 | | Vol. 10.38 – 14 October, 2021 |
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| Scientists sequenced 155,098 transcriptomes from 21 human biospecimens, including 54,523 small cell lung cancer (SCLC) transcriptomes. They observed greater tumor diversity in SCLC than lung adenocarcinoma, driven by canonical, intermediate, and admixed subtypes.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Alveolar epithelial injury is one of the important pathological changes in idiopathic pulmonary interstitial fibrosis, but the regulatory mechanism remains unclear. The authors reported that alveolar epithelial type-II cells played important roles in the pathological process of pulmonary fibrosis.
[Cell Death & Disease] |
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| 3D airway epithelial tissues allowed to mimic exposure conditions in vitro, generated human-relevant toxicology data, and allowed to elucidate the mode of action of pollutants.
[Scientific Reports] |
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| Investigators exposed A549 alveolar epithelial cells at the air-liquid interface to unravel the genotoxic and oxidative stress-inducing potential of dibutyl phthalate with concentrations relevant at occupational settings.
[Environmental and Molecular Mutagenesis] |
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| Human bronchial epithelial cells BEAS-2B were stimulated with transforming growth factor-β1 at a concentration of 10 ng/mL, and CCCTC-binding factor (CTCF) overexpression plasmid and CTCF small interfering RNA were transfected into the cells.
[Pediatric Pulmonology] |
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| A patient-derived cell line obtained at the time of disease progression was used to identify NRAS gene amplification as an additional driver of drug resistance to combination EGFR/MET therapies.
[npj Precision Oncology] |
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| Scientists found that SETD1A positively regulated the Wnt/β-catenin pathway via interacting with and stabilizing β-catenin.
[Journal of Experimental & Clinical Cancer Research] |
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| Cell functional experiments revealed that lncRNA DARS-AS1 participated in enhancing lung adenocarcinoma proliferation, invasion, and migration by inhibiting miR-188-5p.
[Aging] |
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| Researchers unveiled disease-related protein networks by proteomic and bioinformatic assessment of laser-microdissected cancerous cells from seven lung squamous cell cancer compared with eight representative lung adenocarcinomas.
[Scientific Reports] |
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| In this review, the post-osimertinib treatment options for EGFR-mutated non-small cell lung cancer are analyzed, with an outlook to ongoing clinical trials.
[ESMO Open] |
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| Algernon Pharmaceuticals, Inc. announced that it has filed a pre-IND meeting request with the US FDA for its investigation of NP-120 for a planned Phase II study for the treatment of refractory chronic cough.
[Algernon Pharmaceuticals Inc.] |
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| November 1 – 3, 2021
Virtual |
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| Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| Massachusetts General Hospital – Boston, Massachusetts, United States |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| Medical College of Georgia, Augusta University – Augusta, Georgia, United States |
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