Pulmonary Cell News Volume 10.41 | Nov 4 2021

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    2021-11-04 | PULCN 10.41


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.41 – 4 November, 2021
    TOP STORY

    Exosomal miR-338-3p Suppresses Non-Small Cell Lung Cancer Cells Metastasis by Inhibiting CHL1 through the MAPK Signaling Pathway

    Scientists evaluated the specific regulatory mechanisms of exosomal miR-338-3p/CHL1/MAPK signaling pathway axis in NSCLC. In vitro MTS and apoptotic assays were used to investigate the functions of CHL1 and exosomal miR-338-3p in NSCLC progression.
    [Cell Death & Disease]

    Full Article

    PneumaCult for primary airway epithelial cell culture at the air-liquid interface or as airway organoid.
    PUBLICATIONSRanked by the impact factor of the journal

    Nrf2 Attenuates Ferroptosis-Mediated IIR-ALI by Modulating TERT and SLC7A11

    Researchers found that telomerase reverse transcriptase (TERT) was significantly reduced in lung tissue of Nrf2−/− mice in the model of intestinal ischemia/reperfusion-induced acute lung injury (IIR-ALI).
    [Cell Death & Disease]

    Full Article

    Role of Lysocardiolipin Acyltransferase in Cigarette Smoke-Induced Lung Epithelial Cell Mitochondrial ROS, Mitochondrial Dynamics, and Apoptosis

    The authors investigated the role of lysocardiolipin acyltransferase expression and activity in mitochondrial oxidative stress, mitochondrial dynamics, and lung epithelial cell apoptosis.
    [Cell Biochemistry and Biophysics]

    Abstract

    A Novel Function of HRP-3 in Regulating Cell Cycle Progression via the HDAC–E2F1–Cyclin E Pathway in Lung Cancer

    The expression of endogenous HDGF-related protein 3 (HRP-3) in human lung cancer tissues and xenograft tumor models is indicative of its clinical relevance in lung cancer. Scientists demonstrated that HRP-3 directly bound to the E2F1 promoter on chromatin.
    [Cancer Science]

    Full Article

    Genetic Variants in Histone Modification Regions Are Associated with the Prognosis of Lung Adenocarcinoma

    Scientists investigated the association between genetic variants in the histone modification regions and the prognosis of lung adenocarcinoma after curative surgery.
    [Scientific Reports]

    Full Article

    CAMSAP3 Depletion Induces Lung Cancer Cell Senescence-Associated Phenotypes through Extracellular Signal-Regulated Kinase Inactivation

    The function of calmodulin-regulated spectrin-associated protein 3 (CAMSAP3) on the regulation of cellular senescence-associated phenotypes in human non-small cell lung cancer H460 cells were determined in CAMSAP3 deletion (H460/C3ko) cells.
    [Cancer Medicine]

    Full Article

    Construction of ceRNA Network to Identify the lncRNA and mRNA Related to Non-Small Cell Lung Cancer

    The NSCLC tissue and normal tissue samples were screened for genetic comparison in the TCGA database. The predicted lncRNA and mRNA in BEAS2B and A549 cells were detected.
    [PLoS One]

    Full Article

    lncRNA FOXD3-AS1 Promotes the Progression of Non-Small Cell Lung Cancer by Regulating the miR-135a-5p/CDK6 Axis

    The molecular mechanism underlying the role of forkhead box D3 antisense 1 (FOXD3‑AS1) in cancer development has not yet been fully elucidated. Researchers focused on non‑small cell lung cancer in order to gain insight into how FOXD3‑AS1 drives cancer progression.
    [Oncology Letters]

    Full Article

    Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 1 Increases Cellular Proliferation and Colony Formation Capacity in Lung Cancer via Activation of E2F Transcription Factor 1

    High procollagen‑lysine, 2‑oxoglutarate 5‑dioxygenase 1 (PLOD1) mRNA levels have been determined to be prognostically significant in numerous human malignancies. Researchers elucidated the pathological mechanism of procollagen‑lysine, 2‑oxoglutarate 5‑dioxygenase 1 in lung cancer.
    [Oncology Letters]

    Full Article

    LncRNA ASAP1-IT1 Enhances Cancer Cell Stemness via Regulating miR-509-3p/YAP1 Axis in NSCLC

    The authors investigated the role of ASAP1 Intronic Transcript 1 (ASAP1-IT1) in cancer cell stemness of non-small cell lung cancer.
    [Cancer Cell International]

    Full Article


    How is drug screening being revolutionized for cystic fibrosis? With organoids. Watch Sylvia Boj's webinar.
    REVIEWS

    NRG1 and NRG2 Fusions in Non-Small Cell Lung Cancer (NSCLC): Seven Years between Lights and Shadows

    Fusions in neuregulin 1 (NRG1) and neuregulin 2 (NRG2) genes are molecular features of non-small cell lung cancer. These rearrangements enhance ectopic expression of the NRG/ErbB receptor‐ligand and induce the triggering of downstream pathways.
    [Expert Opinion On Therapeutic Targets]

    Abstract

    INDUSTRY AND POLICY NEWS

    Achieve Life Sciences Announces Participation in November Investor Conferences

    Achieve Life Sciences, Inc. announced that the US FDA has completed its review and accepted an Investigational New Drug application to investigate cytisinicline as a cessation treatment for nicotine e-cigarette users.
    [Achieve Life Sciences, Inc. (GlobeNewswire, Inc.)]

    Press Release

    Centessa Pharmaceuticals Demonstrates Proof-of-Mechanism from First Three PiMZ Subjects Dosed in Part B of Phase I Study Evaluating ZF874

    Centessa Pharmaceuticals plc announced proof-of-mechanism data from the first three subjects dosed in the ongoing repeat dose Phase I Part B study of ZF874 in subjects carrying at least one Z-mutated alpha-1-antitrypsin allele.
    [Centessa Pharmaceuticals plc]

    Press Release

    FEATURED EVENT

    FSSCR French Society for Stem Cell Research

    November 9 – 10, 2021
    Montpellier, France

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Cardiovascular Sciences

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Faculty Position – Pediatric Asthma Research

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Lung Tumor

    MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Research Fellow – Lung Injury

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    Postdoctoral Fellowship – Lung Cancer

    Massachusetts General Hospital – Boston, Massachusetts, United States

    > See All Jobs

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