Pulmonary Cell News Volume 10.39 | Oct 21 2021

May 12, 2022

2021-10-21 | PULCN 10.39

Pulmonary Cell News by STEMCELL Technologies

Vol. 10.39 – 21 October, 2021

TOP STORY

An Airway Organoid-Based Screen Identifies a Role for the HIF1α-Glycolysis Axis in SARS-CoV-2 Infection

It is urgent to develop disease models to dissect mechanisms regulating SARS-CoV-2 infection. Researchers derived airway organoids from human pluripotent stem cells.
[Cell Reports]

Abstract Graphical Abstract

Watch this innovation showcase from ISSCR 2021 on applications of hPSC-derived lung models.

PUBLICATIONSRanked by the impact factor of the journal

Mice Lacking DYRK2 Exhibit Congenital Malformations with Lung Hypoplasia and Altered Foxf1 Expression Gradient

The authors showed that Dyrk2-deficient mice display congenital malformations in multiple organs. Transcriptome analysis revealed molecular pathology of Dyrk2-deficient mice, particularly with respect to Foxf1 reduction.
[Communications Biology]

Full Article

Gene Transfer of MRCKα Rescues Lipopolysaccharide-Induced Acute Lung Injury by Restoring Alveolar Capillary Barrier Function

Researchers investigated whether electroporation-mediated gene transfer of MRCKα to the lungs can attenuate LPS-induced acute lung injury in vivo.
[Scientific Reports]

Full Article

LUNG CANCER

Single-Cell RNA Sequencing for the Identification of Early-Stage Lung Cancer Biomarkers from Circulating Blood

Scientists performed single-cell RNA-sequencing analysis using Fluidigm C1 systems to characterize human lung cancer transcriptomes at single-cell resolution.
[NPJ Genomic Medicine]

Full Article

Single-Cell RNA Sequencing Reveals Distinct Tumor Microenvironmental Patterns in Lung Adenocarcinoma

To identify clinically relevant microenvironmental and cancer features, scientists applied single-cell RNA sequencing to ten human lung adenocarcinomas and ten normal control tissues.
[Oncogene]

Full Article

DARPP-32 Promotes ERBB3-Mediated Resistance to Molecular Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma

Scientists showed that dopamine and cyclic AMP-regulated phosphoprotein, Mr 32000 (DARPP-32) physically recruited ERBB3 to epidermal growth factor receptor (EGFR) to mediate switching from EGFR homodimers to EGFR:ERBB3 heterodimers to bypass EGFR tyrosine kinase inhibitor -mediated inhibition by potentiating ERBB3-dependent activation of oncogenic signaling.
[Oncogene]

Full Article

GOLPH3/CKAP4 Promotes Metastasis and Tumorigenicity by Enhancing the Secretion of Exosomal WNT3A in Non-Small-Cell Lung Cancer

The authors evaluated the function of golgi phosphoprotein 3 (GOLPH3) in NSCLC distal metastasis. GOLPH3 was expressed at high levels in samples from patients with NSCLC and was positively associated with clinicopathologic characteristics including clinical stage classification.
[Cell Death & Disease]

Full Article

TCTP Protein Degradation by Targeting mTORC1 and Signaling through S6K, Akt, and Plk1 Sensitizes Lung Cancer Cells to DNA-Damaging Drugs

Researchers investigated the role of mTORC1 in regulating translationally controlled tumor protein levels, thereby modulating chemosensitivity, in human lung cancer cells and an A549 lung cancer xenograft model.
[Scientific Reports]

Full Article

IRS1 Phosphorylation Underlies the Non-Stochastic Probability of Cancer Cells to Persist during EGFR Inhibition Therapy

Investigators found that differential serine/threonine phosphorylation of the insulin receptor substrate 1 (IRS1) protein determined the chance to persist of lung and of head and neck cancer cells under epidermal growth factor receptor inhibition, both in vitro and in vivo.
[Nature Cancer]

Abstract

Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.

REVIEWS

Lung Neuroendocrine Neoplasms: Recent Progress and Persistent Challenges

The author summarizes key recent developments relevant to the pathologic diagnosis of lung neuroendocrine neoplasms, including carcinoids, small cell lung carcinoma, and large cell neuroendocrine carcinoma.
[Modern Pathology]

Full Article

INDUSTRY AND POLICY NEWS

BeyondSpring Announces First Patient Treated in Phase II Study with Plinabulin Combined with Nivolumab + Ipilimumab in Patients in 3rd Line Recurrent Small-Cell Lung Cancer Patients Who Failed Checkpoint Inhibitors

BeyondSpring announced the first patient has been treated in an investigator-initiated, open-label Phase II study with lead asset plinabulin in combination with nivolumab + ipilimumab in patients with 3rd line recurrent small-cell lung cancer who failed checkpoint inhibitors and platinum-based chemotherapy.
[BeyondSpring, Inc.]

Press Release

FEATURED EVENT

An Airway Organoid-Based Screen Identifies a Role for the HIF1α-Glycolysis Axis in SARS-CoV-2 Infection

Mice Lacking DYRK2 Exhibit Congenital Malformations with Lung Hypoplasia and Altered Foxf1 Expression Gradient

Gene Transfer of MRCKα Rescues Lipopolysaccharide-Induced Acute Lung Injury by Restoring Alveolar Capillary Barrier Function

Single-Cell RNA Sequencing for the Identification of Early-Stage Lung Cancer Biomarkers from Circulating Blood

Single-Cell RNA Sequencing Reveals Distinct Tumor Microenvironmental Patterns in Lung Adenocarcinoma

DARPP-32 Promotes ERBB3-Mediated Resistance to Molecular Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma

GOLPH3/CKAP4 Promotes Metastasis and Tumorigenicity by Enhancing the Secretion of Exosomal WNT3A in Non-Small-Cell Lung Cancer

TCTP Protein Degradation by Targeting mTORC1 and Signaling through S6K, Akt, and Plk1 Sensitizes Lung Cancer Cells to DNA-Damaging Drugs

IRS1 Phosphorylation Underlies the Non-Stochastic Probability of Cancer Cells to Persist during EGFR Inhibition Therapy

Lung Neuroendocrine Neoplasms: Recent Progress and Persistent Challenges

BeyondSpring Announces First Patient Treated in Phase II Study with Plinabulin Combined with Nivolumab + Ipilimumab in Patients in 3rd Line Recurrent Small-Cell Lung Cancer Patients Who Failed Checkpoint Inhibitors

Applying Fundamental Principles of Lung Biology to Respiratory Health

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Postdoctoral Fellow – Lung Tumor

Advanced Research Assistant – Human Cell Atlas

Postdoctoral Fellowship – Lung Cancer

Postdoctoral Research Fellow – Lung Injury

Postdoctoral Scholar – Immunology of Lungs

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