Pulmonary Cell News Volume 10.20 | May 27 2021

May 12, 2022

Subject

Pulmonary Cell News by STEMCELL Technologies

Vol. 10.20 – 27 May, 2021

TOP STORY

Peripheral
and Lung Resident Memory T Cell Responses against SARS-CoV-2

Researchers highlighted a balanced anti-inflammatory antiviral response associated with a better outcome and persisting T_RM cells as important for future protection against SARS-CoV-2 infection.
[Nature Communications]

Full Article

Explore scientific events this June with the Science Events Calendar.

PUBLICATIONSRanked by the impact factor of the journal

Synergistic
Cycles of Protease Activity and Inflammation via PPARγ Degradation in Chronic Obstructive Pulmonary Disease

Scientists evaluated the effect of neutrophil elastase on lipopolysaccharide – induced interleukin 8 production and determined the molecular mechanism in human bronchial epithelial cells.
[Experimental and Molecular Medicine]

Full Article

Effect
of Slit/Robo Signaling on Regeneration in Lung Emphysema

Researchers evaluated the effect of Slit2 on the proliferation and migration of mouse lung epithelial cells and its role in regeneration in an emphysema lung mouse model.
[Experimental & Molecular Medicine]

Full Article

Prematurity
Alters the Progenitor Cell Program of the Upper Respiratory Tract of Neonates

Investigators developed a minimally invasive methodology for isolation of neonatal basal cells from nasopharyngeal aspirates and performed functional analysis in organotypic cultures to address this issue.
[Scientific Reports]

Full Article

Viral
Fibrotic Scoring and Drug Screen Based on MAPK Activity Uncovers EGFR as a Key Regulator of COVID-19 Fibrosis

Researchers clustered 277 cell lines and revealed distinct COVID-19 transcriptomic signatures of the cells with similar phenotypes that defines their suitability for COVID-19 research.
[Scientific Reports]

Full Article

LUNG CANCER

A
Novel CXCR4 Antagonist Counteracts Paradoxical Generation of Cisplatin-Induced Pro-metastatic Niches in Lung Cancer

Scientists investigated the interconnected pathways underlying the promotion of cisplatin-induced metastases.
[Molecular Therapy]

Abstract Graphical Abstract

PD-L1
Recruits Phospholipase C and Enhances Tumorigenicity of Lung Tumors Harboring Mutant Forms of EGFR

Researchers showed that the underlying mechanisms involved the recruitment of phospholipase C-γ1 (PLC-γ1) to a cytoplasmic motif of PD-L1, which enhances PLC-γ1 activation by EGFR.
[Cell Reports]

Full Article Graphical Abstract

Suppression
of m6A mRNA Modification by DNA Hypermethylated ALKBH5 Aggravates the Oncological Behavior of KRAS Mutation/LKB1 Loss Lung Cancer

ALKBH5 gain- or loss-of function could effectively reverse LKB1 regulated cell proliferation, colony formation, and migration of KRAS-mutated lung cancer cells.
[Cell Death & Disease]

Full Article

KEAP1
Deficiency Drives Glucose Dependency and Sensitizes Lung Cancer Cells and Tumors to GLUT Inhibition

Investigators showed that KEAP1 deficiency promotes glucose dependency in lung cancer cells, and KEAP1-mutant/deficient lung cancer cells were more vulnerable to glucose deprivation than their WT counterparts.
[iScience]

Abstract Graphical Abstract

SLC45A4
Promotes Glycolysis and Prevents AMPK/ULK1-Induced Autophagy in TP53 Mutant Pancreatic Ductal Adenocarcinoma

Scientists explored the TCGA datasets to identify oncogenes in TP53 mutant pancreatic ductal adenocarcinoma. MTS, colony formation and Edu assays were performed to study the function of SLC45A4 in vitro.
[Journal of Gene Medicine]

Abstract

Watch this webinar to learn the advantages of using primary human nasal epithelial cells to study Cystic Fibrosis.

REVIEWS

COVID-19
and Pulmonary Fibrosis: A Potential Role for Lung Epithelial Cells and Fibroblasts

The disease ranges in severity from asymptomatic through to severe acute respiratory distress requiring intensive care treatment and mechanical ventilation, which can lead to respiratory failure and death.
[Immunological Reviews]

Full Article

Cross-Correlation
of Virome–Bacteriome–Host–Metabolome to Study Respiratory Health

Scientists describe how the composition and function of airway and gut virome and bacteriome may contribute to pathogen establishment and propagation in airway districts and how the virome–bacteriome communities may react to respiratory diseases.
[Trends in Microbiology]

Full Article

INDUSTRY AND POLICY NEWS

Opdivo (Nivolumab) Plus Yervoy (Ipilimumab) with Two Cycles of Chemotherapy Demonstrates Durable Overall Survival vs. Chemotherapy at Two Years in First-Line Non-small Cell Lung Cancer in Phase III CheckMate -9LA Trial

Bristol Myers Squibb, Inc. announced that Opdivo (nivolumab) plus Yervoy (ipilimumab) with two cycles of chemotherapy showed a durable survival benefit compared to four cycles of chemotherapy alone after two years of follow-up in previously untreated patients with advanced non-small cell lung cancer.
[Bristol Myers Squibb, Inc.]

Press Release

FEATURED EVENT

Peripheral
and Lung Resident Memory T Cell Responses against SARS-CoV-2

Synergistic
Cycles of Protease Activity and Inflammation via PPARγ Degradation in Chronic Obstructive Pulmonary Disease

Effect
of Slit/Robo Signaling on Regeneration in Lung Emphysema

Prematurity
Alters the Progenitor Cell Program of the Upper Respiratory Tract of Neonates

Viral
Fibrotic Scoring and Drug Screen Based on MAPK Activity Uncovers EGFR as a Key Regulator of COVID-19 Fibrosis

A
Novel CXCR4 Antagonist Counteracts Paradoxical Generation of Cisplatin-Induced Pro-metastatic Niches in Lung Cancer

PD-L1
Recruits Phospholipase C and Enhances Tumorigenicity of Lung Tumors Harboring Mutant Forms of EGFR

Suppression
of m6A mRNA Modification by DNA Hypermethylated ALKBH5 Aggravates the Oncological Behavior of KRAS Mutation/LKB1 Loss Lung Cancer

KEAP1
Deficiency Drives Glucose Dependency and Sensitizes Lung Cancer Cells and Tumors to GLUT Inhibition

SLC45A4
Promotes Glycolysis and Prevents AMPK/ULK1-Induced Autophagy in TP53 Mutant Pancreatic Ductal Adenocarcinoma

COVID-19
and Pulmonary Fibrosis: A Potential Role for Lung Epithelial Cells and Fibroblasts

Cross-Correlation
of Virome–Bacteriome–Host–Metabolome to Study Respiratory Health

Opdivo (Nivolumab) Plus Yervoy (Ipilimumab) with Two Cycles of Chemotherapy Demonstrates Durable Overall Survival vs. Chemotherapy at Two Years in First-Line Non-small Cell Lung Cancer in Phase III CheckMate -9LA Trial

EMBO Workshop: Cancer Immunometabolism

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Research Associate – Senescence in Cancer

Postdoctoral Scholar – Lung or Pancreatic Cancer

Postdoctoral Position – Lung Stem Cells and Alveolar Repair

Postdoctoral Fellow – Asthma

Assistant Professor – Lung Cancer

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