 | | Vol. 10.36 – 23 September, 2021 |
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| Researchers reported that autophagy was upregulated in lung cancer-associated cancer-associated fibroblasts (CAFs) compared to normal fibroblasts, and autophagy was responsible for the promoting effect of CAFs on non-small cell lung cancer cell migration and invasion.
[Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors investigated the role of miR-30a in the pulmonary artery smooth muscle cells remodeling of pulmonary arterial hypertension.
[Molecular Therapy-Nucleic Acids] |
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| Scientists tested whether sphingosine had any adverse effects in the respiratory tract when applied into isolated ventilated and perfused lungs. A four hour ex vivo lung perfusion run using minipig lungs was performed.
[Scientific Reports] |
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| Researchers explored the relationship between PAX3-FOXO1 and B7-H3 and the biological roles of B7-H3 in alveolar rhabdomyosarcoma. Quantitative real time PCR and flow cytometry revealed that PAX3-FOXO1 knockdown downregulated B7-H3 expression in all the selected cell lines, suggesting that PAX3-FOXO1 positively regulated B7-H3 expression.
[Scientific Reports] |
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| Scientists defined a new signaling pathway that regulated the transcription and expression of PD-L1 upon TGF-β treatment, which might have a significant impact on research into the application of immunotherapy in treating lung cancer.
[Experimental and Molecular Medicine] |
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| The authors found that conditioned medium harvested from WI-38 lung fibroblasts and H1299 lung adenocarcinoma cells exposed to 0.1Gy to 1Gy could enhance the migration and invasion of unirradiated H1299 cells in both 2D and 3D culturing circumstances.
[Aging-Us] |
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| Scientists explored the mechanism of lncRNA urothelial carcinoma-associated 1 (UCA1) promoting cisplatin resistance in lung adenocarcinoma (LUAD). The UCA1 expression level in LUAD cell lines was detected by reverse transcription‑quantitative polymerase chain reaction.
[Cancer Cell International] |
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| Researchers recently investigated the antitumour effect of digoxin, a well-established drug for treating heart failure, against nonsmall cell lung cancer A549 and H1299 cells.
[Bioscience Reports] |
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| The aim of the current investigation was to develop Poly (D, L-lactide-co-glycolide) nanoparticles (NPs) to sustain the brigatinib release for prolong time period and to examine the antitumor effect of the optimized NPs.
[Drug Development and industrial Pharmacy] |
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| Scientists discuss responses of the epithelium that promote airway immunopathology, with a focus on miRNAs that contribute to the breakdown of essential epithelial functions.
[Immunological Reviews] |
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| The authors provide a comprehensive review of published articles on autophagy in the context of lung cancer to have a complete view of the role of autophagy in lung cancer and its possible treatments.
[Cell Biology International] |
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| BetterLife Pharma, Inc. announced that its wholly owned subsidiary, Altum Pharmaceuticals Inc., and Pontificia Universidad Católica de Chile have enrolled the first patient in the Phase I portion of the Phase I-II randomized placebo controlled in COVID-19 patients.
[BetterLife Pharma Inc. (BioSpace)] |
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| October 27 – 29, 2021
Virtual |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| Karolinska Institutet – Stockholm, Sweden |
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| CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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| The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| Medical College of Georgia, Augusta University – Augusta, Georgia, United States |
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