Pulmonary Cell News Volume 10.48 | Dec 02 2021

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    2021-12-02 | PULCN 10.48


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.48 – 2 December, 2021
    TOP STORY

    Loss of DSTYK Activates Wnt/β-Catenin Signaling and Glycolysis in Lung Adenocarcinoma

    Researchers showed that the loss of dual serine/threonine tyrosine protein kinase (DSTYK) led to the activation of Wnt/β-catenin signaling and upregulation of its target gene, lactate dehydrogenase, and thus the elevation of lactate.
    [Cell Death & Disease]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Air Pollution-Regulated E-Cadherin Mediates Contact Inhibition of Proliferation via the Hippo Signaling Pathways in Emphysema

    Scientists investigated the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of proliferation in the lungs after air pollution exposure.
    [Chemico-Biological interactions]

    AbstractGraphical Abstract

    In Vitro Evidence of the Influence of Complexation of Pu and Am on Uptake by Human Lung Epithelial Cells Calu-3

    Investigators have evaluated in vitro the binding and uptake by bronchial epithelial cells Calu-3 of two transuranic actinides, plutonium (Pu) and americium (Am), as the first steps of translocation across the pulmonary barrier.
    [Toxicology in Vitro]

    AbstractGraphical Abstract

    Differential Placental CpG Methylation Is Associated with Chronic Lung Disease of Prematurity

    Epigenetic variation in placenta DNA methylation might be associated with differential risk of chronic lung disease, and these associations might be dependent upon sex.
    [Pediatric Research]

    Abstract

    Evaluation of Amentoflavone Metabolites on PARP-1 Inhibition and the Potentiation on Anti-Proliferative Effects of Carboplatin in A549 Cells

    Scientists reported bioactivity evaluation of amentoflavone metabolites in rat bile on PARP-1 and the potentiation of compound 8 on carboplatin in A549 cells in vitro.
    [Bioorganic & Medicinal Chemistry Letters]

    AbstractGraphical Abstract

    BLM Helicase Inhibition Synergizes with PARP Inhibition to Improve the Radiosensitivity of Olaparib Resistant Non-Small Cell Lung Cancer Cells by Inhibiting Homologous Recombination Repair

    Researchers investigated the radiosensitizing efficacy of the poly-ADP-ribose polymerase (PARP) inhibitor, olaparib, and the bloom syndrome protein (BLM) helicase inhibitor, ML216, in NSCLC cells.
    [Cancer Biology & Medicine]

    Abstract

    Downregulation of miR-29c Promotes Muscle Wasting by Modulating the Activity of Leukemia Inhibitory Factor in Lung Cancer Cachexia

    Investigators explored the mechanisms and correlation between miR-29c and muscle wasting in lung cancer cachexia.
    [Cancer Cell International]

    Full Article

    Analysis at the Single-Cell Level Indicates an Important Role of Heterogeneous Global DNA Methylation Status on the Progression of Lung Adenocarcinoma

    Scientists used publicly available single-cell RNAseq data to investigate the impact and diversity of global methylation status on lung adenocarcinoma.
    [Scientific Reports]

    Full Article

    CircRPPH1 Promotes Cell Proliferation, Migration and Invasion of Non-Small Cell Lung Cancer (NSCLC) via the PI3K/AKT and JAK2/STAT3 Signaling Axes

    Using ectopic plasmid incorporation and siRNA assays, investigators analyzed the circRPPH1-mediated regulation of cell proliferation, migration, and invasion in NSCLC cell lines, using CCK-8, colony forming, scratch wound, and transwell assays, respectively.
    [Journal of Biochemistry]

    Abstract

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    REVIEWS

    The Role of Immune Cells in Pulmonary Hypertension: Focusing on Macrophages

    The authors reviewed the molecular mechanisms and the role of immune cells and responses involved in pulmonary hypertension development.
    [Human Immunology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Sound Life Sciences Receives FDA 510(k) Clearance for Industry’s First Contactless Sonar-Based Respiratory Monitor for Smart Devices

    Sound Life Sciences, announced that it has received 510(k) clearance from the US FDA. The privately-held telehealth startup’s smartphone or smartspeaker app produces inaudible ultrasonic sonar pulses to detect reflections caused by nearby patient respiration.
    [Sound Life Sciences (BusinessWire, Inc.)]

    Press Release

    Blade Therapeutics Announces Positive Topline Data from Phase I Clinical Study of Cudetaxestat, a Non-Competitive Autotaxin Inhibitor in Clinical Development for Idiopathic Pulmonary Fibrosis

    Blade Therapeutics, Inc. announced positive topline data from a Phase I drug-drug interaction clinical study of cudetaxestat, an investigational non-competitive autotaxin inhibitor in clinical development for idiopathic pulmonary fibrosis.
    [Blade Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Cell Bio Virtual 2021

    December 1 – 10, 2021
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    JOB OPPORTUNITIES

    Associate/Full Professor of Medicine – Pulmonary

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    Postdoctoral Position – Lung Disease

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Fellowship – Cardiovascular Sciences

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Faculty Position – Pediatric Asthma Research

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Lung Tumor

    MD Anderson Cancer Center – Houston, Texas, United States

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