Pulmonary Cell News Volume 10.30 | Aug 12 2021

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    2021-08-12 | PULCN 10.30


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.30 – 12 August, 2021
    TOP STORY

    Integrative Oncogene-Dependency Mapping Identifies RIT1 Vulnerabilities and Synergies in Lung Cancer

    Scientists investigate the oncogene-specific dependencies conferred by the lung cancer oncogene, RIT1. Genome-wide CRISPR screening in KRAS, EGFR, and RIT1-mutant isogenic lung cancer cells identifies shared and unique vulnerabilities of each oncogene.
    [Nature Communications]

    Full Article

    An informative, visually-compelling wallchart detailing the organization and biology of the respiratory system. Request your copy.
    PUBLICATIONSRanked by the impact factor of the journal

    YAP Regulates Alveolar Epithelial Cell Differentiation and AGER via NFIB/KLF5/NKX2-1

    Postnatal YAP activation increased epithelial cell proliferation, increased alveolar type-1 cell numbers, and caused indeterminate differentiation of subsets of alveolar cells expressing atypical genes normally restricted to airway epithelial cells.
    [iScience]

    AbstractGraphical Abstract

    Disease Modeling Following Organoid-Based Expansion of Airway Epithelial Cells

    Airway epithelial cells were obtained from tracheal aspirates (TA) from preterm newborns, and from bronchoalveolar lavage (BAL) or bronchial tissue (BT) from adults. TA and BAL cells were 3D-expanded, whereas cells from BT were expanded in 3D and 2D.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    Loss of Smad4 Promotes Aggressive Lung Cancer Metastasis by De-Repression of PAK3 via miRNA Regulation

    Molecularly, PAK3 was identified as a downstream effector of Smad4, mediating metastatic signal transduction via the PAK3-JNK-Jun pathway. Upregulation of PAK3 by Smad4 LOF in SPK mice was achieved by attenuating Smad4-dependent transcription of miR-495 and miR-543.
    [Nature Communications]

    Full Article

    USP12 Downregulation Orchestrates a Protumorigenic Microenvironment and Enhances Lung Tumor Resistance to PD-1 Blockade

    Scientists showed that the deubiquitinase USP12 was commonly downregulated in the KrasG12D-driven mouse lung tumor and human NSCLC owing to the activation of AKT-mTOR signaling.
    [Nature Communications]

    Full Article

    Comparative Transcriptome Analyses Reveal Genes Associated with SARS-CoV-2 Infection of Human Lung Epithelial Cells

    Researchers obtained high-throughput gene expression data associated with human lung epithelial cells infected with respiratory viruses such as SARS-CoV-2, SARS, H1N1, avian influenza, rhinovirus and Dhori, then performed comparative transcriptome analysis to identify SARS-CoV-2 exclusive genes.
    [Scientific Reports]

    Full Article

    Knockdown of lncRNA HIF1A-AS2 Increases Drug Sensitivity of SCLC Cells in Association with Autophagy

    Scientists determined the effect of lncRNA HIF1A-AS2 on autophagy-associated drug resistance in SCLC. The expression of HIF1A-AS2 was silenced by siRNA in doxorubicin-sensitive H69 and doxorubicin-resistant H69AR cells.
    [Medical Oncology]

    Abstract

    Identification of Prognostic Markers by Weighted Gene Co-Expression Network Analysis in Non-Small Cell Lung Cancer

    All hub genes were overexpressed in tumor tissue, and high expression of AURKB, CDC20, TPX2, and KIF2C correlated with the poor prognosis of non-small cell lung cancer patients. In vitro experiments confirmed that CDC20 knockdown inhibited cell proliferation and growth.
    [Bioengineered]

    Full Article

    Preparation and Characterization of Palladium Derivate-Loaded Micelle Formulation In Vitro as an Innovative Therapy Option against Non-Small Cell Lung Cancer Cells

    A549 and H1299 non-small lung cancer cell types were used for cytotoxicity using SRB and ATP assays. Fluorescent staining and M30 antigen assay were carried out for cell death evaluation.
    [Chemistry & Biodiversity]

    Abstract

    Learn about optimization of in vitro lung models in this webinar by Dr. Rachael Rayner
    REVIEWS

    Toward Personalized Treatment Approaches for Non-Small Cell Lung Cancer

    Scientists discuss some of the recent breakthrough therapies developed for NSCLC, focusing on immunotherapies and targeted therapies.
    [Nature Medicine]

    Abstract

    Coregulation of Pathways in Lung Cancer Patients with EGFR Mutation: Therapeutic Opportunities

    The authors highlight regulatory mechanisms and signaling pathways that cause therapy-induced resistance to epidermal growth factor receptor tyrosine kinase inhibitors.
    [British Journal of Cancer]

    Full Article

    INDUSTRY AND POLICY NEWS

    aTyr Pharma Announces Expansion of Research Collaboration with The Ohio State University

    aTyr Pharma, Inc. announced that the company has expanded its research collaboration with The Ohio State University to deepen the understanding of the immune mechanisms of sarcoid granuloma formation and identify potential biomarkers of efficacy for the company’s lead therapeutic candidate, ATYR1923, which is currently in clinical development for the treatment of pulmonary sarcoidosis.
    [aTyr Pharma, Inc.]

    Press Release

    FEATURED EVENT

    2nd Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference

    February 14 – 17, 2022
    Puerto Vallarta, Mexico

    > See All Events

    JOB OPPORTUNITIES

    Staff Researcher – Immune Responses after Heart and Lung Transplantation

    Washington University School of Medicine – St. Louis, Missouri, United States

    Research Associate – Pancreatic, Colon and Lung Cancers

    Westwood Bioscience, Inc. – Los Angeles, California, United States

    Research Assistant II – Lung Cancers

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Research Fellow – Viral and Bacterial Lung Infections

    Johns Hopkins University – Baltimore, Maryland, United States

    Postdoctoral Position – Lung Immunology

    Stanford School of Medicine – Palo Alto, California, United States

    > See All Jobs

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