 | | Vol. 10.32 – 26 August, 2021 |
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| The Jurkat T cells and non-small cell lung cancer cells co-culture model was used to assess the effect of apatinib on T cells activation. Subcutaneous tumor formation models were established to evaluate the effects of apatinib in vivo.
[Journal of Experimental & Clinical Cancer Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that ethyl ferulate significantly alleviated lipopolysaccharide-induced pathological damage and neutrophil infiltration and inhibited the gene expression of proinflammatory cytokines in murine lung tissues.
[Acta Pharmacologica Sinica] |
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| Alveolar macrophages were exposed to crystalline silica (CS) to develop an in vitro model, and mice were treated with CS to establish an in vivo model.
[Journal of Cellular and Molecular Medicine] |
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| By manipulating ROCK pathway, scientists demonstrated that stretch-induced Yap/Taz activation promoted alveolar differentiation towards alveolar epithelial type 1 phenotype via ROCK activity.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| In vitro Axl inhibition by R428 and Axl knock-down inhibited growth factor-driven proliferation and migration of non-pulmonary arterial hypertension and pulmonary arterial hypertension PASMCs.
[Communications Biology] |
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| Researchers described a unique, miniaturized 96-Transwell microplate system where human pluripotent stem cells-derived alveolar-like cells were cultured at an air–liquid interface.
[Scientific Reports] |
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| Cough-variant asthma (CVA) is a special type of asthma, solely manifesting with coughing. Investigators suggested that airway inflammation was associated with CVA pathogenesis.
[International Archives of Allergy and Immunology] |
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| The loss-of-function assays were used to investigate the effects of trafficking protein 3 (TMED3) on proliferation, apoptosis, cell cycle, and migration of lung squamous cell carcinoma cells.
[Cell Death & Disease] |
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| Researchers investigated the combined influence of cancer stem cells (CSCs), circular RNA, and immune checkpoint inhibitors in non-small cell lung cancer progression and therapy resistance and constructed lung CSCs.
[Cell Death & Disease] |
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| Scientists investigated the relationship between miR-144-3p and CEP55 expression. They evaluated the association between miR-144-3p and CEP55 expression and proliferation, invasion and apoptosis of non-small cell lung cancer cells.
[Acta Biochimica et Biophysica Sinica] |
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| The use of stem cells in recellularizing acellular lung scaffolds is reviewed, followed by case studies on the transplantation of bioengineered lungs.
[Regenerative Medicine] |
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| Blade Therapeutics, Inc. announced that the US FDA has activated the Company’s Investigational New Drug application to investigate cudetaxestat in IPF. Cudetaxestat is a non-competitive autotaxin inhibitor for fibrotic diseases.
[Blade Therapeutics, Inc.] |
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| September 30 – October 2, 2021
San Antonio, Texas, United States |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| Medical College of Georgia, Augusta University – Augusta, Georgia, United States |
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| Washington University School of Medicine – St. Louis, Missouri, United States |
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| Westwood Bioscience, Inc. – Los Angeles, California, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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