Pulmonary Cell News Volume 10.21 | Jun 3 2021

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    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.21  – 3 June, 2021
    TOP STORY

    KLHL38 Involvement in Non-Small Cell Lung Cancer Progression via Activation of the Akt Signaling Pathway

    Scientists clarified the role of KLHL38 in non-small cell lung cancer (NSCLC). KLHL38 expression was evaluated in tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry and real-time PCR, and its association with clinicopathological parameters was analyzed.
    [Cell Death & Disease]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Oleoylethanolamide Induces Eosinophilic Airway Inflammation in Bronchial Asthma

    To investigate the effect of oleoylethanolamide, the expression of proinflammatory cytokines was measured by RT-qPCR and ELISA in airway epithelial cells.
    [Experimental and Molecular Medicine]

    Full Article

    BORCS6 Is Involved in the Enlargement of Lung Lamellar Bodies in Lrrk2 Knockout Mice

    Scientists found that the enlargement of lamellar bodies was recapitulated in A549 cells upon knockout of leucine-rich repeat kinase 2 (LRRK2) or by treating cells with LRRK2 inhibitors.
    [Human Molecular Genetics]

    Abstract

    hsa_circ_0008234 Inhibits the Progression of Lung Adenocarcinoma by Sponging miR-574-5p

    The function of circ_0008234 in lung adenocarcinoma (LUAC) remains unknown. Through the Gene Expression Omnibus database, circ_0008234 was first found to be downregulated in LUAC tissues.
    [Cell Death Discovery]

    Full Article

    C1q/TNF-Related Protein-9 Ameliorates Hypoxia-Induced Pulmonary Hypertension by Regulating Secretion of Endothelin-1 and Nitric Oxide Mediated by AMPK in Rats

    Researchers investigated whether C1q/tumor necrosis factor-related protein-9 , a newly identified cardiovascular agent, had protective roles in the development of hypoxia-induced pulmonary hypertension.
    [Scientific Reports]

    Full Article

    Genetic Variants of CHEK1, PRIM2 and CDK6 in the Mitotic Phase-Related Pathway Are Associated with Non-Small Cell Lung Cancer Survival

    Scientists investigated associations between 31,032 single nucleotide polymorphisms (SNPs) in 368 mitotic phase-related pathway genes and overall survival (OS) of patients with non-small cell lung cancer.
    [International Journal of Cancer]

    Abstract

    Evaluation of Stable LifeAct-mRuby2- and LAMP1-NeonGreen Expressing A549 Cell Lines for Investigation of Aspergillus fumigatus Interaction with Pulmonary Cells

    Investigators generated A549 cell lines stably expressing fluorescently labeled actin (LifeAct-mRuby2) and late endosomal protein (LAMP1-NeonGreen) following an evaluation of cell-pathogen interactions in live and fixed cells.
    [International Journal of Molecular Sciences]

    Full Article

    Baicalin Alleviates Chronic Obstructive Pulmonary Disease through Regulation of HSP72-Mediated JNK Pathway

    Lung function and inflammatory cell infiltration were determined and the production of Muc5AC, TNF-α, IL-6, IL-8 in the bronchoalveolar lavage fluid was assayed by ELISA. The effect of HSP72 and JNK on chronic obstructive pulmonary disease following treatment with baicalin was assessed both in vivo and in vitro by conducting loss- and gain- function experiments.
    [Molecular Medicine]

    Abstract

    Circular RNA circ_0010235 Sponges miR-338-3p to Play Oncogenic Role in Proliferation, Migration and Invasion of Non-Small Cell Lung Cancer Cells through Modulating KIF2A

    Researchers investigated the role and mechanism of circ_0010235 in non-small-cell lung cancer proliferation, migration and invasion.
    [Annals of Medicine]

    Full Article

    LncRNASGMS1-AS1 Regulates Lung Adenocarcinoma Cell Proliferation, Migration, Invasion, and EMT Progression via miR-106a-5p/MYLI9 Axis

    To verify the relationship between SGMS1-AS1, miR-106a-5p, and MYLIP, scientists overexpressed miR-106a-5p inhibitor or MYLIP in lung adenocarcinoma cells after decreasing SGMS1-AS1 and repeated the above assays.
    [Thoracic Cancer]

    Full Article

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    REVIEWS

    Mutated Circulating Tumor DNA as a Liquid Biopsy in Lung Cancer Detection and Treatment

    The authors discuss future perspectives of early-cancer detection and clonal hematopoiesis filtering strategies, with possible inclusion of microbiome-driven liquid biopsy.
    [Molecular Oncology]

    Abstract

    Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer

    Scientists review the biological role of protein kinase C (PKC) isozymes in non-small cell lung cancer through extensive analysis of cell-line-based studies to better understand the rationale for PKC inhibition.
    [International Journal of Molecular Sciences]

    Abstract

    INDUSTRY AND POLICY NEWS

    Rubedo Life Sciences Establishes Collaboration with Cedars-Sinai Medical Center to Advance Idiopathic Pulmonary Fibrosis Program

    Rubedo Life Sciences, Inc. a drug discovery company announced a collaboration with Cedars-Sinai Medical Center in Los Angeles, to advance its idiopathic pulmonary fibrosis program and establish collaborative studies.
    [Rubedo Life Sciences, Inc. (Business Wire, Inc.)]

    Press Release

    FDA Approves Rybrevant for Advanced NSCLC with EGFR Mutations

    The FDA granted accelerated approval to amivantamab-vmjw for the treatment of adults with locally advanced or metastatic non-small cell lung cancer with epidermal growth factor receptor exon 20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy.
    [Clinical Oncology News]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Cell Size and Growth Regulation

    June 21 – 24, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Post-doctoral Fellow – Lung Diseases

    University of Pennsylvania and Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States

    Research Associate – Senescence in Cancer

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Scholar – Lung or Pancreatic Cancer

    University of California San Francisco – San Francisco, California, United States

    Postdoctoral Position – Lung Stem Cells and Alveolar Repair

    University of Illinois at Chicago – Chicago, Illinois, United States

    Postdoctoral Fellow – Asthma

    Brigham and Women’s Hospital – Boston, US Minor Outlying Islands

    > See All Jobs

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