Pulmonary Cell News Volume 10.26 | Jul 15 2021

    By
    Justin.choi
    -
    0
    35







    2021-15-07 | PULCN 10.26


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.26 – 15 July, 2021
    TOP STORY

    Chronic Lung Diseases Are Associated with Gene Expression Programs Favoring SARS-CoV-2 Entry and Severity

    Researchers analyzed the transcriptomes of 611,398 single cells isolated from healthy and chronic lung disease lungs to identify molecular characteristics of lung cells that might account for worse COVID-19 outcomes in patients with chronic lung diseases.
    [Nature Communications]

    Full Article

    Free Wallchart: Dynamic Modeling in Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    Yap/Taz Inhibit Goblet Cell Fate to Maintain Lung Epithelial Homeostasis

    Through in vivo lineage tracing and in vitro molecular experiments, scientists revealed that reduced YAP/TAZ activity promoted intrinsic goblet transdifferentiation of secretory airway epithelial cells.
    [Cell Reports]

    Full Article

    An Epigenetic Switch Regulates the Ontogeny of AXL Positive/EGFR-TKI Resistant Cells by Modulating miR-335 Expression

    Researchers demonstrated that AXL-positive cells were already present as a sub-population of cancer cells in Erlotinib-naïve tumors and tumor-derived cell lines, and that the expression of AXL was regulated through a stochastic mechanism centered on the epigenetic regulation of miR-335.
    [eLife]

    Abstract

    Vitamin D3 Decreases TNF-α-Induced Inflammation in Lung Epithelial Cells through a Reduction in Mitochondrial Fission and Mitophagy

    Scientists examined the effects and mechanisms of action of vitamin D3 on the expression of intercellular adhesion molecule-1 in vitro and in vivo with or without tumor necrosis factor α treatment.
    [Cell Biology and Toxicology]

    Full Article

    Network and Co-Expression Analysis of Airway Smooth Muscle Cell Transcriptome Delineates Potential Gene Signatures in Asthma

    The gene network for the asthmatic and non-asthmatic group was constructed by prioritizing differentially expressed genes and transcription factors. Researchers identified differentially connected or co-expressed genes in each group.
    [Scientific Reports]

    Full Article

    Single-Cell icroRNA Sequencing Method Comparison and Application to Cell Lines and Circulating Lung Tumor Cells

    Scientists evaluated 19 protocols for single cell small RNA sequencing on MCF7 cells spiked with 1 pg of 1,006 miRNAs.
    [Nature Communications]

    Full Article

    Combined FGFR and Akt Pathway Inhibition Abrogates Growth of FGFR1 Overexpressing EGFR-TKI-Resistant NSCLC Cells

    Researchers identified increased fibroblast growth factor receptor 1 (FGFR1) expression and Akt activation across erlotinib, gefitinib, and osimertinib EGFR-tyrosine kinase inhibitor (TKI)-resistant cell line models.
    [npj Precision Oncology]

    Full Article

    miR-519d-3p Suppresses Tumorigenicity and Metastasis by Inhibiting Bcl-W and HIF-1α in NSCLC

    Scientists investigated the correlation between Bcl-w expression and hypoxia in tumor malignancy of non-small cell lung cancer.
    [Molecular Therapy-Oncolytics]

    AbstractGraphical Abstract

    PTEN Loss Promotes Oncogenic Function of STMN1 via PI3K/AKT Pathway in Lung Cancer

    Researchers found that Stathmin (STMN1) was overexpressed in lung cancer tissues and associated with worse survival rates of lung cancer patients.
    [Scientific Reports]

    Full Article

    HLA-DR Cancer Cells Expression Correlates with T Cell Infiltration and Is Enriched in Lung Adenocarcinoma with Indolent Behavior

    Scientists identified cellular subpopulations of epithelial cancer cells and their microenvironment and validated their results by multiplex immunofluorescence applied to a tissue microarray of long and short-predicted survival lung adenocarcinoma.
    [Scientific Reports]

    Full Article

    Downregulation of NKG2DLs by TGF-β in Human Lung Cancer Cells

    Investigators examined the expression of NKG2DLs, PD-L1 and PD-L2 in lung cancer cells after treatment of TGF-β and a TGF-β inhibitor, Galunisertib.
    [BMC Immunology]

    Full Article

    Dr. Sylvia Boj discusses how organoids are revolutionizing drug screening for cystic fibrosis in this webinar
    REVIEWS

    Recent Developments in the Treatment of Small Cell Lung Cancer

    Scientists describe the progress that has been made in systemic treatment by repurposing existing drugs and the addition of targeted treatment.
    [European Respiratory Review]

    Full Article

    INDUSTRY AND POLICY NEWS

    Arch Biopartners Receives Government of Canada Funding to Support Phase II Therapeutic Trial of Metablok for COVID-19

    Arch Biopartners Inc. announced that the Government of Canada has awarded a contribution of up to $6.7 million from the department of Innovation, Science and Economic Development to support the Phase II development of Metablok, the Company’s therapeutic drug candidate to prevent organ inflammation and injury in patients hospitalized with COVID-19.
    [Arch Biopartners Inc.]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Chair – Respiratory Medicine

    Imperial College London – London, United Kingdom

    Postdoctoral Research Fellow – Viral and Bacterial Lung Infections

    Johns Hopkins University – Baltimore, Maryland, United States

    Postdoctoral Position – Lung Immunology

    Stanford School of Medicine – Palo Alto, California, United States

    Postdoctoral Fellow – In-Situ Gene Therapy

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Cancer Biology and Signaling

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Brought to you by