 | | Vol. 10.40 – 28 October, 2021 |
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| The human lung A549 cells cultured on both stiff and soft polyurethane soft dendritic colloids membranes were found to be viable, capable of supporting the air–liquid interface cell culture, and maintained barrier integrity.
[ACS Applied Materials & interfaces] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Mouse and cell ALI models were constructed by lipopolysaccharide (LPS). NEAT1 knockdown efficiently attenuated LPS-induced ALI and reduced LPS-induced elevation of cytokines both in vitro and in vivo
[Journal of Biochemical and Molecular Toxicology] |
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| Researchers showed that ABL kinase allosteric inhibitors impaired mitochondrial integrity and decrease oxidative phosphorylation.
[Cell Reports] |
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| In human tissue samples and cell lines, xenografts, and genetic mouse models, NKX2-1 induced the ERK phosphatase DUSP6, which inactivated ERK.
[Oncogene] |
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| Ephexin1 was reported to be highly upregulated by oncogenic Ras, but the functional consequences of this remain poorly understood. The authors showed that Ephexin1 was highly expressed in colorectal cancer and lung cancer patient tissues.
[Cell Death & Disease] |
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| Researchers analyzed MIB1 expression levels in tumor samples and performed gain- and loss-of-function studies in cell lines to investigate potential roles of MIB1 in epithelial-to-mesenchymal transition, cell migration and cell survival.
[Molecular Cancer Research] |
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| Secondary cisplatin resistance majorly undermines the cisplatin efficacy leading to a worse prognosis. Scientists identified the role of the DLX6-AS1/miR-181a-5p/miR-382-5p/CELF1 axis in regulating cisplatin resistance of lung squamous cell carcinoma.
[Scientific Reports] |
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| Researchers elucidated the role of histone deacetylase 6 in regulating epithelial-mesenchymal transition-mediated metastasis via mRNA in NSCLC.
[Human Cell] |
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| Confluent A549 cancer and WI-38 normal cells were subjected to condition of hypoxia or normoxia, before exposure to high-LET protons microbeam. After six hours incubation, cells were harvested and assayed for colony formation, micronucleus formation, chromosome aberration and western blotting.
[Radiation Research] |
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| Investigators identified the morphological characteristics of the neuroendocrine phenotype in a human lung cancer cell line, induced by two cAMP elevating agents.
[Acta Histochemica] |
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| The authors review the relevant literature in this rapidly expanding field, including results from mouse models and human studies. In addition, they present a case for club cells as cells of origin of lung adenocarcinomas that arise in smokers.
[European Respiratory Review] |
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| TFF Pharmaceuticals, Inc. announced that it has received approval from Health Canada to begin a Phase I clinical trial of a dry powder formulation of niclosamide, an antiviral treatment with potential to address COVID-19 and other infectious diseases.
[TFF Pharmaceuticals, Inc.] |
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| November 8 – 10, 2021
Virtual |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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