Pulmonary Cell News Volume 10.18 | May 13 2021

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    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.18 – 13 May, 2021
    TOP STORY

    Th17 Cells Contribute to Combination MEK Inhibitor and Anti-PD-L1 Therapy Resistance in KRAS/p53 Mutant Lung Cancers

    Researchers showed that MEK inhibition enhanced PD-L1 expression while PD-L1 blockade upregulated MAPK signaling in mutant KRAS lung tumors.
    [Nature Communications]

    Full Article

    Virtual Conference Exhibition: Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    The Long Non-Coding RNA PFI Protects against Pulmonary Fibrosis by Interacting with Splicing Regulator SRSF1

    Scientists investigated the role of long non-coding RNAs (lncRNAs) in lung fibrosis. Scientists used a qRT-PCR assay to identify dysregulated lncRNAs in the lungs of mice with experimental, bleomycin-induced pulmonary fibrosis, and a series of molecular assays to assess the role of the novel lncRNA NONMMUT060091, designated as pulmonary fibrosis inhibitor, which was significantly downregulated in lung fibrosis.
    [Cell Death & Differentiation]

    Full Article

    Resetting Proteostasis with ISRIB Promotes Epithelial Differentiation to Attenuate Pulmonary Fibrosis

    Investigators showed that administration of ISRIB, a small molecule that restores protein translation by EIF2B during activation of the integrated stress response, accelerated the differentiation of alveolar type 2 into alveolar type 1 cells.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Alveolar Epithelial Cell Fate Is Maintained in a Spatially Restricted Manner to Promote Lung Regeneration after Acute Injury

    Researchers investigated the role of Fgfr2 signaling in alveolar epithelial type 2 cells across the lifespan and during adult regeneration after influenza infection.
    [Cell Reports]

    Abstract

    A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma

    Scientists advanced the model system and identified a non-genetic mechanism of resistance that drive recovery and regrowth in a subset of cells.
    [eLife]

    Abstract

    PLK1/Vimentin Signaling Facilitates Immune Escape by Recruiting Smad2/3 to PD-L1 Promoter in Metastatic Lung Adenocarcinoma

    Researchers showed that vimentin phosphorylated by PLK1, triggered TGF-β-signaling, which consequently led to metastasis and PD-L1 expression for immune suppression in lung adenocarcinoma.
    [Cell Death & Differentiation]

    Full Article

    RNA m6A Reader YTHDF2 Facilitates Lung Adenocarcinoma Cell Proliferation and Metastasis by Targeting the AXIN1/Wnt/β-Catenin Signaling

    Investigators found that YTHDF2 was significantly upregulated in lung adenocarcinoma (LUAD) compared with paracancerous normal tissues, and YTHDF2 knockdown drastically inhibited, while its overexpression promoted, cell growth, colony formation and migration of LUAD cells in vitro.
    [Cell Death & Disease]

    Full Article

    Distinct Mutational Backgrounds and Clonal Architectures Implicated Prognostic Discrepancies in Small-Cell Carcinomas of the Esophagus and Lung

    By performing whole-exome sequencing of 48 small-cell carcinoma of the esophagus (SCCE) and 64 small-cell lung cancer (SCLC) tumor samples, respectively researchers have shown that the number of driver mutations in SCCE was significantly lower than in SCLC
    [Cell Death & Disease]

    Full Article

    Relationship between Long Non-Coding RNA PCAT-1 Expression and Gefitinib Resistance in Non-Small-Cell Lung Cancer Cells

    Investigators elucidated the expression and role of long non-coding RNA – PCAT – 1, a potential biomarker for drug resistance and a therapeutic target for NSCLC, in gefitinib resistance in NSCLC cells.
    [Respiratory Research]

    Full Article

    An informative, visually-compelling wallchart detailing the organization and biology of the respiratory system. Request your copy.
    REVIEWS

    COVID-19 and the Multidisciplinary Care of Patients with Lung Cancer: An Evidence-Based Review and Commentary

    Cross-cutting themes and challenges were identified using qualitative methods for patients, healthcare professionals and service delivery, with a clear need for continued studies to guide evidence-based decision-making.
    [British Journal of Cancer]

    Full Article

    Role of Innate Immune System in Environmental Lung Diseases

    Environmental pollutants, such as particulate matter, ozone, and other products of combustion, both stimulate and disrupt the function of the innate immune system of the lung, leading to the potential for pathologic consequences.
    [Current Allergy and Asthma Reports]

    Full Article

    INDUSTRY AND POLICY NEWS

    Merus Announces Collaborations in Israel, Italy and Spain to Increase Screening and Identification of Cancer Patients with NRG1 Fusion Tumors and to Raise Awareness of the Phase I/II eNRGy Clinical Trial

    Merus, Inc. announced new collaborations in Israel, Italy and Spain to expand molecular screening opportunities for patients with cancers that may have neuregulin 1 fusions and to raise awareness of the Merus eNRGy clinical trial of its bispecific antibody zenocutuzumab.
    [Merus, Inc. (Business Wire, Inc.)]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Tokyo, Japan

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Lung Stem Cells and Alveolar Repair

    University of Illinois at Chicago – Chicago, Illinois, United States

    Postdoctoral Fellow – Asthma

    Brigham and Women’s Hospital – Boston, US Minor Outlying Islands

    Postdoctoral Research Fellow – Fibrotic Lung Disease

    University of Exeter – Exeter, United Kingdom

    Assistant Professor – Lung Cancer

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Research Technician – Virus Interactions in Lungs

    Helmholtz Zentrum München – Neuherberg (bei München), Germany

    > See All Jobs

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