in healthy preterm and term infants.
[Nirsevimab, Inc. (Globenews wire, Inc.)]

Press Release

FEATURED EVENT

Pazopanib
Ameliorates Acute Lung Injuries via Inhibition of MAP3K2 and MAP3K3

Selective
Deletion of SHIP-1 in Hematopoietic Cells in Mice Leads to Severe Lung Inflammation Involving ILC2 Cells

Alveolar
Epithelial TET2 Is Not Involved in the Development of Bleomycin-Induced Pulmonary Fibrosis

Determination
of Tigecycline in Human Lung Epithelial Cells and Polymorphonuclear Neutrophils by LC-MS/MS and Its Application in Cellular Pharmacokinetic Study

Triptolide
Suppresses the Growth and Metastasis of Non-Small Cell Lung Cancer by Inhibiting β-Catenin-Mediated Epithelial–Mesenchymal Transition

m6A
Demethylase FTO Induces NELL2 Expression by Inhibiting E2F1 m6A Modification Leading to Metastasis of Non-Small-Cell Lung Cancer

ALK
Inhibition Activates LC3B-Independent, Protective Autophagy in EML4-ALK Positive Lung Cancer Cells

Schisandrin
B Inhibits Epithelial-Mesenchymal Transition and Stemness of Large-Cell Lung Cancer Cells and Tumorigenesis in Xenografts via Inhibiting the NF-κB and p38 MAPK Signaling Pathways

DNAJC12
Promotes Lung Cancer Growth by Regulating the Activation of β-Catenin

Role
of Pirfenidone in TGF-β Pathways and Other Inflammatory Pathways in Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Infection: A Theoretical Perspective

Anti-Cancer
& Anti-Metastasis Properties of Bioorganic-Capped Silver Nanoparticles Fabricated from Juniperus chinensis Extract against Lung Cancer Cells

Vertex Announces European Commission Approval for KAFTRIO^® (ivacaftor/tezacaftor/elexacaftor) in Combination with Ivacaftor to Treat Cystic Fibrosis Patients 12 Years and Older with At Least One F508del Mutation in the CFTR gene

Nirsevimab Demonstrated Protection against Respiratory Syncytial Virus Disease in Healthy Infants in Phase III Trial

Stem
Cells, Cell Therapies, and Bioengineering in Lung Biology and Lung Diseases

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Research Technician – Virus Interactions in Lungs

Postdoctoral Position – Biophysics of Extracellular Vesciles

Postdoctoral Research Fellow – Lung Carcinogenesis

Research Associate – Tissue Systems

Postdoctoral Fellow – Lung Injury/Repair

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