Pulmonary Cell News Volume 10.50 | Dec 16 2021

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    2021-12-16 | PULCN 10.50


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.50 – 16 December, 2021
    TOP STORY

    Distinct Roles of KLF4 in Mesenchymal Cell Subtypes during Lung Fibrogenesis

    Researchers indicated that KLF4 played opposing roles in platelet-derived growth factor receptor-β+ cells and α-smooth muscle actin+ cells and highlighted the importance of further studies of interactions between distinct mesenchymal cell types.
    [Nature Communications]

    Full Article

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    Nonmuscle Myosin Heavy Chain IIA Facilitates SARS-CoV-2 Infection in Human Pulmonary Cells

    The authors identified nonmuscle myosin heavy chain IIA as an important host factor for SARS-CoV-2 infection of human pulmonary cells by using APEX2 proximity-labeling techniques.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Impact of Reactive Iron in Coal Mine Dust on Oxidant Generation and Epithelial Lung Cell Viability

    Scientists revealed that reduced iron minerals were widely distributed within samples obtained from Australian coal mines with pyrite and siderite being particularly abundant. Compared with carbon and crystalline silica, the presence of these specific iron minerals were negatively correlated to the viability of both alveolar macrophages and human lung epithelial cells.
    [Science of the Total Environment]

    AbstractGraphical Abstract

    Enhanced Apoptosis as a Possible Mechanism to Self-Limit SARS-CoV-2 Replication in Porcine Primary Respiratory Epithelial Cells in Contrast to Human Cells

    Researchers investigated species-specific cell susceptibility, virus dose-dependent infectivity, and infection kinetics, using primary human and porcine respiratory epithelial cells.
    [Cell Death Discovery]

    Full Article

    FK228 Potentiates Topotecan Activity against Small Cell Lung Cancer Cells via Induction of SLFN11

    The authors investigated how schlafen family member 11 (SLFN11) expression regulated the sensitivity of small cell lung cancer to topotecan.
    [Acta Pharmacologica Sinica]

    Abstract

    A Small-Molecule Compound D6 Overcomes EGFR-T790M-Mediated Resistance in Non-Small Cell Lung Cancer

    Researchers presented a small-molecule compound D6 which selectively inhibited tumor cell growth and migration in NSCLC cells with EGFR-tyrosine kinase inhibitor-resistant T790M-EGFR-activated mutations.
    [Communications Biology]

    Full Article

    EGPI-1, a Novel eIF4E/eIF4G Interaction Inhibitor, Inhibits Lung Cancer Cell Growth and Angiogenesis through Ras/MNK/ERK/eIF4E Signaling Pathway

    Scientists synthesized a series of small molecule compounds with the potential to inhibit eIF4E. The compound EGPI-1 significantly inhibited the proliferation of a variety of lung cancer cells such as A549, NCI-H460, NCI-H1650 and 95D without inhibiting the proliferation of HUVEC cells.
    [Chemico-Biological interactions]

    Full ArticleGraphical Abstract

    CD48-Expressing Non-Small Cell Lung Cancer Cells Are Susceptible to Natural Killer Cell–Mediated Cytotoxicity

    Investigators showed that several NSCLC cell lines had differential sensitivity to natural killer cell–mediated cytotoxicity: NCI-H522 cells were highly sensitive, but A549, NCI-H23, NCI-H1915, and NCI-H1299 were resistant.
    [Archives of Pharmacal Research]

    Abstract

    Downregulation of KIF15 Inhibits the Tumorigenesis of Non-Small Cell Lung Cancer via Inactivating Raf/MEK/ERK Signaling

    Cell counting kit-8, flow cytometry and transwell assays were performed to determine the proliferation, apoptosis and invasion of NSCLC cells, respectively. In addition, Western blotting was used to detect the levels of phosphorylated (p-)c-Raf, p-ERK and p-MEK in NSCLC cells.
    [Histology and Histopathology]

    AbstractFull Article


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    REVIEWS

    Transient Receptor Potential Cation Channel Subfamily V (TRPV) and Its Importance in Asthma

    Transient receptor potential vanilloid 2 (TRPV2) may represent a novel biomarker for asthma in children; meanwhile, TRPV1 and TRPV4 seem to be essential contributors to the development and exacerbations of asthma.
    [European Journal of Pharmacology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Cullinan Oncology Announces Updated Phase I/IIa Data for CLN-081 in NSCLC EGFR Exon 20 Patients

    Cullinan Oncology, Inc. reported updated data from the Company’s ongoing Phase I/IIa trial of CLN-081 in NSCLC patients whose tumors harbor epidermal growth factor receptor exon 20 insertion mutations that have progressed on or after prior therapy.
    [Cullinan Oncology, Inc.]

    Press Release

    CareDx Enrolls First Patient in LungCare Registry Study to Measure Impact of Multimodality Assessment on Lung Transplant Patient Outcomes

    CareDx, Inc. announced the enrollment of the first patient in the multicenter, observational, prospective ALAMO registry to improve lung transplant patient care.
    [CareDx, Inc.]

    Press Release

    FEATURED EVENT

    AACR: Cancer Metastasis

    January 9 – 12, 2022
    Portland, Oregon, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scientist – Bioinformatics

    MRC London Institute of Medical Sciences – London, England, United Kingdom

    Postdoctoral Position – Molecular Biology

    National Institutes of Health – Bethesda, Maryland, United States

    Associate/Full Professor of Medicine – Pulmonary

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    Postdoctoral Position – Lung Disease

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Fellowship – Cardiovascular Sciences

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    > See All Jobs

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