Pulmonary Cell News Volume 10.42 | Nov 18 2021

    By
    Justin.choi
    -
    0
    36






    2021-11-18 | PULCN 10.42


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.42 – 18 November, 2021
    TOP STORY

    Evolutionary Metabolic Landscape from Preneoplasia to Invasive Lung Adenocarcinoma

    Researchers performed large-scale targeted metabolomics on resected lesions and plasma obtained from invasive lung adenocarcinoma and its precursors, and deciphered the metabolic trajectories from atypical adenomatous hyperplasia to adenocarcinoma in situ.
    [Nature Communications]

    Full Article

    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    PUBLICATIONSRanked by the impact factor of the journal

    The Role of Macrophage–Fibroblast Interaction in Lipopolysaccharide-Induced Pulmonary Fibrosis: An Acceleration in Lung Fibroblast Aerobic Glycolysis

    The authors demonstrated that lipopolysaccharide promoted c-Jun N-terminal kinase signaling pathway activation and endogenous tumor necrosis factor-α secretion in pulmonary macrophages.
    [Laboratory Investigation]

    Abstract

    Toxicity of Stainless and Mild Steel Particles Generated from Gas–Metal Arc Welding in Primary Human Small Airway Epithelial Cells

    Scientists evaluated the toxicity of stainless and mild steel particles generated via gas–metal arc welding using primary human small airway epithelial cells and ToxTracker reporter murine stem cells, which tracked activation of six cancer-related pathways.
    [Scientific Reports]

    Full Article

    Common Cardiac Medications Potently Inhibit ACE2 Binding to the SARS-CoV-2 Spike, and Block Virus Penetration and Infectivity in Human Lung Cells

    Researchers found that ouabain, digitoxin, and digoxin blocked penetration by SARS-CoV-2 spike-pseudotyped virus into human lung cells, and infectivity by native SARS-CoV-2.
    [Scientific Reports]

    Full Article

    Deciphering Cell Lineage Specification of Human Lung Adenocarcinoma with Single-Cell RNA Sequencing

    Investigators performed single-cell RNA sequencing of 268,471 cells collected from 25 patients in four histologic stages of lung adenocarcinoma and compared them to normal cell types.
    [Nature Communications]

    Full Article

    TIAM1-RAC1 Promote Small-Cell Lung Cancer Cell Survival through Antagonizing Nur77-Induced BCL2 Conformational Change

    Researchers showed that the expression of TIAM1, an activator of the small GTPase RAC1, was associated with a neuroendocrine gene program.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Smoking-Associated Upregulation of CBX3 Suppresses ARHGAP24 Expression to Activate Rac1 Signaling and Promote Tumor Progression in Lung Adenocarcinoma

    Scientists explored the mechanisms regulating histone methylation in lung adenocarcinoma (LUAD) in response to smoking. They found that the histone H3K9 methylation reader CBX3 was upregulated in current smokers with LUAD, and that CBX3 overexpression promoted LUAD progression.
    [Oncogene]

    Full Article

    USP5 Facilitates Non-Small Cell Lung Cancer Progression through Stabilization of PD-L1

    The authors showed that ubiquitin specific peptidase 5 (USP5) directly interacted with PD-L1 and deubiquitinated PD-L1, therefore enhances PD-L1 protein stability.
    [Cell Death & Disease]

    Full Article

    Targeted Therapy for LIMD1-Deficient Non-Small Cell Lung Cancer Subtypes

    Scientists performed the first drug repurposing screen to identify compounds that conferred synthetic lethality with LIM domains containing 1 (LIMD1) loss in NSCLC cells.
    [Cell Death & Disease]

    Full Article

    Guide to everything you need to know about cell separation.
    REVIEWS

    Elastin in Healthy and Diseased Lung

    The authors consider elastin’s involvement in chronic respiratory disease and examine recent methods for imaging and modeling of the lung in the context of advances in lung tissue engineering for research and clinical application.
    [Current Opinion in Biotechnology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Northwestern Medicine Investigators Receive $14 Million Grant to Study Viral Pneumonia

    An interdisciplinary team of Northwestern Medicine investigators led by Karen Ridge, PhD, has been awarded a $14 million grant from the National Institute of Health’s National Heart, Lung, and Blood Institute to investigate the mechanisms that promote lung tissue repair in patients with severe viral pneumonia.
    [Northwestern Medicine]

    Press Release

    Primary Endpoint Met in COMET-TAIL Phase III Trial Evaluating Intramuscular Administration of Sotrovimab for Early Treatment of COVID-19

    GlaxoSmithKline plc and Vir Biotechnology, Inc. announced that the COMET-TAIL Phase III trial, which achieved its primary endpoint, demonstrating intramuscular administration of sotrovimab was non-inferior to intravenous administration for the early treatment of mild-to-moderate COVID-19 in high-risk, non-hospitalised adults and adolescents.
    [GlaxoSmithKline plc]

    Press Release

    FEATURED EVENT

    The Autoimmunity Conference

    December 5 – 9, 2021
    Jupiter, Florida, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Idiopathic Pulmonary Fibrosis

    NUI Galway – Galway, Ireland

    Postdoctoral Fellowship – Cardiovascular Sciences

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Faculty Position – Pediatric Asthma Research

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Lung Tumor

    MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Research Fellow – Lung Injury

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Pulmonary Cell News Twitter