Pulmonary Cell News Volume 10.17 | May 6 2021

May 12, 2022

Subject

Pulmonary Cell News by STEMCELL Technologies

Vol. 10.17 – 6 May, 2021

TOP STORY

Differential
Chromatin Binding of the Lung Lineage Transcription Factor NKX2-1 Resolves Opposing Murine Alveolar Cell Fates In Vivo

Scientists reported that the cell-type-specific function of NKX2-1 was attributed to its differential chromatin binding that was acquired or retained during development in coordination with partner transcriptional factors.
[Nature Communications]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

Reversed-Engineered
Human Alveolar Lung-On-A-Chip Model

Investigators demonstrated a unique method for reconstitution of the functional human pulmonary alveoli in vitro, which was anticipated to pave the way for investigating relevant physiological and pathological events in the human distal lung.

[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

Potential
Role for EZH2 in Promotion of Asthma through Suppression of miR-34b Transcription by Inhibition of FOXO3

Researchers investigated the molecular mechanism of enhancer of zeste homolog 2 (EZH2) in the development of asthma.
[Laboratory Investigation]

Abstract

Microvesicles
Released from Pneumolysin-Stimulated Lung Epithelial Cells Carry Mitochondrial Cargo and Suppress Neutrophil Oxidative Burst

Scientists aimed to characterize microvesicles shed from pneumolysin-stimulated alveolar epithelial cells and explored their contribution in mediating crosstalk with neutrophils.
[Scientific Reports]

Full Article

LUNG CANCER

Single-Cell
Profiling of Tumor Heterogeneity and the Microenvironment in Advanced Non-Small Cell Lung Cancer

Investigators analyzed 42 tissue biopsy samples from stage III/IV non-small cell lung cancer (NSCLC) patients by single cell RNA sequencing and presented the large scale, single cell resolution profiles of advanced NSCLCs.
[Nature Communications]

Full Article

EGFR-ERK
Induced Activation of GRHL1 Promotes Cell Cycle Progression by Up-Regulating Cell Cycle Related Genes in Lung Cancer

Scientists found that GRHL1 was upregulated in non-small cell lung cancer and correlated with poor survival of patients.
[Cell Death & Disease]

Full Article

Lung
Carcinoid Tumors with Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) Exhibit Pejorative Pathological Features

Carcinoid tumors with proven DIPNECH were associated with negative pathological features and might deserve a dedicated perioperative management.

[Lung Cancer]

Abstract

Regulation
of Amyloid-β Levels by Matrix Metalloproteinase-2/9 (MMP2/9) in the Media of Lung Cancer Cells

Scientists identified regulators of intact amyloid-β40/42 levels in A549 and H1299 lung cancer cell media.
[Scientific Reports]

Full Article

Nanoparticle-Mediated
Tumor Cell Expression of mIL-12 via Systemic Gene Delivery Treats Syngeneic Models of Murine Lung Cancers

Investigators described an effective approach through systemic injection of engineered polymer/DNA nanoparticles that mediated tumor-specific expression of a therapeutic gene, under the control of the cancer-selective progression elevated gene 3 promoter, to treat tumors in the lungs of diseased mice.
[Scientific Reports]

Full Article

Acquired Resistance Mechanism of
EGFR Kinase Domain Duplication to EGFR TKIs in Non-Small Cell Lung Cancer

Researchers investigated the acquired resistance mechanism of epidermal growth factor receptor (EGFR) kinase domain duplication against EGFR-tyrosine kinase inhibitors.
[Cancer Research and Treatment]

Abstract

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REVIEWS

Is
There a Role for Percutaneous Ablation for Early Stage Lung Cancer? What Is the Evidence?

The authors review data published with different thermal ablation (TA) techniques: radiofrequency ablation, microwave ablation and cryoablation. They also review the comparison that has been made between TA and stereotactic radiotherapy.
[Current Oncology Reports]

Abstract

INDUSTRY AND POLICY NEWS

The FDA Expands Collaboration with CN Bio to Investigate Lung-On-A-Chip Model for Inhaled Drug Evaluation Applications

CN Bio, Inc., announced the US FDA has extended their research collaboration, for a further three years.
[CN Bio, Inc. (Business Wire, Inc.)]

Press Release

ImmunoMet Therapeutics Granted Fast Track Designation by US FDA for IM156 in Idiopathic Pulmonary Fibrosis

ImmunoMet Therapeutics, Inc., announced that the US FDA has granted Fast Track designation for its lead compound IM156, an investigational Protein Complex 1 inhibitor, being evaluated for idiopathic pulmonary fibrosis.
[ImmunoMet Therapeutics, Inc. (Business Wire, Inc.)]

Press Release

FEATURED EVENT

Differential
Chromatin Binding of the Lung Lineage Transcription Factor NKX2-1 Resolves Opposing Murine Alveolar Cell Fates In Vivo

Reversed-Engineered
Human Alveolar Lung-On-A-Chip Model

Potential
Role for EZH2 in Promotion of Asthma through Suppression of miR-34b Transcription by Inhibition of FOXO3

Microvesicles
Released from Pneumolysin-Stimulated Lung Epithelial Cells Carry Mitochondrial Cargo and Suppress Neutrophil Oxidative Burst

Single-Cell
Profiling of Tumor Heterogeneity and the Microenvironment in Advanced Non-Small Cell Lung Cancer

EGFR-ERK
Induced Activation of GRHL1 Promotes Cell Cycle Progression by Up-Regulating Cell Cycle Related Genes in Lung Cancer

Lung
Carcinoid Tumors with Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) Exhibit Pejorative Pathological Features

Regulation
of Amyloid-β Levels by Matrix Metalloproteinase-2/9 (MMP2/9) in the Media of Lung Cancer Cells

Nanoparticle-Mediated
Tumor Cell Expression of mIL-12 via Systemic Gene Delivery Treats Syngeneic Models of Murine Lung Cancers

Acquired Resistance Mechanism of
EGFR Kinase Domain Duplication to EGFR TKIs in Non-Small Cell Lung Cancer

Is
There a Role for Percutaneous Ablation for Early Stage Lung Cancer? What Is the Evidence?

The FDA Expands Collaboration with CN Bio to Investigate Lung-On-A-Chip Model for Inhaled Drug Evaluation Applications

ImmunoMet Therapeutics Granted Fast Track Designation by US FDA for IM156 in Idiopathic Pulmonary Fibrosis

Stem
Cells, Cell Therapies, and Bioengineering in Lung Biology and Lung Diseases

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