Pulmonary Cell News Volume 10.28 | Jul 29 2021

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    2021-07-29 | PULCN 10.28


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.28 – 29 July, 2021
    TOP STORY

    Pulmonary Fibrosis Distal Airway Epithelia Are Dynamically and Structurally Dysfunctional

    Scientists demonstrated that healthy and idiopathic pulmonary fibrosis (IPF) airway epithelia were biophysically distinct, identifying pathologic activation of the ERBB-YAP axis as a specific and modifiable driver of prolongation of the unjammed-to-jammed transition in IPF epithelia.
    [Nature Communications]

    Full Article

    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    Plasma Extracellular Vesicle Delivery of miR-210-3p by Targeting ATG7 to Promote Sepsis-Induced Acute Lung Injury by Regulating Autophagy and Activating Inflammation

    Researchers elucidated the role of plasma extracellular vesicles in delivering miR-210-3p in sepsis-induced acute lung injury.
    [Experimental & Molecular Medicine]

    Full Article

    Somatic Cell Hemoglobin Modulates Nitrogen Oxide Metabolism in the Human Airway Epithelium

    Primary human airway epithelial cells, cultured at air–liquid interface, were obtained by clinical airway brushings or from explanted lungs. Human airway hemoglobin mRNA data were from publicly available databases; or from RT-PCR.
    [Scientific Reports]

    Abstract

    Molecular Analysis of Pseudomonas aeruginosa Strains Isolated from Cystic Fibrosis Patients

    Scientists applied a multiple-locus variable-number tandem-repeat analysis for an efficient genotyping of clinical P. aeruginosa strains isolated from cystic fibrosis patients and compared results with a TRS-PCR typing.
    [Scientific Reports]

    Full Article

    miR-4293 Upregulates lncRNA WFDC21P by Suppressing mRNA-Decapping Enzyme 2 to Promote Lung Carcinoma Proliferation

    Investigators demonstrated that miR-4293 expression was markedly enhanced in lung carcinoma tissue and cells and miR-4293 promoted tumor cell proliferation and metastasis but suppressed apoptosis.
    [Cell Death & Disease]

    Full Article

    Dynamic BH3 Profiling Identifies Active BH3 Mimetic Combinations in Non-Small Cell Lung Cancer

    Scientists assessed priming of primary patient NSCLC tumor cells on drugs from a clinically relevant oncology combination screen.
    [Cell Death & Disease]

    Full Article

    Exosomal miR-1260b Derived from Non-Small Cell Lung Cancer Promotes Tumor Metastasis through the Inhibition of HIPK2

    Researchers investigated the role of exosomal miR-1260b derived from non-small cell lung cancer in tumor progression.
    [Cell Death & Disease]

    Full Article

    miR-526b-3p Inhibits Lung Cancer Cisplatin-Resistance and Metastasis by Inhibiting STAT3-Promoted PD-L1

    Scientists found that miR-526b-3p expression declined while programmed cell death protein ligand 1 (PD-L1) was elevated in cisplatin-resistant lung cancer compared to that in cisplatin-sensitive lung cancer by analyzing clinical samples.
    [Cell Death & Disease]

    Full Article

    Assessment of the Feasibility of Frozen Sections for the Detection of Spread through Air Spaces (STAS) in Pulmonary Adenocarcinoma

    Researchers evaluated the reliability of spread through air spaces (STAS) assessment on frozen sections compared to permanent sections, as well as the associations among STAS, tumor grade, and recurrence-free survival after sublobar resection.
    [Modern Pathology]

    Abstract

    Combination of Rapamycin and SAHA Enhanced Radiosensitization by Inducing Autophagy and Acetylation in NSCLC

    Scientists investigated the effects of autophagy-inducing agent, rapamycin, combined with the histone deacetylase inhibitor, suberoylanilide hydroxamic acid, on the radiosensitivity of A549 and SK-MES-1 cells, and examined the combination effects on DNA damage repair, and determined the level of autophagy and acetylation in A549 cells.
    [Aging]

    Abstract

    Cisplatin-Induced Hydroxyl Radicals Mediate Pro-Survival Autophagy in Human Lung Cancer H460 Cells

    The role of autophagy in cisplatin resistance was indicated by a decreased cell viability and increased apoptosis in lung cancer H460 cells pre-incubated with wortmannin, an autophagy inhibitor, prior to treatment with 50 µM cisplatin for 24 hours.
    [Biological Research]

    Full Article

    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Targeting EGFR Exon 20 Insertions in Non–small Cell Lung Cancer: Recent Advances and Clinical Updates

    The authors describe the molecular and clinicopathologic features of EGFR ins20 mutations and summarize recent data on emerging therapies for patients with this subtype of EGFR-mutant NSCLC.
    [Cancer Discovery]

    Abstract

    Potential of Helper-Dependent Adenoviral Vectors in CRISPR-Cas9-Mediated Lung Gene Therapy

    Scientists discuss the status of the application of CRISPR/Cas9 in cystic fibrosis gene therapy, the existing challenges in the field, as well as new hurdles introduced by the presence of CRISPR/Cas9 in the lungs.
    [Cell & Bioscience]

    Full Article

    INDUSTRY AND POLICY NEWS

    PulmoSIM Therapeutics Announces Strategic Partnership with Top Respiratory Hospitals to Initiate Clinical Development of PT001 to Treat Pulmonary Arterial Hypertension

    PulmoSIM Therapeutics announced that it has entered into a strategic partnership with the investigators from National Jewish Health and Brown University for the clinical development of PT001, a drug that targets multiple responsible pathways in PAH to provide curative treatment. The FDA recently granted orphan drug designation for PT001 for the treatment of PAH.
    [PulmoSIM Therapeutics, Inc. (BusinessWire, Inc)]

    Press Release

    FEATURED EVENT

    Till & McCulloch Meeting 2021

    November 15 – 17, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Pancreatic, Colon and Lung Cancers.

    Westwood Bioscience, Inc. – Los Angeles, California, United States

    Research Assistant II – Lung Cancers

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Research Fellow – Viral and Bacterial Lung Infections

    Johns Hopkins University – Baltimore, Maryland, United States

    Postdoctoral Position – Lung Immunology

    Stanford School of Medicine – Palo Alto, California, United States

    Postdoctoral Fellow – Cancer Biology and Signaling

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    > See All Jobs

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