Pulmonary Cell News Volume 10.19 | May 20 2021

May 12, 2022

Subject

Pulmonary Cell News by STEMCELL Technologies

Vol. 10.19 – 20 May, 2021

TOP STORY

Club
Cell-Specific Role of Programmed Cell Death 5 in Pulmonary Fibrosis

Scientists demonstrated the club cell-specific role of programmed cell death 5 as a mediator of lung fibrosis and potential therapeutic target for idiopathic pulmonary fibrosis.
[Nature Communications]

Full Article

Learn about optimization of in vitro lung models in this webinar by Dr. Rachael Rayner

PUBLICATIONSRanked by the impact factor of the journal

AP-3–Dependent
Targeting of Flippase ATP8A1 to Lamellar Bodies Suppresses Activation of YAP in Alveolar Epithelial Type 2 Cells

Researchers identified AP-3–mediated targeting of flippase ATP8A1 to lamellar bodies, lysosome-related organelles that stored pulmonary surfactant for secretion from alveolar epithelial cells.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Cereblon Contributes to the Development of Pulmonary Fibrosis via Inactivation of Adenosine Monophosphate-Activated Protein Kinase α1

Investigators evaluated the role of cereblon in bleomycin-induced pulmonary fibrosis in mice and in transforming growth factor-beta 1-induced differentiation of human lung fibroblasts.
[Experimental & Molecular Medicine]

Full Article

Categorization
of Lung Mesenchymal Cells in Development and Fibrosis

Researchers completed scRNA-seq analysis of mesenchymal cells from the embryonic, post-natal, adult and aged fibrotic lungs of mice and humans.
[iScience]

Abstract Graphical Abstract

Neuraminidase
and SIGLEC15 Modulate the Host Defense against Pulmonary Aspergillosis

Scientists provided evidence that host neuraminidase (NA) activity and sialic acid recognition were important for anti-Aspergillus defense. NA inhibitors might predispose individuals with severe influenza to invasive aspergillosis.
[Cell Reports Medicine]

Full Article

The
Arachidonic Acid Metabolite 11,12-Epoxyeicosatrienoic Acid Alleviates Pulmonary Fibrosis

Liquid chromatography with tandem mass spectrometry was used to analyze epoxyeicosatrienoic acids in the lung tissues of patients with idiopathic pulmonary fibrosis and controls, and the function of 11,12-EET was evaluated in in vitro and in vivo in pulmonary fibrosis models.
[Environmental & Molecular Medicine]

Full Article

LUNG CANCER

Weighting
Tumor-Specific TCR Repertoires as a Classifier to Stratify the Immunotherapy Delivery in Non–Small Cell Lung Cancers

Researchers developed a previously unidentified index, the T cell receptor (TCR)-based immunotherapy response index, that estimated the degree of overlap of the TCR repertoire between tumor-infiltrating lymphocytes and circulating PD-1⁺CD8⁺T cells.
[Science Advances]

Full Article

A
Tyrosine Kinase Inhibitor-Induced Interferon Response Positively Associates with Clinical Response in EGFR-Mutant Lung Cancer

RNAseq was performed on EGFR mutant cell lines treated in vitro with osimertinib and on tumor biopsies of eight EGFR mutant lung cancer patients before and after two weeks of tyrosine kinase inhibitor treatment.
[npj Precision Oncology]

Full Article

Cephalomannine
Inhibits Hypoxia-Induced Cellular Function via the Suppression of APEX1/HIF-1α Interaction in Lung Cancer

Researchers explored the mechanisms underlying cell responses to hypoxia and modulation of apurinic/apyrimidinic endonuclease-1, which regulated hypoxic-induced factor-1α and downstream pathways.
[Cell Death & Disease]

Full Article

A
miR-375/YAP Axis Regulates Neuroendocrine Differentiation and Tumorigenesis in Lung Carcinoid Cells

The authors identified and elucidated the function of a miR-375/yes-associated protein axis in lung carcinoid cells.
[Scientific Reports]

Full Article

ULK1
Inhibition Overcomes Compromised Antigen Presentation and Restores Antitumor Immunity in LKB1-Mutant Lung Cancer

Investigators found that LKB1 deficiency correlated with elevated tumor mutational burden in non-small cell lung cancers from nonsmokers and genetically engineered mouse models, despite the frequent association between high-TMB and anti-PD-1 treatment efficacy.
[Nature Cancer]

