| Vol. 11.00 – 6 January, 2022 |
| |
|
|
| Researchers demonstrated that human alveolar type 2 cells (hAEC2s), unlike murine AEC2s, transdifferentiated into basal cells in response to fibrotic signalling in the lung mesenchyme, in vitro and in vivo. [Nature Cell Biology] |
| | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers found that decreased expression of ITGB4 was negatively correlated with the level of MUC5AC in childhood airway epithelial cells following respiratory syncytial virus (RSV) infection. [International Journal of Biological Sciences] |
|
|
|
| By applying untargeted global metabolomics approach, the authors showed that arsenic was highly capable of perturbing the intracellular metabolic programs of the human bronchial epithelial cells, some of which were prominent hallmarks of cancer cell metabolism. [International Journal of Biological Sciences] |
|
|
|
| Using miRNA sequencing and real-time PCR, researchers found that fibroblast growth factor 21 (FGF21) treatment inhibited miR-130 elevation in hypoxia-induced PAH in vitro and in vivo. [Journal of Cellular and Molecular Medicine] |
|
|
|
| Scientists explored the effect of calcitonin gene-related peptide on AECII exposed to hyperoxia and its potential mechanisms. [Inflammation] |
|
|
|
|
| Murine CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic mice. [Cancer Communications] |
|
|
|
| To investigate the function of factor binding inducer of short transcripts-1 (FBI-1) in epithelial-to-mesenchymal transition (EMT) in lung cancer, EMT was measured in FBI-1-deficient or FBI-1-overexpressing cells. [Journal of Cellular Biochemistry] |
|
|
|
| Expression levels of circ_0007385, microRNA-493-3p (miR-493-3p) and Ras-related protein Rab-22A (RAB22A) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) in NSCLC tissues and cells. [Thoracic Cancer] |
|
|
|
| Scientists proposed a putative mechanism of action of myconoside on A549 cells plasma membrane lipids as well as on actin filaments in order to explain its cytotoxic effect at high myconoside concentration. [Journal of Bioenergetics and Biomembranes] |
|
|
|
| The authors investigated the role of circular RNA F-box and WD repeat domain containing 8 (circFBXW8) in NSCLC progression and the underlying mechanism. [Biochemical Genetics] |
| |
|
|
|
| Scientists assess and discuss the available data concerning chemo-immunotherapy combinations in the treatment of naïve advanced NSCLC, as well as presenting the most promising data involving combinations currently under investigation. [Expert Review of Anticancer Therapy] |
|
|
|
|
| Aceragen, Inc. announced that its wholly-owned subsidiary, Arrevus, Inc., has received an award from the Cystic Fibrosis Foundation for up to $3.5 million to support the clinical development of ACG-701, a proprietary formulation of sodium fusidate, as a treatment for cystic fibrosis-related pulmonary exacerbations. [Aceragen, Inc.] |
|
|
|
| Cocrystal Pharma, Inc. announces receipt of guidance from the US FDA for the further development of CDI-45205, Cocrystal’s novel SARS-CoV-2 main protease inhibitor as a potential treatment for COVID-19 and its variants via intranasal/pulmonary delivery. [Cocrystal Pharma, Inc.] |
|
|
|
|
| January 21 -23, 2022 Austin, Texas, United States |
|
|
|
|
|
| Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States |
|
|
|
| Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| National Institutes of Health – Bethesda, Maryland, United States |
|
|
|
| Indiana University School of Medicine – Indianapolis, Indiana, United States |
|
|
|
| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
|
|
|
|