Pulmonary Cell News Volume 10.22 | Jun 10 2021

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    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.22 – 10 June, 2021
    TOP STORY

    Metformin Inhibition of Mitochondrial ATP and DNA Synthesis Abrogates NLRP3 Inflammasome Activation and Pulmonary Inflammation

    Researchers showed that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1β production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide- and SARS-CoV-2-induced Acute respiratory distress syndrome.
    [Immunity]

    Full ArticleGraphical Abstract

    Five tips for returning to the lab after time off
    PUBLICATIONSRanked by the impact factor of the journal

    Mesenchymal Growth Hormone Receptor Deficiency Leads to Failure of Alveolar Progenitor Cell Function and Severe Pulmonary Fibrosis

    The authors identified growth hormone receptor is mainly expressed in mesenchymal cells, and its expression is substantially decreased in idiopathic pulmonary fibrosis lungs.
    [Science Advances]

    Full Article

    m6A Modification Regulates Lung Fibroblast-to-Myofibroblast Transition through Modulating KCNH6 mRNA Translation

    Researchers revealed that m6A modification was up-regulated in bleomycin induced pulmonary fibrosis mice model, FMT-derived myofibroblasts and idiopathic pulmonary fibrosis patient lung samples.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Inhibition of miR-1298-5p Attenuates Sepsis Lung Injury by Targeting SOCS6

    miR-1298-5p and suppressor of cytokine signaling 6 (SOCS6) were silenced or overexpressed in human bronchial epithelial cells. PKH-67 Dye was used to trace exosome endocytosis.
    [Molecular and Cellular Biochemistry]

    Abstract

    LUNG CANCER

    MPDZ as a Novel Epigenetic Silenced Tumor Suppressor Inhibits Growth and Progression of Lung Cancer through the Hippo-YAP Pathway

    The tumor suppressing effects of MPDZ were determined in vitro and in vivo. The target molecules and signaling pathway that mediated the function of MPDZ were also identified.
    [Oncogene]

    Full Article

    A Size-Shrinkable Matrix Metallopeptidase-2-Sensitive Delivery Nanosystem Improves the Penetration of Human Programmed Death-Ligand 1 siRNA into Lung-Tumor Spheroids

    To decrease programmed death-ligand 1 (PD-L1) expression and increase the penetration efficacy of solid tumors, scientists synthesized a novel tumor-microenvironment-sensitive delivery polymer by conjugating hyaluronic acid to polyethyleneimine, with a matrix metalloproteinase-2 -sensitive peptide acting as the linker, for use in delivery of PD-L1–siRNA.
    [Drug Delivery]

    Full Article

    FOXH1 Promotes Lung Cancer Progression by Activating the Wnt/β-Catenin Signaling Pathway

    A549 and PC9 cells were transfected with short hairpin RNA targeting FOXH1 mRNA. The Cell Counting Kit-8, colony formation, soft agar, wound healing, transwell invasion and flow cytometry assays were performed to evaluate proliferation, migration and invasion of lung cancer cells.
    [Cancer Cell International]

    Full Article

    PB01 Suppresses Radio-Resistance by Regulating ATR Signaling in Human Non-Small-Cell Lung Cancer Cells

    Scientists reported the antitumor effects and mechanism of a novel benzothiazole derivative 4-methoxy-cyclohexane carboxylic acid -amide (PB01) in radiation-resistant human non-small-cell lung cancer cells.
    [Scientific Reports]

    Full Article

    Hyperbaric Oxygen Suppressed Tumor Progression through the Improvement of Tumor Hypoxia and Induction of Tumor Apoptosis in A549-Cell-Transferred Lung Cancer

    Reserachers investigated the effects of hyperbaric oxygen treatment (HBOT) on solid tumors, such as lung cancer. Non-small cell human lung carcinoma A549-cell-transferred severe combined immunodeficiency mice were selected as an in vivo model to detect the potential mechanism of HBOT in lung tumors.
    [Scientific Reports]

    Full Article

    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    REVIEWS

    Interstitial Lung Disease in Connective Tissue Disease: A Common Lesion with Heterogeneous Mechanisms and Treatment Considerations

    In this review, the authors focus on examining the pathogenesis of Connective tissue disease related interstitial lung disease with respect to genetics, environmental factors, and immunological factors.
    [Frontiers in Immunology]

    Full Article

    INDUSTRY AND POLICY NEWS

    IMFINZI® Demonstrated Unprecedented Survival in Unresectable Stage III Lung Cancer with 43% of Patients Surviving Five Years

    Updated results from the positive PACIFIC Phase III trial showed AstraZeneca’s IMFINZI® demonstrated a sustained, clinically meaningful overall survival and progression-free survival (PFS) benefit at five years in patients with unresectable Stage III non-small cell lung cancer who had not progressed following concurrent chemoradiation therapy.
    [AstraZeneca, Inc. (BusinessWire, Inc.)]

    Press Release

    MigVax’s Subunit Oral COVID-19 Vaccine Preclinical Trial Demonstrates Effectivity as a Booster

    MigVax Ltd., announced promising results from preclinical tests that demonstrated the effectivity of its MigVax-101 subunit oral vaccine as a booster for previously vaccinated persons.
    [MigVax Ltd. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells and Regenerative Medicine

    January 12 – 14, 2022
    Shanghai, China

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer Biology and Signaling

    Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Post-Doctoral Fellow – Lung Diseases

    University of Pennsylvania and Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States

    Research Associate – Senescence in Cancer

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Scholar – Lung or Pancreatic Cancer

    University of California San Francisco – San Francisco, California, United States

    Postdoctoral Position – Lung Stem Cells and Alveolar Repair

    University of Illinois at Chicago – Chicago, Illinois, United States

    > See All Jobs

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