Pulmonary Cell News Volume 10.27 | Jul 22 2021

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    2021-07-22 | PULCN 10.27


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.27 – 22 July, 2021
    TOP STORY

    Transcriptional Programs of Neoantigen-Specific TIL in Anti-PD-1-Treated Lung Cancers

    Scientists identified mutation-associated neoantigens (MANA)-specific T cell clones using the MANA functional expansion of specific T cells assay3 in neoadjuvant anti-PD-1-treated NSCLC.
    [Nature]

    Full Article


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    PUBLICATIONSRanked by the impact factor of the journal

    S100A9 in Adult Asthmatic Patients: A Biomarker for Neutrophilic Asthma

    The S100 calcium-binding protein A9 (S100A9) levels in sera/culture supernatant of peripheral blood neutrophils and M0 macrophages from asthmatic patients were measured and compared to those of healthy controls.
    [Experimental & Molecular Medicine]

    Full Article

    High-Throughput Human Primary Cell-Based Airway Model for Evaluating Influenza, Coronavirus, or Other Respiratory Viruses In Vitro

    Scientists integrated human primary airway epithelial cells into a custom-engineered 96-device platform in which tissues were cultured in an array of microchannel-based culture chambers at an air–liquid interface, in a configuration compatible with high resolution in-situ imaging and real-time sensing.
    [Scientific Reports]

    Full Article

    Glucocorticoid Receptor Triggers a Reversible Drug-Tolerant Dormancy State with Acquired Therapeutic Vulnerabilities in Lung Cancer

    Pharmacological glucocorticoid receptor activation is frequently used to alleviate therapy-related side-effects. Researchers studied the mechanisms of glucocorticoid response, focusing on lung cancer.
    [Nature Communications]

    Full Article

    Lin28 Paralogs Regulate Lung Branching Morphogenesis

    Scientists found that the Lin28 paralogs, which regulated post-transcriptional processing of both mRNAs and microRNAs, predominantly controlled mRNAs during the initial phases of lung organogenesis.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Circulating Tumor Cell Copy-Number Heterogeneity in ALK-Rearranged Non-Small-Cell Lung Cancer Resistant to ALK Inhibitors

    Researchers provided in-depth investigation of copy number alteration heterogeneity in phenotypically characterized circulating tumor cells at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors in ALK-positive NSCLC.
    [npj Precision Oncology]

    Full Article

    Tempol Differently Affects Cellular Redox Changes and Antioxidant Enzymes in Various Lung-Related Cells

    Scientists investigated changes in cellular reactive oxygen speciesand glutathione levels and in antioxidant enzymes, in Tempol-treated Calu-6 and A549 lung cancer cells, normal lung WI-38 VA-13 cells, and primary pulmonary fibroblasts.
    [Scientific Reports]

    Full Article

    Pyronaridine Induces Apoptosis in Non-Small Cell Lung Cancer Cells by Upregulating DR5 Expression and Inhibiting EGFR

    The authors determined the efficacy of pyronaridine in four different NSCLC cell lines and explored its mechanism in H1975.
    [Chemical Biology & Drug Design]

    Abstract

    CircRIP2 Promotes NSCLC Progression by Sponging for miR-671-5p to Regulate FOXM1 Expression

    Scientists used NSCLC tissues, as well as cell lines to elucidate the expression and location of circRIP2 in NSCLC. They also established the circRIP2 overexpression cells A549-circRIP2 and repression cells HCC827-shcircRIP2 for further functional and mechanism studies.
    [Histology and Histopathology]

    Abstract

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    REVIEWS

    Understanding Idiopathic Pulmonary Fibrosis – Clinical Features, Molecular Mechanism and Therapies

    The authors highlight the advances that have been made in the field of idiopathic pulmonary fibrosis and focus on its pathobiology.
    [Experimental Gerontology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Agilent PD-L1 IHC 22C3 pharmDx Expands CE-IVD Mark in Non-small Cell Lung Cancer (NSCLC)

    Agilent Technologies, Inc. announced that the company’s PD-L1 IHC 22C3 pharmDx assay is now labeled for expanded use in patients with NSCLC in the European Union.
    [Agilent Technologies Inc.]

    Press Release

    FEATURED EVENT

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    September 1 – 3, 2021
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    JOB OPPORTUNITIES

    Research Assistant II – Lung Cancers

    Baylor College of Medicine – Houston, Texas, United States

    Chair – Respiratory Medicine

    Imperial College London – London, United Kingdom

    Postdoctoral Research Fellow – Viral and Bacterial Lung Infections

    Johns Hopkins University – Baltimore, Maryland, United States

    Postdoctoral Position – Lung Immunology

    Stanford School of Medicine – Palo Alto, California, United States

    Postdoctoral Fellow – Cancer Biology and Signaling

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

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