 | | Vol. 11.02 – 20 January, 2022 |
| |
|
|
| Researchers established a multi-omics atlas, integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing. They investigated their differences in genetic amplification, cellular compositions, and expression modules.
[Signal Transduction and Targeted Therapy] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists reported that absence of isthmin 1 (ISM1) in mice led to increase in alveolar macrophages number and functional heterogeneity, with enduring lung inflammation, progressive emphysema, and significant lung function decline, phenotypes similar to COPD.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Disruptor of telomeric silencing-1 like (DOT1L), H3K79me3, and the profibrotic proteins levels were upregulated in the pulmonary fibrosis models both in vivo and in vitro.
[Cell Death & Disease] |
|
|
|
| Selecting drug combinations for overcoming resistances, NSCLC patient-derived xenograft tumors were treated with a low dose combination of cabozantinib, afatinib, plerixafor and etoricoxib.
[Communications Biology] |
|
|
|
| Researchers presented a standardized primary alveolar cell culture method for establishing a human alveolar epithelium model that could recapitulate viral infection and cellular plasticity.
[Communications Biology] |
|
|
|
| By establishing a mouse model of radiation-induced lung injury and orthotopic lung tumor-bearing mouse model, investigators detected the role of Rac1 inhibition in the protection of radiation-induced lung injury and suppression of lung tumor.
[Cell Death Discovery] |
| |
|
|
| The authors explored the downstream mechanism of Jumonji domain containing protein 2C (JMJD2C) in NSCLC from the long non-coding RNA metastasis associated with lung adenocarcinoma transcript 1/microRNA-503-5p/septin 2 axis.
[Cell Death & Disease] |
|
|
|
| Silencing procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD3) promoted the cleavage of protein kinase C δ (PKCδ) in a caspase-dependent manner to generate a catalytically active fragment cleaved PKCδ, enhanced phosphorylation levels of CDK1, and LIMD1 but suppressed nuclear translocation of YAP1.
[Laboratory Investigation] |
|
|
|
| Secretion analysis revealed that cancer cells vary in their secretion level, with some cell lines having relatively low secretion rates.
[Scientific Reports] |
|
 |
|
|
|
| A severe pulmonary ventilation-perfusion mismatch usually triggers moderate to severe COVID-19 cases. Imaging can aid the physician in assessing severity of COVID-19.
[Molecular Imaging and Biology] |
|
|
|
|
| Amgen announced that LUMAKRAS® has been approved in Japan for the treatment of KRAS G12C-mutated positive, unresectable, advanced and/or recurrent NSCLC that has progressed after systemic anticancer therapy.
[Amgen, Inc.] |
|
|
|
|
| January 23 – 26, 2022
Breckenridge, Colorado, United States & Online |
|
|
|
|
|
| Albert Einstein College of Medicine – Bronx, New York, United States |
|
|
|
| Albert Einstein College of Medicine – Bronx, New York, United States |
|
|
|
| Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States |
|
|
|
| Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| National Institutes of Health – Bethesda, Maryland, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
