Pulmonary Cell News Volume 10.31 | Aug 19 2021

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    2021-08-19 | PULCN 10.31


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.31 – 19 August, 2021
    TOP STORY

    LL-37 and HMGB1 Induce Alveolar Damage and Reduce Lung Tissue Regeneration via RAGE

    The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Metformin Attenuates Silica-Induced Pulmonary Fibrosis via AMPK Signaling

    Silicon dioxide-stimulated lung epithelial cells/macrophages and transforming growth factor-beta 1-induced differentiated lung fibroblasts were used for in vitro models.
    [Journal of Translational Medicine]

    Full Article

    Soft Robotic Constrictor for In Vitro Modeling of Dynamic Tissue Compression

    Researchers demonstrated cyclic compression of primary human endothelial cells, fibroblasts, and smooth muscle cells to show physiological changes in their morphology due to applied forces.
    [Scientific Reports]

    Full Article

    Vitamin D Suppresses Bleomycin-Induced Pulmonary Fibrosis by Targeting the Local Renin–Angiotensin System in the Lung

    The authors demonstrated that in lung fibroblast cultures, TGF-β and angiotensin II synergistically induced TGF-β, AT1R, α-SMA, collagen type I and fibronectin, whereas 1,25-dihydroxyvitamin D markedly suppressed the induction of these fibrotic markers.
    [Scientific Reports]

    Full Article

    SFPQ Rescues F508del-CFTR Expression and Function in Cystic Fibrosis Bronchial Epithelial Cells

    Investigators investigated the role of splicing factor proline/glutamine-rich (SFPQ) in the regulation of the expression and function of F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in cystic fibrosis lung epithelial cells.
    [Scientific Reports]

    Full Article

    Signaling Pathway Perturbation Analysis for Assessment of Biological Impact of Cigarette Smoke on Lung Cells

    Investigators reported the development of an algorithm based on quantitative assessment of transcriptomic profiles and signaling pathway perturbation analysis of human bronchial epithelial cells exposed to the toxic components present in cigarette smoke.
    [Scientific Reports]

    Full Article

    Anti-Inflammatory Actions of Aspirin-Triggered Resolvin D1 (AT-RvD1) in Bronchial Epithelial Cells Infected with Cryptococcus neoformans

    The interaction of Cryptococcus neoformans with airway epithelial cells is crucial for the establishment of cryptococcosis. Scientists evaluated the effects of AT-RvD1 on human bronchial epithelial cells stimulated with C. neoformans.
    [inflammopharmacology]

    Abstract

    Clinical, Genetic and Pharmacological Data Support Targeting the MEK5/ERK5 Module in Lung Cancer

    Using genetic as well as pharmacological tools, researchers showed that targeting the MEK5/ERK5 route was therapeutically effective in lung cancer.
    [npj Precision Oncology]

    Full Article

    FCH Domain Only 1 (FCHo1), a Potential New Biomarker for Lung Cancer

    Scientists demonstrated that F-BAR and mu homology domains existed separately in human lung tissues and that one truncated form was not detected in patients with lung cancer.
    [Cancer Gene Therapy]

    Abstract

    Five tips for returning to the lab after time off
    REVIEWS

    Respiratory Epithelial Cell Responses to SARS-CoV-2 in COVID-19

    COVID-19 has different clinical stages, and effective therapy depends on the location and extent of the infection. Scientists provide a background for understanding the progression of the disease throughout the pulmonary epithelium and discuss therapeutic options.
    [Thorax]

    Full Article

    Advances and Highlights in Asthma in 2021

    Recently published articles and clinical trials are summarized and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.
    [Allergy]

    Abstract

    INDUSTRY AND POLICY NEWS

    AmoyDx® Pan Lung Cancer PCR Panel Receives MHLW Approval as Companion Diagnostic for TEPMETKO® (Tepotinib)

    Riken Genesis Co., Ltd., Amoy Diagnostics Co., Ltd., and Precision Medicine Asia Co., Ltd. announced that the Ministry of Health, Labour and Welfare has approved the AmoyDx® Pan Lung Cancer PCR Panel as a companion diagnostic for TEPMETKO® a Merck KGaA, Darmstadt, Germany product that received approval by the Japanese MHLW in March 2020.
    [Riken Genesis Co., Ltd. (GlobeNewsWire, Inc.)]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Assistant/Associate/Full Professor Tenure-Track – Aging and Inflammation

    Medical College of Georgia, Augusta University – Augusta, Georgia, United States

    Staff Researcher – Immune Responses after Heart and Lung Transplantation

    Washington University School of Medicine – St. Louis, Missouri, United States

    Research Associate – Pancreatic, Colon and Lung Cancers

    Westwood Bioscience, Inc. – Los Angeles, California, United States

    Research Assistant II – Lung Cancers

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Research Fellow – Viral and Bacterial Lung Infections

    Johns Hopkins University – Baltimore, Maryland, United States

    > See All Jobs

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