Pulmonary Cell News Volume 10.29 | Aug 05 2021

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    2021-08-05 | PULCN 10.29


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.29 – 5 August, 2021
    TOP STORY

    A Proteogenomic Portrait of Lung Squamous Cell Carcinoma

    Investigators characterized the proteogenomic landscape of lung squamous cell carcinoma (LSCC), providing a deeper exposition of LSCC biology with potential therapeutic implications.
    [Cell]

    Full ArticleGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    TGFβ2 and TGFβ3 Isoforms Drive Fibrotic Disease Pathogenesis

    Researchers showed that the latent forms of TGFβ2 and TGFβ3 could be activated by integrin-independent mechanisms and have lower activation thresholds compared to TGFβ1. Unlike TGFB1, TGFB2 and TGFB3 expression was increased in human lung and liver fibrotic tissues compared to healthy control tissues.
    [Science Translational Medicine]

    Abstract

    Constitutive Transgenic Alpha-Klotho Overexpression Enhances Resilience to and Recovery from Murine Acute Lung Injury

    A549 lung epithelial cells transfected with Klotho cDNA or vector were exposed to cigarette smoke; lactate dehydrogenase and double-strand DNA breaks were measured.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    Poly-L-Arginine Promotes Asthma Angiogenesis through Induction of FGFBP1 in Airway Epithelial Cells via Activation of the mTORC1-STAT3 Pathway

    Scientists demonstrated that fibroblast growth factor-binding protein 1 was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine, a mimic of major basic protein.
    [Cell Death & Disease]

    Full Article

    Epidermal Growth Factor Strongly Affects Epithelial Na+ Transport and Barrier Function in Fetal Alveolar Cells, with Minor Sex-Specific Effects

    Researchers analyzed sex-specific fetal distal lung epithelial cells exposed to epidermal growth factor and related ligands with Ussing chambers, RT-qPCR and Western blots.
    [Scientific Reports]

    Full Article

    AKT3-Mediated IWS1 Phosphorylation Promotes the Proliferation of EGFR-Mutant Lung Adenocarcinomas through Cell Cycle-Regulated U2AF2 RNA Splicing

    Scientists showed that exon 2 inclusion in the U2AF2 mRNA was a cell cycle-dependent process that was regulated by LEDGF/SRSF1 splicing complexes, whose assembly was controlled by the IWS1 phosphorylation-dependent deposition of histone H3K36me3 marks in the body of target genes.
    [Nature Communications]

    Full Article

    The Integrated Stress Response Is Tumorigenic and Constitutes a Therapeutic Liability in KRAS-Driven Lung Cancer

    Researchers demonstrated that integrated stress response was pivotal in lung adenocarcinoma development, the most common histological type of lung cancer and a leading cause of cancer death worldwide.
    [Nature Communications]

    Full Article

    RASSF9 Promotes NSCLC Cell Proliferation by Activating the MEK/ERK Axis

    Investigators examined the potential roles of RAS-associated domain family 9 in non-small cell lung cancer and the underlying mechanisms.
    [Cell Death Discovery]

    Full Article

    ASCL1, NKX2-1, and PROX1 Co-Regulate Subtype-Specific Genes in Small Cell Lung Cancer

    The authors integrated chromatin landscape and transcriptome analyses of patient-derived small cell lung cancer (SCLC) preclinical models to identify super-enhancers and their associated genes in the ASCL1-, NEUROD1-, and POU2F3-high SCLC subtypes.
    [iScience]

    AbstractGraphical Abstract

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    REVIEWS

    Adenoviral Vector Vaccine Platforms in the SARS-CoV-2 Pandemic

    Investigators detail adenoviral vector COVID-19 vaccines currently in human clinical trials and provide an overview of the new technologies employed in their design.
    [NPJ Vaccines]

    Full Article

    Mapping Lung Squamous Cell Carcinoma Pathogenesis through In Vitro and In Vivo Models

    Scientists discuss how molecular profiling of premalignant lesions and invasive lung squamous cell carcinoma (LUSC) has contributed to the refinement of in vitro and in vivo models, and in turn, how these systems have increased our understanding of LUSC biology and therapeutic vulnerabilities.
    [Communications Biology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Relief Announces Receipt of US FDA Orphan Drug Designation for the Use of RLF-100 (Aviptadil) in the Treatment of Sarcoidosis

    Relief Therapeutics, AG. reported that, via its newly acquired subsidiary, AdVita Lifescience GmbH, the company has been granted Orphan Drug Designation by the US FDA for RLF-100, an inhaled formulation in development for the treatment of sarcoidosis.
    [Relief Therapeutics, AG.]

    Press Release

    Glenmark Inks Agreement with Canadian Biotech SaNOtize to Commercialize Nitric Oxide Nasal Spray for COVID-19 Treatment in India and Other Asian Markets

    Glenmark Pharmaceuticals, Inc. and SaNOtize Research & Development Corp. announced an exclusive long term strategic partnership to manufacture, market and distribute its breakthrough Nitric Oxide Nasal Spray for COVID-19 treatment in India and other Asian markets including Singapore, Malaysia, Hong Kong, Taiwan, Nepal, Brunei, Cambodia, Laos, Myanmar, Sri Lanka, Timor-Leste and Vietnam.
    [Glenmark Pharmaceuticals, Inc.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Lung Cancer

    University Hospital of Cologne – Cologne, Germany

    Research Associate – Pancreatic, Colon and Lung Cancers.

    Westwood Bioscience, Inc. – Los Angeles, California, United States

    Research Assistant II – Lung Cancers

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Research Fellow – Viral and Bacterial Lung Infections

    Johns Hopkins University – Baltimore, Maryland, United States

    Postdoctoral Position – Lung Immunology

    Stanford School of Medicine – Palo Alto, California, United States

    > See All Jobs

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