Pulmonary Cell News Volume 10.23 | Jun 17 2021

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    2021-06-17 | PULCN 10.23


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.23 – 17 June, 2021
    TOP STORY

    PGC-1α Mediates a Metabolic Host Defense Response in Human Airway Epithelium during Rhinovirus Infections

    Researchers observed that early human rhinoviruses (HRV)-C15 infection induced a transitory barrier-protective metabolic state characterized by glycolysis that ultimately became exhausted as the infection progressed and led to cellular damage.
    [Nature Communications]

    Full Article

    Studying COVID-19 with ALI culture
    PUBLICATIONSRanked by the impact factor of the journal

    Airway Basal Stem Cells Reutilize the Embryonic Proliferation Regulator, Tgfβ-Id2 Axis, for Tissue Regeneration

    Using temporal single-cell transcriptomics of developing murine airway progenitors and genetic validation experiments, scientists found that TGF-β signaling decelerated cell cycle by inhibiting Id2 and contributed to slow-cycling basal cell specification during development.
    [Developmental Cell]

    AbstractGraphical Abstract

    Streptococcus pneumoniae Binds to Host GAPDH on Dying Lung Epithelial Cells Worsening Secondary Infection Following Influenza

    Using isogenic mutants of Streptococcus pneumoniae, investigators showed that Pneumococcal surface protein A-glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-mediated binding to lung cells increased pneumococcal localization in the lower airway, and this was enhanced as a result of pneumolysin exposure or co-infection with influenza A virus.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Single-Cell RNA Sequencing Identify SDCBP in ACE2-Positive Bronchial Epithelial Cells Negatively Correlates with COVID-19 Severity

    Since angiotensin-converting enzyme 2 (ACE2)-positive cells were hosts for COVID-19, researchers focussed on this cell type to explore the underlying mechanisms of COVID-19.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Remodeling of Bronchial Epithelium Caused by Asthmatic Inflammation Affects Its Response to Rhinovirus Infection

    Investigators analyzed gene expression response in in vitro differentiated bronchial epithelium exposed to cytokines and next infected with human rhinoviruses 16.
    [Scientific Reports]

    Full Article

    Tissue-Resident Macrophages Provide a Pro-Tumorigenic Niche to Early NSCLC Cells

    To explore the diversity of the macrophage compartment in human non-small cell lung carcinoma (NSCLC) lesions, researchers performed single-cell RNA sequencing of tumor-associated leukocytes.
    [Nature]

    Abstract

    Dissecting the Multi-Omics Atlas of the Exosomes Released by Human Lung Adenocarcinoma Stem-Like Cells

    Scientists presented a detailed transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells.
    [NPJ Genomic Medicine]

    Full Article

    MicroRNA-326 Attenuates Immune Escape and Prevents Metastasis in Lung Adenocarcinoma by Targeting PD-L1 and B7-H3

    Investigators verified that microRNA-326 (miR-326) repressed the gene expression of immune checkpoint molecules PD-L1 and B7-H3 in lung adenocarcinoma. They detected that the expression of miR-326 in LUAD tissue was negatively correlated with PD-L1/B7-H3.
    [Cell Death Discovery]

    Full Article

    GPC3 Affects the Prognosis of Lung Adenocarcinoma and Lung Squamous Cell Carcinoma

    Scientists comprehensively evaluated the expression of Glypican 3 (GPC3) in non-small cell lung cancer (NSCLC) and developed a risk-score model for predicting the prognosis of NSCLC.
    [BMC Pulmonary Medicine]

    Full Article

    Explore Antibodies for Epithelial Cell Markers
    REVIEWS

    Epidermal Growth Factor Receptor Expression and Resistance Patterns to Targeted Therapy in Non-Small Cell Lung Cancer: A Review

    The authors critically analyze the mechanisms of epidermal growth factor receptor expression in non-small cell lung cancer (NSCLC), its relevance to currently approved targeted treatment options, and the complex nature of secondary mutations and intrinsic and acquired resistance patterns in NSCLC.
    [Cells]

    Full Article

    INDUSTRY AND POLICY NEWS

    CF Foundation Launches New Collaboration with Deep Science Ventures to Overcome Challenges to Developing Genetic Therapies for CF

    CF Foundation announced a new collaboration with venture creator Deep Science Ventures, focused on uncovering and designing new technologies with the potential to overcome challenges to developing genetic therapies for cystic fibrosis.
    [CF Foundation]

    Press Release

    Praedicare, Inc. Receives Grant to Evaluate Potential New Drug Regimens for Tuberculosis

    Praedicare, Inc., announced that it has been awarded a two-year, $2.8 million grant by the Bill & Melinda Gates Foundation to evaluate novel Tuberculosis (TB) drug regimens using Praedicare’s in vitro hollow fiber model of TB in identifying potential new drug regimens that shorten treatment times for the disease.
    [Praedicare, Inc. (BusinessWire, Inc.)]

    Press Release

    PulmoSIM Therapeutics Granted Orphan Drug Designation for PT001 by the FDA to Treat Pulmonary Arterial Hypertension

    PulmoSIM Therapeutics announced that the US FDA has granted orphan drug designation for asset PT001 for the treatment of pulmonary arterial hypertension.
    [PulmoSIM Therapeutics, Inc. (BusinessWire, Inc.]

    Press Release

    FEATURED EVENT

    Biology of Acute Respiratory Infection

    February 27 – March 4, 2022
    Ventura, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – In-Situ Gene Therapy

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Cancer Biology and Signaling

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Post-Doctoral Fellow – Lung Diseases

    University of Pennsylvania and Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States

    Research Associate – Senescence in Cancer

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Scholar – Lung or Pancreatic Cancer

    University of California San Francisco – San Francisco, California, United States

    > See All Jobs

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