Pulmonary Cell News Volume 10.47 | Nov 25 2021

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    2021-11-25 | PULCN 10.49


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.49 – 25 November, 2021
    TOP STORY

    The CLIP1–LTK Fusion Is an Oncogenic Driver in Non-Small Cell Lung Cancer

    Researchers identified a novel fusion transcript of CLIP1 and LTK using whole-transcriptome sequencing in a multi-institutional genome screening platform
    [Nature]

    Abstract

    Watch this webinar to learn the advantages of using primary human nasal epithelial cells to study Cystic Fibrosis.
    PUBLICATIONSRanked by the impact factor of the journal

    ACE2-Like Carboxypeptidase B38-CAP Protects from SARS-CoV-2-Induced Lung Injury

    Scientists showed that B38-CAP, an angiotensin-converting enzyme 2 (ACE2)-like enzyme, was protective against SARS-CoV-2-induced lung injury.
    [Nature Communications]

    Full Article

    Vitamin E Relieves Chronic Obstructive Pulmonary Disease by Inhibiting COX2-Mediated P-STAT3 Nuclear Translocation through the EGFR/MAPK Signaling Pathway

    Scientists explored the protective effect of vitamin E on chronic obstructive pulmonary disease and the underlying mechanisms.
    [Laboratory Investigation]

    Abstract

    Measurements of Spontaneous CFTR-Mediated Ion Transport without Acute Channel Activation in Airway Epithelial Cultures after Modulator Exposure

    To test if cystic fibrosis transmembrane conductance regulator (CFTR)-mediated ion transport could be measured in the absence of acute CFTR stimulation, primary airway epithelia were analyzed in an Ussing chamber with treatment of amiloride followed by CFTR(inh)-172 without acute activation of CFTR.
    [Scientific Reports]

    Full Article

    Soluble Guanylate Cyclase Signalling Mediates Etoposide Resistance in Progressing Small Cell Lung Cancer

    Scientists exploited six paired pre-treatment and post-chemotherapy circulating tumor cell patient-derived explant models from donors with extensive stage small cell lung cancer to investigate changes at disease progression after chemotherapy.
    [Nature Communications]

    Full Article

    TMEM116 Is Required for Lung Cancer Cell Motility and Metastasis through PDK1 Signaling Pathway

    The authors demonstrated that transmembrane protein (TMEM) 116 was highly expressed in non-small lung cancer cell tissues and cell lines.
    [Cell Death & Disease]

    Full Article

    Construction of circRNA-miRNA-mRNA Network and Identification of Novel Potential Biomarkers for Non-Small Cell Lung Cancer

    Circinteractome and StarBase databases were used to predict circRNA associated-miRNAs and mRNAs, respectively. Protein–protein interaction network of hub genes and ceRNA network were constructed by STRING and Cytoscape.
    [Cancer Cell International]

    Full Article

    Lipidomics Reveals That Sustained SREBP-1-Dependent Lipogenesis Is a Key Mediator of Gefitinib-Acquired Resistance in EGFR-Mutant Lung Cancer

    Researchers showed that gefitinib significantly induced downregulation of Sterol Regulator Element Binding (SREBP1) in therapy-sensitive cells.
    [Cell Death Discovery]

    Full Article

    TGF-β-Mediated Epithelial–Mesenchymal Transition and Tumor-Promoting Effects in CMT64 Cells Are Reflected in the Transcriptomic Signature of Human Lung Adenocarcinoma

    Scientists demonstrated for the first time that TGF-β could elicit epithelial–mesenchymal transition in a mouse lung adenocarcinoma cell line.
    [Scientific Reports]

    Full Article

    Ad-Apoptin Inhibits Glycolysis, Migration and Invasion in Lung Cancer Cells Targeting AMPK/mTOR Signaling Pathway

    Researchers investigated the effects of Ad-apoptin on glycolysis, migration and invasion of non-small cell lung cancer.
    [Experimental Cell Research]

    Full Article

    Prognosis Biomarker and Potential Therapeutic Target CRIP2 Associated with Radiosensitivity in NSCLC Cells

    NSCLC cell lines with acquired radioresistance to X-rays were obtained through fractionated irradiation. The differentially expressed proteins between the self-established radioresistant NSCLC cell line A549-R11 and control were measured by proteomic analysis.
    [Biochemical and Biophysical Research Communications]

    Abstract

    Explore Antibodies for Epithelial Cell Markers
    REVIEWS

    Research Progress on the Occurrence and Therapeutic Mechanism of Ferroptosis in NSCLC

    The research achievements in recent years on the regulating mechanism of ferroptosis and its effect on the occurrence and the therapy of lung cancer are reviewed.
    [Naunyn-Schmiedebergs Archives of Pharmacology]

    Abstract

    INDUSTRY AND POLICY NEWS

    HUTCHMED and AstraZeneca Initiate SACHI Phase III Trial of ORPATHYS® and TAGRISSO® Combination in Certain Lung Cancer Patients in China after Progression on EGFR Inhibitor Therapy

    HUTCHMED Limited and AstraZeneca PLC have initiated SACHI, a China Phase III study of ORPATHYS®, in combination with AstraZeneca’s third-generation, irreversible epidermal growth factor receptor TKI, TAGRISSO®.
    [HUTCHMED Ltd.]

    Press Release

    FEATURED EVENT

    Stem Cell Society Singapore Symposium 2021

    December 8 – 9, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Lung Disease

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Research Fellow – Idiopathic Pulmonary Fibrosis

    NUI Galway – Galway, Ireland

    Postdoctoral Fellowship – Cardiovascular Sciences

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Faculty Position – Pediatric Asthma Research

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Lung Tumor

    MD Anderson Cancer Center – Houston, Texas, United States

    > See All Jobs

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