Pulmonary Cell News Volume 11.00 | Jan 6 2021

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    2022-01-06 | PULCN 11.00


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.00 – 6 January, 2022
    TOP STORY

    Human Alveolar Type 2 Epithelium Transdifferentiates into Metaplastic KRT5+ Basal Cells

    Researchers demonstrated that human alveolar type 2 cells (hAEC2s), unlike murine AEC2s, transdifferentiated into basal cells in response to fibrotic signalling in the lung mesenchyme, in vitro and in vivo.
    [Nature Cell Biology]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    ITGB4 Deficiency Induces Mucus Hypersecretion by Upregulating MUC5AC in RSV-Infected Airway Epithelial Cells

    Researchers found that decreased expression of ITGB4 was negatively correlated with the level of MUC5AC in childhood airway epithelial cells following respiratory syncytial virus (RSV) infection.
    [International Journal of Biological Sciences]

    Full ArticleGraphical Abstract

    Metabolomic Dynamics of the Arsenic-Transformed Bronchial Epithelial Cells and the Derived Cancer Stem-Like Cells

    By applying untargeted global metabolomics approach, the authors showed that arsenic was highly capable of perturbing the intracellular metabolic programs of the human bronchial epithelial cells, some of which were prominent hallmarks of cancer cell metabolism.
    [International Journal of Biological Sciences]

    Full ArticleGraphical Abstract

    FGF21 Attenuates Pulmonary Arterial Hypertension via Downregulation of miR-130, Which Targets PPARγ

    Using miRNA sequencing and real-time PCR, researchers found that fibroblast growth factor 21 (FGF21) treatment inhibited miR-130 elevation in hypoxia-induced PAH in vitro and in vivo.
    [Journal of Cellular and Molecular Medicine]

    Abstract

    Calcitonin Gene-Related Peptide Attenuates Hyperoxia-Induced Oxidative Damage in Alveolar Epithelial Type II Cells through Regulating Viability and Transdifferentiation

    Scientists explored the effect of calcitonin gene-related peptide on AECII exposed to hyperoxia and its potential mechanisms.
    [Inflammation]

    Abstract

    Anti-PD-L1/TGF-βR Fusion Protein (SHR-1701) Overcomes Disrupted Lymphocyte Recovery-Induced Resistance to PD-1/PD-L1 Inhibitors in Lung Cancer

    Murine CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic mice. 
    [Cancer Communications]

    Abstract

    FBI-1 Inhibits Epithelial-to-Mesenchymal Transition, Migration, and Invasion in Lung Adenocarcinoma A549 Cells by Downregulating Transforming Growth Factor-β1 Signaling Pathway

    To investigate the function of factor binding inducer of short transcripts-1 (FBI-1) in epithelial-to-mesenchymal transition (EMT) in lung cancer, EMT was measured in FBI-1-deficient or FBI-1-overexpressing cells.
    [Journal of Cellular Biochemistry]

    Abstract

    Circ_0007385 Regulates Cell Proliferation, Apoptosis and Stemness via Targeting miR-493-3p/RAB22A Axis in Non-Small Cell Lung Cancer

    Expression levels of circ_0007385, microRNA-493-3p (miR-493-3p) and Ras-related protein Rab-22A (RAB22A) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) in NSCLC tissues and cells.
    [Thoracic Cancer]

    Full Article

    Myconoside Interacts with the Plasma Membranes and the Actin Cytoskeleton and Provokes Cytotoxicity in Human Lung Adenocarcinoma A549 Cells

    Scientists proposed a putative mechanism of action of myconoside on A549 cells plasma membrane lipids as well as on actin filaments in order to explain its cytotoxic effect at high myconoside concentration.
    [Journal of Bioenergetics and Biomembranes]

    Abstract

    CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-Small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44

    The authors investigated the role of circular RNA F-box and WD repeat domain containing 8 (circFBXW8) in NSCLC progression and the underlying mechanism.
    [Biochemical Genetics]

    Abstract

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    REVIEWS

    Chemotherapy plus Single/Double Immunotherapy in the Treatment of Non-Oncogene Addicted Advanced Non-Small Cell Lung Cancer: Where Do We Stand and Where Are We Going?

    Scientists assess and discuss the available data concerning chemo-immunotherapy combinations in the treatment of naïve advanced NSCLC, as well as presenting the most promising data involving combinations currently under investigation.
    [Expert Review of Anticancer Therapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    Aceragen Announces $3.5 Million Development Award from Cystic Fibrosis Foundation to Progress Novel Therapy for CF-Related Exacerbations

    Aceragen, Inc. announced that its wholly-owned subsidiary, Arrevus, Inc., has received an award from the Cystic Fibrosis Foundation for up to $3.5 million to support the clinical development of ACG-701, a proprietary formulation of sodium fusidate, as a treatment for cystic fibrosis-related pulmonary exacerbations.
    [Aceragen, Inc.]

    Press Release

    Cocrystal Pharma Receives FDA Guidance to Advance Clinical Development of Its COVID-19 Antiviral CDI-45205

    Cocrystal Pharma, Inc. announces receipt of guidance from the US FDA for the further development of CDI-45205, Cocrystal’s novel SARS-CoV-2 main protease inhibitor as a potential treatment for COVID-19 and its variants via intranasal/pulmonary delivery.
    [Cocrystal Pharma, Inc.]

    Full Article

    FEATURED EVENT

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    January 21 -23, 2022
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    JOB OPPORTUNITIES

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    Postdoctoral Associate – Molecular and Cellular Biology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Position – Molecular Biology

    National Institutes of Health – Bethesda, Maryland, United States

    Associate/Full Professor of Medicine – Pulmonary

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    Postdoctoral Position – Lung Disease

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

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