Pulmonary Cell News Volume 10.37 | Oct 07 2021

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    2021-07-10 | PULCN 10.37


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.37 – 7 October, 2021
    TOP STORY

    Hamster Organotypic Modeling of SARS-CoV-2 Lung and Brainstem Infection

    Investigators developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offered a unique opportunity to study the early steps of viral infection and screening antivirals.
    [Nature Communications]

    Full Article

    Scientific resources to support your organoids research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    Antigen Presentation by Lung Epithelial Cells Directs CD4+TRM Cell Function and Regulates Barrier Immunity

    Researchers reported that lung epithelial cells, including distinct surfactant protein C (SPC)lowMHChigh epithelial cells, functioned as anatomically-segregated and temporally-dynamic antigen presenting cells.
    [Nature Communications]

    Full Article

    Cis-Acting Lnc-Cxcl2 Restrains Neutrophil-Mediated Lung Inflammation by Inhibiting Epithelial Cell CXCL2 Expression in Virus Infection

    Scientists identified an inducible lncRNA in the Cxcl2 gene locus, lnc-Cxcl2, which could selectively inhibit Cxcl2 expression in mouse lung epithelial cells but not in macrophages.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Culture with Apically Applied Healthy or Disease Sputum Alters the Airway Surface Liquid Proteome and Ion Transport across Human Bronchial Epithelial Cells.

    Researchers investigated how culture of normal human bronchial epithelial cells with apically applied secretions from healthy or disease lungs affected epithelial function with a view to providing better in vitro models of the in vivo environment.
    [American Journal of Physiology-Cell Physiology]

    Abstract

    Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo

    As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.
    [Evidence-Based Complementary and Alternative Medicine]

    Abstract

    B.1.617.2 Enters and Fuses Lung Cells with Increased Efficiency and Evades Antibodies Induced by Infection and Vaccination

    Investigators showed increased Calu-3 lung cell entry and enhanced cell-to-cell fusion of B.1.617.2, which might contribute to augmented transmissibility and pathogenicity of this variant.
    [Thoracic Cancer]

    Full ArticleGraphical Abstract

    Contribution of p53 in Sensitivity to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

    Researchers investigated the effects of p53 in primary sensitivity and acquired resistance to EGFR-TKIs in NSCLC cells.
    [Scientific Reports]

    Full Article

    Heterogeneous Distribution of PD-L1 Expression in the IASLC/ATS/ERS Classification of Lung Adenocarcinoma

    94 lung adenocarcinoma cases were reviewed in the Third Affiliated Hospital of Soochow University from January to December 2019. PD-L1 (DAKO 22C3) was used to test the PD-L1 expression in lung cancer tissue.
    [International Journal of Clinical Oncology]

    Abstract

    Comparative Microsomal Proteomics of a Model Lung Cancer Cell Line NCI-H23 Reveals Distinct Differences between Molecular Profiles of 3D and 2D Cultured Cells

    To ascertain phenotypical differences between these two distinct culture conditions, scientists carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.
    [Oncotarget]

    Full Article

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    REVIEWS

    Biomarkers of Response to Checkpoint Inhibitors beyond PD-L1 in Lung Cancer

    In this review, investigators address the state of PD-L1 testing in lung cancer, the role of tumor mutation burden as a predictive biomarker
    [Modern Pathology]

    Abstract

    Ferroptosis: A New Promising Target for Lung Cancer Therapy

    The authors summarize the characteristics of ferroptosis from its underlying basis and role in lung cancer and provide possible applications for it in lung cancer therapies.
    [Oxidative Medicine and Cellular Longevity]

    Full Article

    INDUSTRY AND POLICY NEWS

    Tenax Therapeutics Announces Clearance of the Investigational New Drug Application for Imatinib in Pulmonary Arterial Hypertension (PAH)

    Tenax Therapeutics, Inc. announced that the FDA has reviewed and cleared its Investigational New Drug application for a novel formulation of imatinib.
    [Tenax Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Annual London Stem Cell Network Symposium

    October 19, 2021
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Lung Cancer

    Massachusetts General Hospital – Boston, Massachusetts, United States

    Postdoctoral Research Fellow – Lung Injury

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    PhD Studentship – Lung Metastatic Niche

    CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom

    Postdoctoral Scholar – Immunology of Lungs

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Assistant/Associate/Full Professor Tenure-Track – Aging and Inflammation

    Medical College of Georgia, Augusta University – Augusta, Georgia, United States

    > See All Jobs

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