Pulmonary Cell News Volume 10.35 | Sep 16 2021

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    2021-09-16 | PULCN 10.35


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.35 – 16 September, 2021
    TOP STORY

    The Circadian Clock Component BMAL1 Regulates SARS-CoV-2 Entry and Replication in Lung Epithelial Cells

    Investigators demonstrated that silencing the circadian regulator Bmal1 or treating lung epithelial cells with the REV-ERB agonist SR9009 reduced ACE2 expression and inhibited SARS-CoV-2 entry and replication.
    [iScience]

    AbstractGraphical Abstract

    Resources for Your T Cell Therapy Research
    PUBLICATIONSRanked by the impact factor of the journal

    A cGAS-Dependent Response Links DNA Damage and Senescence in Alveolar Epithelial Cells: A Potential Drug Target in IPF

    Scientists investigated the role of the DNA-sensing GMP-AMP (cGAS) synthase in idiopathic pulmonary fibrosis (IPF), with a focus on alveolar epithelial cell senescence.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    Escherichia coli Infection Activates the Production of IFN-α and IFN-β via the JAK1/STAT1/2 Signaling Pathway in Lung Cells

    Researchers studied whether E. coli infections could regulate interferon production and the underlying mechanisms. Two lung cell lines, a human bronchial epithelial cell line transformed with Ad12-SV40 2B and a human fetal lung fibroblast cell line, were used.
    [Amino Acids]

    Full Article

    Air-Liquid Interphase Culture Confers SARS-CoV-2 Susceptibility to A549 Alveolar Epithelial Cells

    A549 cells in air-liquid interface culture yielded a layer of mucus on their apical surface, exhibited decreased expression levels of the proliferation marker KI-67 and intriguingly became susceptible to SARS-CoV-2 infection.
    [Biochemical and Biophysical Research Communications]

    Full Article

    Engineered Exosomes Loaded with miR-449a Selectively Inhibit the Growth of Homologous Non-Small Cell Lung Cancer

    As an efficient drug carrier, exosome has been widely used in the delivery of genetic drugs, chemotherapeutic drugs, and anti-inflammatory drugs. The authors demonstrated that miR-449a Exo effectively inhibited the proliferation of A549 cells and promoted their apoptosis.
    [Cancer Cell International]

    Full Article

    The Petroleum Ether Extract of Brassica rapa L. Induces Apoptosis of Lung Adenocarcinoma Cells via the Mitochondria-Dependent Pathway

    The effects and pharmacological mechanisms of BRPS on the treatment of lung cancer were investigated both in vitro and in vivo.
    [Food & Function]

    Full Article

    KCa Channel Blockers Increase Effectiveness of the EGF Receptor TK Inhibitor Erlotinib in Non-Small Cell Lung Cancer Cells (A549)

    Scientists identified three out of four datasets comparing erlotinib-sensitive and -resistant non-small cell lung cancer (NSCLC) cells which revealed an altered expression of KCa3.1 mRNA in erlotinib-resistant NSCLC cells.
    [Scientific Reports]

    Full Article

    Concomitant and Decoupled Effects of Cigarette Smoke and SCAL1 Upregulation on Oncogenic Phenotypes and ROS Detoxification in Lung Adenocarcinoma Cells

    A novel long noncoding RNA (lncRNA) called smoke and cancer-associated lncRNA 1 was recently found upregulated in smoke-exposed adenocarcinomic alveolar epithelial cells.
    [Scientific Reports]

    Full Article

    Identification of circ_0058357 as a Regulator in Non-Small Cell Lung Cancer Cells Resistant to Cisplatin by miR-361-3p/ABCC1 Axis

    Researchers identified the precise role of circular RNA circ_0058357 in the functional properties of DDP-resistant non-small cell lung cancer cells.
    [Thoracic Cancer]

    Full Article


    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    REVIEWS

    Tumor-Associated Exosomes Promote Lung Cancer Metastasis through Multiple Mechanisms

    Lung cancer is a major malignant tumor that seriously threatens human health. The study of the underlying mechanisms of exosomes in tumor genesis and development may provide new ideas for early and effective diagnosis and treatment of lung cancer metastasis.
    [Molecular Cancer]

    Full Article

    INDUSTRY AND POLICY NEWS

    AB Science Announced Today That It Has Received Authorization to Resume Patient Enrollment in the Phase II Masitinib Study of COVID-19 (AB20001)

    AB Science announced that it has received authorization from the Russian Health Ministry to resume patient enrollment in the Phase II masitinib study of COVID-19.
    [AB Science (GlobeNewsWire, Inc.)]

    Press Release

    FEATURED EVENT

    TEDD Annual Meeting: Cross-Industrial Applications of Organotypic Models

    October 14, 2021
    Wädenswil, Switzerland

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Lung Immunology

    Karolinska Institutet – Stockholm, Sweden

    PhD Studentship – Lung Metastatic Niche

    CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom

    Postdoctoral Scholar – Immunology of Lungs

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Assistant/Associate/Full Professor Tenure-Track – Aging and Inflammation

    Medical College of Georgia, Augusta University – Augusta, Georgia, United States

    Staff Researcher – Immune Responses after Heart and Lung Transplantation

    Washington University School of Medicine – St. Louis, Missouri, United States

    > See All Jobs

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