Full Article

Register for a recorded organoid panel discussion moderated by Dr. James Wells

REVIEWS

Wnt
Signaling in Lung Development, Regeneration, and Disease Progression

The authors note uncharted directions in the field that may illuminate important biology. The discoveries made collectively advance our understanding of Wnt signaling in lung biology and have the potential to inform therapeutic advancements for lung diseases.
[Communications Biology]

Full Article

Progress and Application of Circulating Tumor Cells in Non-Small Cell Lung Cancer

Scientists discuss the technologies for detection and enrichment of circulating tumor cells, as well as clinical applications involving circulating tumor cells.
[Molecular Therapy-Oncolytics]

Abstract

INDUSTRY AND POLICY NEWS

Novocure Announces FDA Approval of IDE Supplement for Phase III Pivotal LUNAR Trial of Tumor Treating Fields in Non-Small Cell Lung Cancer

Novocure, Inc. announced the US FDA has approved the company’s Investigational Device Exemption supplement, reducing the enrollment requirement for its LUNAR trial to 276 patients with 12 months follow-up. LUNAR is a Phase III pivotal trial testing the effectiveness of Tumor Treating Fields in combination with immune checkpoint inhibitors or docetaxel versus immune checkpoint inhibitors or docetaxel alone for patients with stage IV NSCLC who progressed during or after platinum-based therapy.
[
Novocure, Inc. (Business Wire, Inc.)]

Press Release

ReAlta Life Sciences Expands Phase I Clinical Trial of RLS-0071 to Include Three Multiple-Ascending Dose Cohorts and an Additional Single Ascending Dose Cohort

ReAlta Life Sciences, Inc., announced that it has received a no objection letter from Health Canada to an amendment of the Company’s Phase I clinical trial of RLS-0071 in healthy volunteers. The study design has been modified to add three multiple ascending dose cohorts and an additional single ascending high dose cohort to the trial.
[ReAlta Life Sciences, Inc.]

Press Release

FEATURED EVENT

Club
Cell-Specific Role of Programmed Cell Death 5 in Pulmonary Fibrosis

AP-3–Dependent
Targeting of Flippase ATP8A1 to Lamellar Bodies Suppresses Activation of YAP in Alveolar Epithelial Type 2 Cells

Cereblon Contributes to the Development of Pulmonary Fibrosis via Inactivation of Adenosine Monophosphate-Activated Protein Kinase α1

Categorization
of Lung Mesenchymal Cells in Development and Fibrosis

Neuraminidase
and SIGLEC15 Modulate the Host Defense against Pulmonary Aspergillosis

The
Arachidonic Acid Metabolite 11,12-Epoxyeicosatrienoic Acid Alleviates Pulmonary Fibrosis

Weighting
Tumor-Specific TCR Repertoires as a Classifier to Stratify the Immunotherapy Delivery in Non–Small Cell Lung Cancers

A
Tyrosine Kinase Inhibitor-Induced Interferon Response Positively Associates with Clinical Response in EGFR-Mutant Lung Cancer

Cephalomannine
Inhibits Hypoxia-Induced Cellular Function via the Suppression of APEX1/HIF-1α Interaction in Lung Cancer

A
miR-375/YAP Axis Regulates Neuroendocrine Differentiation and Tumorigenesis in Lung Carcinoid Cells

ULK1
Inhibition Overcomes Compromised Antigen Presentation and Restores Antitumor Immunity in LKB1-Mutant Lung Cancer

Wnt
Signaling in Lung Development, Regeneration, and Disease Progression

Progress and Application of Circulating Tumor Cells in Non-Small Cell Lung Cancer

Novocure Announces FDA Approval of IDE Supplement for Phase III Pivotal LUNAR Trial of Tumor Treating Fields in Non-Small Cell Lung Cancer

ReAlta Life Sciences Expands Phase I Clinical Trial of RLS-0071 to Include Three Multiple-Ascending Dose Cohorts and an Additional Single Ascending Dose Cohort

EMBO Workshop: Cancer Immunometabolism

> See All Events

Postdoctoral Scholar – Lung or Pancreatic Cancer

Postdoctoral Position – Lung Stem Cells and Alveolar Repair

Postdoctoral Fellow – Asthma

Assistant Professor – Lung Cancer

Research Technician – Virus Interactions in Lungs

>
See All Jobs